Protein Alignment SLCO2B1 and Oatp30B

DIOPT Version :10

• Sequence 1: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Sequence 2: NP_609293.2
• Gene: Oatp30B / 34268
• FlyBaseID: FBgn0032123
• Length: 1197
• Species: Drosophila melanogaster
• Alignment Length: 797
• Identity: 245/797 - (30%)
• Similarity: 385/797 - (48%)
• Gaps: 114/797 - (14%)

Human    12 SQPYFTQSLL--KMKMEMEMGPAGEVPQVPDKETKATMGTENTPGGKASPDPQD----------- 63
            |||:.|..|.  ::...:..||.|..|............:.....||...||::
  Fly    88 SQPHATSYLAGDQLPSTVGSGPGGGGPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFRSGD 152

Human    64 -----VRP---SVFHNIKLFVLCHSLL-QLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNE 119
                 .||   ..|..||:||:..||| .:.|.:.|||:.|.|:|:||||.:.|..|||:||..|
  Fly   153 CGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYE 217

Human   120 VGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEP--------YRYDNTSPEDM 176
            :||...::||||.|||.|.|..||.||:::.:..|:..:|||..||        ...||.....:
  Fly   218 IGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSAL 282

Human   177 PQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVG--------IMFV-AQTLLGVGGVPIQP 232
            .:|....|     ...:|..||...:.:|..:...:.|        ::|| ||.|||.||.|:..
  Fly   283 VRDQDMDL-----GRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFT 342

Human   233 FGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWV 297
            .|.:|:||.....:|.:|:|.::::...||.:.|.||:.:|..::|  .:....||:|..|.|||
  Fly   343 LGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWV 405

Human   298 GAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAV--TDSPARKGKDSPSKQSPGE 360
            |.||.|||:....:.:.|:|:|.|||.:.:||::::....|..|  .:|.|....|...|....|
  Fly   406 GMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLE 470

Human   361 ---STKKQDGLVQIAPNLTV--IQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSM-AAGMATFLP 419
               .|.|:| ..|..|.:..  .:.||..|:.:|:.:::|::::..|. .|:..| .:|...|||
  Fly   471 IVAVTSKED-QSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLG-ACMELMIVSGFVVFLP 533

Human   420 KFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPL 484
            |:||.|||:..|.||:..|.::.|...:||.:||.::||..|.|.|.....|:..::||.....|
  Fly   534 KYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAML 598

Human   485 FFIGCSSHQIAGIT--HQTSAHPG--------LELSPSCMEACSCPLDGFNPVCDPSTRVEYITP 539
            ||:||.:.::||.|  :.||...|        :.|:.:|...|.|......|||. :..:.|.:|
  Fly   599 FFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCG-NNGLTYFSP 662

Human   540 CHAGCSSWVVQDALDNSQVFYTNCSCV-------------------VEGN---------PV-LAG 575
            |||||:::     ...|...||||:||                   :..|         || .||
  Fly   663 CHAGCTAF-----SSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAG 722

Human   576 SCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPV 640
            .|.:.| ..:.|||:|:...:.|...|..|..|::||.|.:|:::.|:|:||:..|:..::|:|:
  Fly   723 PCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPI 786

Human   641 IHGSAIDTTCVHWALSCGRR-AVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVL------AVLR 698
            :.|:.||:||:.|..|||.: ..|..|:.:..|.:::||     ..||...|||:      .|.|
  Fly   787 LFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGL-----CASVKLIALVIFMVDWWLVRR 846

Human   699 QQDKEARTKESRSSPAV 715
            ::..|.....:.|.|.:
  Fly   847 RKQLEKMKPLNASDPII 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	194/604 (32%)
Oatp30B	NP_609293.2	MFS_SLCO5_OATP5	170..758	CDD:340962	193/603 (32%)
		UhpC	<730..795	CDD:441872	22/64 (34%)