Protein Alignment SLCO2B1 and Oatp58Da

DIOPT Version :10

• Sequence 1: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Sequence 2: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 772
• Identity: 180/772 - (23%)
• Similarity: 315/772 - (40%)
• Gaps: 152/772 - (19%)

Human     7 MQLSRSQPYFTQSLLKMKMEMEMGPAGEVPQVPDKETKATMGTENTPGGKAS-------PDPQDV 64
            ::.|.:.|:..:.......|.|..|..|              ||...|||.:       ..|...
  Fly    10 LEKSETLPFIEKPFAISDKERESAPENE--------------TEGEDGGKDTYCGFWIFKGPSMQ 60

Human    65 RPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFV 129
            |.:..|   ::|:.:.|......|...|...:|:|:|||:.:.::.||:::..|::........:
  Fly    61 RFATEH---MYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGNDISTMLTAAIL 122

Human   130 SYFGSRVHRPRMIGYGAILVALAGLLMTLPHF----------ISEPYRYDNTSPEDMPQDFKASL 184
            .|:....||||.:|.|.:.:....||.:..||          ::..:...|.:..:..:|.|  |
  Fly   123 GYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETLTNQERDKK--L 185

Human   185 CLPTTSAPASAPSNGNCSSYTETQHLSVVGI------MFVAQTLLGVGGVPIQPFGISYIDDFAH 243
            |.||.         |.|..       ..||:      :|.||.:.|||.......||:|:||...
  Fly   186 CQPTA---------GGCVQ-------EEVGLWVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTS 234

Human   244 NSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAA 308
            .:.:|..|.:...:.|:||.:.:.|.::.||||::....|..|    .:||||:||||||:|:.|
  Fly   235 KAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPLIG----QEDPRWLGAWWLGWLVLA 295

Human   309 GAVALAAIPYFFFPKEMPK-EKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIA 372
            ....::||..|.|||::|. .||.||.               |....|||...:.:....:::..
  Fly   296 AITLVSAILLFMFPKQLPSARKRRLQL---------------KQDERKQSLPLNERSLADMMKTV 345

Human   373 PNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLI 437
            ..|:                ::.:::...::.:...........|.||::|.|:..:|:.|.:..
  Fly   346 KKLS----------------KNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMAT 394

Human   438 GCLSFPSVIVGIVVGGVLVKRLHLGPVG---------------CGALCLLGMLLCLFFSLPLFFI 487
            |.::......||::.|.::.:..  |..               .|.||.:.             |
  Fly   395 GTVALGFSAAGILISGYVISKYK--PSARAMAAWNAIVDFVTVAGILCYVA-------------I 444

Human   488 GC-SSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQD 551
            || .|.::..:|       .|....||..:|.|....:.|||. :..:.:|:.||||||. ..:|
  Fly   445 GCEGSDRLNTLT-------TLSAGNSCSASCHCDYVHYAPVCS-ADNITFISACHAGCSE-RTKD 500

Human   552 ALDNSQVFYTNCSCV--------VEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFM 608
            ||  .:..||.|.|:        .|....:.|:|...|.:..:.||.::.....:...:.:.:.:
  Fly   501 AL--GRTIYTGCECLGSSSLNSEPESQFAVDGTCPVDCFNEFLIFLGVMCFLKLVGASSKSTNLL 563

Human   609 LILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRN 673
            |.||.:..::||.|:|:..|...:|.::|||:..|..||..|:.|..:|..:..|..|:...:|.
  Fly   564 LALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSMRY 628

Human   674 RF-IGLQFFFKTGSVICFAL-----VLAVLRQQDKEARTKESRSSPAVEQQLLVSGP 724
            .. :...||...|..:..|:     .|.:.  .::|:..|:|..:..||.:.:.|.|
  Fly   629 ALNLSAAFFIFLGGFLNIAVWYHAKNLKIF--DEEESSPKDSLKNKEVEMKTIDSNP 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	134/580 (23%)
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	153/637 (24%)