Protein Alignment SLCO2B1 and Oatp33Eb

DIOPT Version :10

• Sequence 1: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Sequence 2: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 649
• Identity: 154/649 - (23%)
• Similarity: 268/649 - (41%)
• Gaps: 149/649 - (22%)

Human    69 FHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALI------- 126
            :..::.|:|.        |.|||.|:.:   .|..|.:|::.    |||....|..::
  Fly    43 YARLRTFILV--------LAISGTLQGA---CESYFRVSAKQ----ASFQFGWNPLIVDWLLVAS 92

Human   127 -----VFV---SYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKAS 183
                 ||.   :|:....|..:.:....:|.|:..::..:|..::..   |....:|...|  |:
  Fly    93 GLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFA---DGNQAKDALLD--AN 152

Human   184 LCLPTTSAPASAPSNGNCSSYTETQHLSV-VGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNS 247
            :|       |::.:.....:.||.|..|: :.::||.|..||:||:.....|:|||||.:.:.:|
  Fly   153 MC-------ATSLAQFQRLTLTEAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDS 210

Human   248 PLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVA 312
            |..:|...|..:.|.    ..||.::.           |:.||     .|| ||||::|.|..:.
  Fly   211 PAVIGAALAARVFGQ----QAGSFLVL-----------GVGLT-----HVG-WWLGWVILAPFIF 254

Human   313 LAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGE--STKKQDGLVQIAPNL 375
            :.|:....|||.:||            .|....|::..:..|.:..|.  ||...|.  ...|:|
  Fly   255 VGAVLLGLFPKRLPK------------TVIHQAAQRIIEQSSMRRFGSQFSTYMDDS--DFWPSL 305

Human   376 TVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQF--------SITASY 432
            .     ::|...||        :..:||.:|:.|...........:|:.:|        .:.|.:
  Fly   306 K-----RLFNNRLL--------MFNLLSIMCVQSAVVNYGLQEESYLQSRFFLPYNEQDGLAAEW 357

Human   433 ANLLIGCLSFPSVI-VGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIG-----CSS 491
            .:..:.....|.|: :|:::.|:::.:..|     .|..:.|:.:.|...|...|||     |..
  Fly   358 RSAFVSYFLKPPVMALGMLISGLVISKAKL-----SARKITGINIALSIHLVAIFIGLIFVQCDV 417

Human   492 HQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNS 556
            ..|||:      ..|....|.|...|.|....|.|||..::.|.|.:||:|||:.   :..:::.
  Fly   418 GAIAGV------EGGKLKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTK---KTTINSF 473

Human   557 QVFYTNCSCVVEGNPVL---------AGSCDS-TCSHLVVPFLLL---VSLGSALACLTHTPSFM 608
            |:| ..|||  .|:..|         ||:|.| .|...::.|.::   |:....:..:..|   :
  Fly   474 QLF-EGCSC--SGDQSLNSTGQMRATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKT---L 532

Human   609 LILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLR 672
            :.||.|..:||:||:..:.|.:.:.|::|..:.:.....||||:||.:         |...|||
  Fly   533 ITLRAVLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPN---------YERCLLR 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	134/584 (23%)
Oatp33Eb	NP_609570.1	MFS_SLCO_OATP	46..536	CDD:340894	134/584 (23%)
		PHA03247	<635..813	CDD:223021