Protein Alignment SLCO2B1 and Oatp74D

DIOPT Version :10

• Sequence 1: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Sequence 2: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 709
• Identity: 194/709 - (27%)
• Similarity: 313/709 - (44%)
• Gaps: 117/709 - (16%)

Human    69 FHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFG 133
            |.:..:|::...|..:.|.|...|..|.|:|:||.|.:.|:|:|:|.|.:|:|.....:.::||.
  Fly   170 FASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFA 234

Human   134 SRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSN 198
            .|.||||.|..|.:|.::|.....|||||..            .|...:|:.|..|.  .|.|:|
  Fly   235 GRGHRPRWIACGMVLFSIAAFSCALPHFIFG------------EQLMHSSVILQQTQ--VSPPNN 285

Human   199 G------NCSSYTETQHLSVVG------------------------------IMFVAQTLLGVGG 227
            .      |.||.....:|.::|                              |.|.:....|:|.
  Fly   286 SFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQ 350

Human   228 VPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIK 292
            ..:...||.||||...:..||:|:.:...:.::||...|..||...|.||:.:   ..|...|
  Fly   351 TAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFS---NPGFDAT-- 410

Human   293 DPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQ- 356
            ||||:||||||.:.....:.||:|..|.|||::                      :||..|..|
  Fly   411 DPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQL----------------------RGKQKPPGQT 453

Human   357 ----SPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATF 417
                :|.|..:|        |.|      |.||:.:.:.|.:.|.:....|.|......||:.||
  Fly   454 ATPAAPVEPEEK--------PKL------KDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTF 504

Human   418 LPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFS- 481
            |||:||.||.:....||::........:.:|||:.|:.:  |...|...|....:.....::.:
  Fly   505 LPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGLFI--LKRKPTARGVAAWIAFTALVYSAG 567

Human   482 -LPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEA--CSCPLDGFNPVCDPSTRVEYITPCHAG 543
             :.|.|||||.:..||........|.| :.|:|..|  |:|..:.|.|:|.....  ||:.||||
  Fly   568 MIILMFIGCSMNDFAGYKPSDGNSPAL-IEPTCSAALNCTCDKENFAPICADGKM--YISACHAG 629

Human   544 CSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFM 608
            |||..::.: || :..|::|:|:.:....:.|.||:.|.:.:. |:|:.::...:...:...|.:
  Fly   630 CSSSSLRPS-DN-RTLYSDCACIPDAPEAVNGYCDNNCKNFIY-FILIFAICVFMHSTSEVGSML 691

Human   609 LILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRN 673
            |::|....:||.:|:|:....:.:...:|.|:|:|:.:|:.|:.|...||:...|..|:.|..|.
  Fly   692 LVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQ 756

Human   674 RFIGLQFFFKTGSV--ICFALVLAVLRQQDK--EARTKESRSSPAVEQQLLVSGPGKKP 728
            .|:|:     |..:  :.|.:.|.|.|:..:  .|........||...:.|.....|:|
  Fly   757 YFLGI-----TAGIMFLAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQP 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	162/584 (28%)
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	179/641 (28%)