Protein Alignment SLCO2B1 and Oatp58Db

DIOPT Version :10

• Sequence 1: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Sequence 2: NP_611658.3
• Gene: Oatp58Db / 37544
• FlyBaseID: FBgn0034715
• Length: 680
• Species: Drosophila melanogaster
• Alignment Length: 748
• Identity: 188/748 - (25%)
• Similarity: 322/748 - (43%)
• Gaps: 149/748 - (19%)

Human    38 VPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEK 102
            |.|.| |....::.|.|......|...|.:..|   :||:.:.:......|...|...:|:|:||
  Fly    21 VADDE-KRLNSSDTTCGFSIFRGPALQRFATAH---MFVIVYGIASCFLAMAFTYFTGTITTMEK 81

Human   103 RFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFI----S 163
            ||.:.::.|||:...|::.......|:||:.||.||||.:..|.|::|:..|||..||..    .
  Fly    82 RFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGE 146

Human   164 EPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNC----SSYTETQHLSVVGIMFVAQTLLG 224
            |..|.  |....|.:.|.|||.:...:.......|.||    ..||.      :.:.|:||.:.|
  Fly   147 EALRL--TEEYGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTP------IVLFFIAQFIGG 203

Human   225 VGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISL 289
            :|.......|:||:||.:.:|.:|..|.....:.|:||.:.|.:.||.||||:|..:.|    .:
  Fly   204 IGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYIDPFKKP----LI 264

Human   290 TIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPS 354
            |..||||:||||:|:::....:.::|:....||||||:.|                ||:.|....
  Fly   265 TTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMPRAK----------------ARRLKADGE 313

Human   355 KQSP--GESTKKQ-DGLVQIAPNLTVIQFIKVFPRVLLQTLRH-----PIFLLVVLSQVCLSSMA 411
            :..|  |.|.:.. |.|.::|.|       ||:...:|.::.:     |.::
  Fly   314 EDIPLAGRSFQDMLDSLKRLASN-------KVYVYNMLASILYLFGYMPYWI------------- 358

Human   412 AGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGA-------L 469
                 |.||::|.|:..:||.:.:..|..:......||::.|.::.:.........|       |
  Fly   359 -----FTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYL 418

Human   470 CLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSP---SCMEACSCPLDGFNPVCDPS 531
            .:.|||..:       .:||.....|.         .|.:.|   ||..:|.|....:.|||.|.
  Fly   419 TVAGMLCYV-------LVGCDESDRAN---------SLSIVPTGDSCSASCVCEYVYYAPVCSPE 467

Human   532 TRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLA----------------GSCDST 580
             .:.:|:.|||||:...:.:.   .:..||.|.|:...:.:::                |:|...
  Fly   468 -NITFISACHAGCTDKAINEL---GKTIYTGCRCMGNVSSIISLSNVTSLASQSQIAMDGACPVD 528

Human   581 CSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSA 645
            |:...:.||.::.....:.....:.:.:|.||.|..:|||.::|...|...:||::|||::.|..
  Fly   529 CNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWM 593

Human   646 IDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALV-------LAV------L 697
            :|:.|:.|..:|..:..|..|:...||          .|.:::|.:|:       :.|      :
  Fly   594 LDSYCLVWGKTCSSKGNCWIYDTKSLR----------YTMNLVCASLIFLGSFWNIGVWYHAKDM 648

Human   698 RQQDKEARTKESRSSPAVEQQLLVSGPGKKPED 730
            :..|::.:|.:::.|..:|.:       :||.|
  Fly   649 KVFDEDEKTVQAKQSDDIELK-------EKPND 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	146/581 (25%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:460821	166/638 (26%)