DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHRM3 and Octbeta2R

DIOPT Version :10

Sequence 1:NP_000731.1 Gene:CHRM3 / 1131 HGNCID:1952 Length:590 Species:Homo sapiens
Sequence 2:NP_001163596.2 Gene:Octbeta2R / 41549 FlyBaseID:FBgn0038063 Length:630 Species:Drosophila melanogaster


Alignment Length:620 Identity:143/620 - (23%)
Similarity:230/620 - (37%) Gaps:222/620 - (35%)


- Green bases have known domain annotations that are detailed below.


Human     3 LHNNSTTSPLFPNISSSWIHSPSDA-GLPPGT---VTH-------FG----SYNVSRA--AGNFS 50
            ||   ||:.|....|||..:|.:.. .||.||   .||       ||    ::|.|.|  :.:..
  Fly    76 LH---TTNALAATGSSSASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHH 137

Human    51 SPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADL 115
            ......|:....:.||  ||.||:..::.:..|.||:|||:|....::|:.:.|||::|||.||:
  Fly   138 HQQHNPDEDWLDNIVW--VFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADI 200

Human   116 IIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR 180
            ::.:::|....:..:..||......||||.::|...|.||:::|..||.|||::|.:||.|....
  Fly   201 MVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISM 265

Human   181 TTKRAGVMIGLAWVISFVLWAPAIL-FWQYFVGKRTVPPGECFIQFLSEPT----------ITFG 234
            |.:..|:|:...|:      :||:| |...|:|..|.|..:.|:  :..||          ....
  Fly   266 TKRVVGIMLLNTWI------SPALLSFLPIFIGWYTTPQHQQFV--IQNPTQCSFVVNKYYAVIS 322

Human   235 TAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQS 299
            ::| :|::|.|||...|..|::|..::.|:|                                 .
  Fly   323 SSI-SFWIPCTIMIFTYLAIFREANRQEKQL---------------------------------M 353

Human   300 MKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAI 364
            |:..|.....|       .|.:||.|                   :|..|.|       |:|..:
  Fly   354 MRHGNAMLMHR-------PSMQPSGE-------------------ALSGSGS-------SKTLTL 385

Human   365 YSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPI 429
            :.:           .....|:.|                                          
  Fly   386 HEV-----------EQEHTPTKD------------------------------------------ 397

Human   430 QLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLS 494
                                                       ..:.|.||     |.|||:||.
  Fly   398 -------------------------------------------KHLIKMKR-----EHKAARTLG 414

Human   495 AILLAFIITWTPYNIMVLVNTFCDSC-IPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKML 558
            .|:..||:.|.|:.:...::..|:.| :|....::.:|:.|.|||:||:.||..|:.||..|:..
  Fly   415 IIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNT 479

Human   559 LLCQ-CDKKK-----------RRKQQYQQRQSVIF 581
            |||. |:..|           |...:|.||...::
  Fly   480 LLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVY 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRM3NP_000731.1 7tmA_mAChR_M3 66..>270 CDD:320426 68/214 (32%)
TM helix 1 70..96 CDD:320426 10/25 (40%)
TM helix 2 103..130 CDD:320426 9/26 (35%)
TM helix 3 141..171 CDD:320426 14/29 (48%)
TM helix 4 183..206 CDD:320426 6/23 (26%)
TM helix 5 228..257 CDD:320426 10/38 (26%)
Basolateral sorting signal 275..281 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..357 5/33 (15%)
7tm_GPCRs <484..564 CDD:475119 30/81 (37%)
TM helix 6 490..512 CDD:320426 8/21 (38%)
TM helix 7 523..548 CDD:320426 9/24 (38%)
Octbeta2RNP_001163596.2 7tmA_DmOct-betaAR-like 155..476 CDD:320194 109/496 (22%)
TM helix 1 155..181 CDD:320194 10/25 (40%)
TM helix 2 188..214 CDD:320194 9/25 (36%)
TM helix 3 226..256 CDD:320194 14/29 (48%)
TM helix 4 268..291 CDD:320194 7/28 (25%)
TM helix 5 315..344 CDD:320194 8/29 (28%)
TM helix 6 404..434 CDD:320194 13/34 (38%)
TM helix 7 444..469 CDD:320194 9/24 (38%)

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