Protein Alignment SLCO2B1 and Oatp26F

DIOPT Version :10

• Sequence 1: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Sequence 2: NP_609055.2
• Gene: Oatp26F / 33927
• FlyBaseID: FBgn0051634
• Length: 692
• Species: Drosophila melanogaster
• Alignment Length: 653
• Identity: 203/653 - (31%)
• Similarity: 312/653 - (47%)
• Gaps: 85/653 - (13%)

Human    74 LFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSR--V 136
            ||.||.. ..|..|:::|.:..||||:|:||||.|:..||:||..::.:.|.:|.|:|:|.|  .
  Fly    68 LFWLCWG-GALQGLIVNGLINVSISTIERRFGLRSRQMGLVASGYDLASFACLVPVTYYGGRRGA 131

Human   137 HRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNC 201
            .:||.|..|.|::.:..|:..||:|:...||  .|..|       |::|..|     ..|.|.|.
  Fly   132 SKPRFIAIGLIVMGMGSLVFLLPNFLVGNYR--ATIAE-------ANVCETT-----GLPFNSNS 182

Human   202 SSYTETQHLSVVG------------IMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGIL 254
            |.......|:.:|            :...||.|.|.|..|:...|::|||:......|.:||||.
  Fly   183 SQSMTACELNAMGEGQSENLTWTVWLFLAAQLLHGAGASPLFTLGVTYIDENVSKKMSSVYLGIY 247

Human   255 FAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYF 319
            :.:..:||.:.:..|..:|.:|.|...:....:|||.....|:|||||||:.||....|.|:|.|
  Fly   248 YTMATVGPAIGYVFGGQLLLIYTDWMTVDPVQLSLTSDSKVWIGAWWLGFIFAAAMCLLIALPIF 312

Human   320 FFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVF 384
            .:||.:|..:: ||..|    |:::.|...:...|.                       ..::..
  Fly   313 GYPKLLPGAEK-LQLER----VSEAHATISEADDSS-----------------------NVVRGL 349

Human   385 PRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGI 449
            ||.:|..|.:|.|..:.|:......:.||.|.||||.:|.||||:..|:.|::|.::.|:...|.
  Fly   350 PRAVLSLLANPTFFFLNLAGATEGLVIAGFAAFLPKQIENQFSISPMYSALVMGLITVPAGGGGT 414

Human   450 VVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLE---LSP 511
            .:||.|||:.:|...|...:|||...:...|:: .|.:.|.:.:.||:|......|..:   |..
  Fly   415 FLGGYLVKKWNLACRGIIKMCLLATTVAALFTI-CFLVSCPNPKFAGVTTGYKMQPSSDSPALVA 478

Human   512 SCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSC------VVEGN 570
            ||...|.|....::|:|... .|.|.:||:|||    ||:...||...|.||||      |.:||
  Fly   479 SCNSNCGCSRTNYDPICGVD-GVMYYSPCYAGC----VQEEHANSLKRYHNCSCIEQVGFVDDGN 538

Human   571 P----------VLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGI 625
            |          .....|||||..|.: |:.|..:......|...|:....||.|:.:.::.|:|:
  Fly   539 PSSEAPHFRPDATNRKCDSTCQTLPL-FVALCFILMVFTFLATMPALSATLRCVQDDQRSFALGL 602

Human   626 QFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRA--VCRYYNNDLLRNRFIGLQFFFKTGSVI 688
            |::.:|:|..:|:|:|.|:.||.:|:.|..||.:.|  .|..|:|..:......|....|.|||:
  Fly   603 QWIKVRLLGTIPAPLIFGALIDESCILWQESCDKDAGGACLVYDNFYISRYMWLLALICKLGSVV 667

Human   689 CFA 691
            .||
  Fly   668 FFA 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	174/570 (31%)
Oatp26F	NP_609055.2	MFS_SLCO4_OATP4	64..589	CDD:340961	174/570 (31%)