DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHRM3 and mAChR-B

DIOPT Version :10

Sequence 1:NP_000731.1 Gene:CHRM3 / 1131 HGNCID:1952 Length:590 Species:Homo sapiens
Sequence 2:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster


Alignment Length:925 Identity:191/925 - (20%)
Similarity:296/925 - (32%) Gaps:413/925 - (44%)


- Green bases have known domain annotations that are detailed below.


Human    41 NVSRAAGNFSSPDGTT------DDPLGG-----HTVWQVVFIAFLTGILALVTIIGNILVIVSFK 94
            |:..|..|.||..|:|      |..:.|     ..:||.:.||....|..::|:.|||||:::|.
  Fly    95 NLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTILIAICLAICIILTVGGNILVLLAFI 159

Human    95 VNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNL 159
            |::.::..:|||:.|||..|::||.:||..:|.|::...|.||.:.|||||::||.....|...:
  Fly   160 VDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTV 224

Human   160 LVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQ 224
            |:|:.|||.|:.....||:.||..|...|:.:.|:|..:|:..:|..|::|.|||.:.||:|.:|
  Fly   225 LLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIPALLFFISIFGWEHFTGKRDLLPGQCAVQ 289

Human   225 FLSEPTITFGTAIAAFYMPVTIMTILYWRIYK---ETEKRTK----------------------- 263
            ||.:|.......|..::..:.::.:||..|||   :.:||::                       
  Fly   290 FLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGH 354

Human   264 ----------------ELAG---------------LQASG----TEAETENFVHPTGSSRSCSSY 293
                            ||||               |..||    ....||.....|...|..|:.
  Fly   355 AAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAA 419

Human   294 ELQQQSMKR-------------------------------------SNRRKYGRCHFWF------ 315
            ::|:::.||                                     :|.||.......|      
  Fly   420 KIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQAQQLITQQKLNNMRKRSSIGLVFGAQAAL 484

Human   316 ------------TTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDE-------------- 354
                        ||.|  .|.|.|.|.|......:|.   :.|:.:.|.:|              
  Fly   485 LATRGKGNLQKSTTNS--KSIEAMHQYHHHQQHHHNQ---SPLQRAQSKEEMRSLHHHQNQQQPH 544

Human   355 ---------EDIGSETRAIYSIVLKLPGHS---------TILNS--------------------- 380
                     ..:....|...|.:.::..|.         |:||:                     
  Fly   545 HQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLLNTSDPLSPVDLAPIEVPSDQVHQ 609

Human   381 ----TKLPSSDNLQVP-----------------------------EEELGMVDLERKA------- 405
                |.||..|..|.|                             ..||..:| |..|       
  Fly   610 GLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYDLMTNSELRYMD-ESSAMLASVTA 673

Human   406 -------DKLQAQ--------------------------------------------------KS 413
                   |.:|.:                                                  :|
  Fly   674 NSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNLNPNHNQSQSQS 738

Human   414 VDDGGSFPK----------SFSKL----------------------------------------- 427
            :::..:..|          .|:|:                                         
  Fly   739 IEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRASSPMETSSKDAILY 803

Human   428 ------------------------------PIQLESAVDTAKTSDVN-----------SSVG--- 448
                                          |:.|| .::..:|||.|           ||.|   
  Fly   804 SPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLE-RIEERETSDSNTNKMPSTSGTTSSTGGVG 867

Human   449 ------------------------KSTATLPLSFKEA---TLAKRFALKTRSQIT-----KRKRM 481
                                    ||.|....|.|.|   ::.|.|..|....:.     ::|..
  Fly   868 GGGEQDGVGATKKNAGDDDANREEKSLAASRNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSK 932

Human   482 SLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFC--DSCIPKTFWNLGYWLCYINSTVNPVCY 544
            |..:.:||.:|:|.||..|:..||||:::.||..||  ..||.:..:...|:|||.||.:||.||
  Fly   933 SENRARKAFRTISFILGCFVACWTPYHVLALVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCY 997

Human   545 ALCNKTFRTTFKMLL 559
            ||.|:.|:.||..:|
  Fly   998 ALANQQFKKTFTRIL 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRM3NP_000731.1 7tmA_mAChR_M3 66..>270 CDD:320426 78/260 (30%)
TM helix 1 70..96 CDD:320426 10/25 (40%)
TM helix 2 103..130 CDD:320426 13/26 (50%)
TM helix 3 141..171 CDD:320426 14/29 (48%)
TM helix 4 183..206 CDD:320426 6/22 (27%)
TM helix 5 228..257 CDD:320426 7/31 (23%)
Basolateral sorting signal 275..281 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..357 9/56 (16%)
7tm_GPCRs <484..564 CDD:475119 34/78 (44%)
TM helix 6 490..512 CDD:320426 9/21 (43%)
TM helix 7 523..548 CDD:320426 12/24 (50%)
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 66/175 (38%)
TM helix 2 168..194 CDD:320429 12/25 (48%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 6/22 (27%)
TM helix 5 293..322 CDD:320429 6/28 (21%)
7tm_GPCRs <932..1008 CDD:475119 32/75 (43%)
TM helix 6 941..963 CDD:410628 9/21 (43%)
TM helix 7 976..1001 CDD:410628 12/24 (50%)

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