Protein Alignment SLCO2B1 and Oatp33Ea

DIOPT Version :10

• Sequence 1: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Sequence 2: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Alignment Length: 735
• Identity: 196/735 - (26%)
• Similarity: 313/735 - (42%)
• Gaps: 143/735 - (19%)

Human    73 KLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVH 137
            |:|:..:.||...|.|...|...:::|:||||.:.|||:|::.|.||:....|.:.:||.|.:.:
  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99

Human   138 RPRMIGYGAILVALAGLLMTLPHFI----SEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSN 198
            |||.|.:|.:...|:..::.|||||    .|..::        .::::.||...||   .|..|.
  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQF--------TKEYQDSLLNGTT---GSDHSF 153

Human   199 GNCSSYTETQHLSVVG----------------IMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNS 247
            .|.|| .:|:.|..|.                ::|::|.:||||.......|.:|:||....:|:
  Fly   154 QNISS-VKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNT 217

Human   248 PLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVA 312
            ||.|.:..|:.|:||.:.|..|.:.|..::|..:.|    .:..|||||:||||||::|....:.
  Fly   218 PLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTP----LIDSKDPRWLGAWWLGWVILGTLMC 278

Human   313 LAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPAR-KGKDSPSKQSPGESTKKQDGLVQIAPNLT 376
            |.:.....|||::||...........||:..:... |.:::.|..|...|....|.:...|....
  Fly   279 LFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANA 343

Human   377 VIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLS 441
            .:..:|.|||.|::.||:.:.:..:||.|.....|:|..|||.|::|.||...|..|.:::|.:|
  Fly   344 DLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPIS 408

Human   442 FPSVIVGIVVGGVL-------VKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITH 499
            ...::||::..|::       |.::.:..|..|.:.:||.:...|...|..|....:.|
  Fly   409 IMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNTFSMTQAGQ------ 467

Human   500 QTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCS 564
                   |.|:.:|...|||....:.|||...|...:.:.|||||..:.....|      |.:||
  Fly   468 -------LNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSKL------YEDCS 519

Human   565 CVV----------------------------------EGNPVL---------------------- 573
            |||                                  .|.|:|
  Fly   520 CVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSV 584

Human   574 --AGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWM 636
              .|.|...|:.....|.:...:.|.........:.::..|.|..|||:.|.|:..|.:.:||.:
  Fly   585 IRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALI 649

Human   637 PSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRN---------RFIGLQFFFKTGSVICFAL 692
            |.|:|.|..||:||:.|..:|.....|:.|:....|.         .|:||.|.:         |
  Fly   650 PGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDY---------L 705

Human   693 VLAVLRQ----QDKEARTKE 708
            |....|.    .||||:.:|
  Fly   706 VWYYGRNLDIYGDKEAKEEE 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	161/624 (26%)
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	182/682 (27%)