DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHRM3 and mAChR-A

DIOPT Version :10

Sequence 1:NP_000731.1 Gene:CHRM3 / 1131 HGNCID:1952 Length:590 Species:Homo sapiens
Sequence 2:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster


Alignment Length:793 Identity:253/793 - (31%)
Similarity:347/793 - (43%) Gaps:243/793 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     7 STTSPLFPNI-----------SSSWIHSPSDAGLPPG------TVTHFGSYNVSRAAGNFSSPDG 54
            |...|||..:           :|:...:.|.||..||      ....|.:...:.|:|.:....|
  Fly    16 SILEPLFKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSG 80

Human    55 TTDDPLGG----------HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLS 109
            ...:...|          :::..:|.:.|:..||:.||:.||::|::|||::|||:|::||||.|
  Fly    81 MYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFS 145

Human   110 LACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPL 174
            ||.||..||.|||.||....|:..|.||.:.||.|||:||:||||||:|||:||||||||:||||
  Fly   146 LAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPL 210

Human   175 TYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFL-SEPTITFGTAIA 238
            ||||||||.||.||||.||.||.:||.|.|..|.|..||||||..||:|||: :...||||||:|
  Fly   211 TYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALA 275

Human   239 AFYMPVTIMTILYWRIYKETEKRTKELAGLQA------SGTEAETENFV--HPTGS--------- 286
            |||.|||||..|||||::||:||.|:|..|||      ..:.:..||.|  |.:|.         
  Fly   276 AFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGG 340

Human   287 --------SRSCSSYELQ-------------------QQSMKRSNRRK-----YGR----CHFWF 315
                    .||.||.:.:                   :.|:|.:|..|     :|.    |..| 
  Fly   341 NDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAW- 404

Human   316 TTKSWKPSSEQMD-----QDHSSS---------------------------DSW----------- 337
                |....|..|     |:..|.                           |::           
  Fly   405 ----WHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRP 465

Human   338 -------------------------------------------------NNNDAAASLENSASSD 353
                                                             |||:|:.:...:.:.:
  Fly   466 PSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGN 530

Human   354 EEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNL---QVPEEELGMVDLERKADKLQAQKSVD 415
            ....||      .|.|...|::|..:|..||..:.:   .|.::.:..:.:...:|. .:..:.:
  Fly   531 GAGNGS------GIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDG-ASSNAAN 588

Human   416 DGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKST--ATLPLSFKEAT--------------LA 464
            .||..|.:.:.....|....|.|.:..:....|.:|  |..||:...||              |.
  Fly   589 GGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLG 653

Human   465 KRF-----------------------------------ALKTRSQITKRKRMSLVK--EKKAAQT 492
            :|.                                   ||.......|:|:.|..|  |.|||:|
  Fly   654 RRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKT 718

Human   493 LSAILLAFIITWTPYNIMVLVN--TFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTF 555
            ||||||:||||||||||:||:.  |.|..|||...|:..|.|||||||:||:||||||.|||.|:
  Fly   719 LSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTY 783

Human   556 KMLLLCQCDKKKR 568
            ..:|.|:...:.|
  Fly   784 VRILTCKWHTRNR 796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRM3NP_000731.1 7tmA_mAChR_M3 66..>270 CDD:320426 126/204 (62%)
TM helix 1 70..96 CDD:320426 11/25 (44%)
TM helix 2 103..130 CDD:320426 16/26 (62%)
TM helix 3 141..171 CDD:320426 24/29 (83%)
TM helix 4 183..206 CDD:320426 14/22 (64%)
TM helix 5 228..257 CDD:320426 20/28 (71%)
Basolateral sorting signal 275..281 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..357 9/125 (7%)
7tm_GPCRs <484..564 CDD:475119 52/83 (63%)
TM helix 6 490..512 CDD:320426 18/21 (86%)
TM helix 7 523..548 CDD:320426 15/24 (63%)
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 123/194 (63%)
TM helix 1 106..132 CDD:320428 11/25 (44%)
TM helix 2 139..165 CDD:320428 16/25 (64%)
TM helix 3 177..207 CDD:320428 24/29 (83%)
TM helix 4 219..242 CDD:320428 14/22 (64%)
TM helix 5 265..294 CDD:320428 20/28 (71%)
7tm_GPCRs <707..783 CDD:475119 49/75 (65%)
TM helix 6 716..738 CDD:410628 18/21 (86%)
TM helix 7 751..776 CDD:410628 15/24 (63%)

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