Protein Alignment Abca4 and Eato

DIOPT Version :10

• Sequence 1: NP_031404.1
• Gene: Abca4 / 11304
• MGIID: 109424
• Length: 2310
• Species: Mus musculus
• Sequence 2: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Alignment Length: 1913
• Identity: 485/1913 - (25%)
• Similarity: 790/1913 - (41%)
• Gaps: 526/1913 - (27%)

Mouse   505 ITDRFLRLANQYLECLV------LDKFESYDDEVQLTQRALSLLEENRFWAGVVFPGM---YPWA 560
            |...|..:...||...|      :::||:.::.|         |.|      :.|||.   |.:.
  Fly    30 ICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMV---------LRE------LYFPGNELDYIYY 79

Mouse   561 SSLPPHVK---YKIRMDIDVVEK-------------------------------TNKIKDRYW-- 589
            |.:.|:|:   ..:|:|:.::.:                               .|:..||.:
  Fly    80 SPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCFAIDFHRVPNRGSDRKFRY 144

Mouse   590 ---DSGPRADP-------------VEDFRYIWGGFAYLQDMVEQGIVKSQMQAEPPIGVYLQQMP 638
               .:..|..|             ::|..||..||..||.::::..:|.| :......|.:..||
  Fly   145 SLSSNQMRISPRKRFVNDEEIYHQIDDDDYIRSGFLSLQHILDKQYMKYQ-ELGKDFEVVVSSMP 208

Mouse   639 YPCFVD-DSFMIIL--NRCFPIFMVLAWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTW 700
            ....:. ||..:..  ..|..:|.|:.    :|..|...|.||:..|||.|......:.:...|:
  Fly   209 NMEVISMDSHRLTYFGTLCSILFNVVL----LSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTF 269

Mouse   701 FLDSF-SIMALSIFLLTLFIMHGRILHYSDPFILFLFLLAFATATIMQSFLLSTLFSKASLAAAC 764
            ||..| ....|.||:|.:..::..:......::..||||          ::|||: |.|.|.:.|
  Fly   270 FLIRFVCYTLLMIFVLVVAYLYKALGSICFAYVAVLFLL----------YILSTM-SYAYLISIC 323

Mouse   765 SGVIYFT-------LYLPHVLCFAWQDRMTADLKTTVSLLSSVAFGFGTEYLVRFEEQGLGL--Q 820
            ...:::.       |.:|:...|         :::..:.|:.|.|...| :|     :||.:  .
  Fly   324 FHSVFYAKIGGLAMLIIPYAFSF---------VRSWATSLAFVCFSTNT-FL-----EGLDIFQT 373

Mouse   821 WSNIGKSPLEG--DEF-------SFLLSMKMMLL-DAALYGLLAWYLDQVFPGDYGTPLPWYFLL 875
            :||..|:...|  |.|       |.:.|:.::|: .:.||.:|..||..||||..|...|.:|.|
  Fly   374 FSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFL 438

Mouse   876 QESYWLGGEGCSTREERALEKTEPLTEEMEDPEHPEGMNDSFFERELPGLVPGVCVKNLVKVFEP 940
            .                  .||....:..|....|.|.:             .:.:..|.|.|:.
  Fly   439 D------------------PKTYMKRQRNEYTTTPRGTH-------------AIIITELCKKFQT 472

Mouse   941 SGRPAV--DRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLIGGKDIETNLDVVRQ 1003
            |.|..:  |.||:|....:||..||||||||||.::::.||:|..||.:::..   |.::...|.
  Fly   473 SKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRH 534

Mouse  1004 SLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQR 1068
            .:|.||||::...::|..:|:.|:|||:|....:|:...:..|:..||..||||..::|||||:|
  Fly   535 LIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKR 599

Mouse  1069 KLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAII 1133
            :||:.||..|::|:|:||||:||:|..|||.:||:||..|..:.::::||:|:||::|||.|.|:
  Fly   600 RLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICIL 664

Mouse  1134 SQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRGGCEGVCSCTSKGFSTRCPTRVDEITEE 1198
            :.|:|...|:||.||...|.|:.|.|                               .:::.|..
  Fly   665 ANGKLQSIGSPLELKRKSGIGYRLKL-------------------------------EINDFTSR 698

Mouse  1199 QVLDGDVQELMDLVYHHVPEAKLVECIGQELIFLLP--NKNFKQRAYASLFRELEETLADLGLSS 1261
            :|      |:|::::|.||.|:::..:...:...||  .||    .:|.:...||....:||:.:
  Fly   699 EV------EIMEIIHHFVPTARVLNVVNPTVYICLPYAYKN----CFAQMLYRLETESKELGIHT 753

Mouse  1262 FGISDTPLEEIFLKVTEDAGAGSMFVGGAQQKREQAGLRHPCSAPTEKLRQYAQAPHTCSPGQVD 1326
            ..::||.||::||:                           |:...:               |||
  Fly   754 ISMTDTSLEDVFLR---------------------------CAGEQD---------------QVD 776

Mouse  1327 PPKGQPSPEPEDPGVPFNTGARLILQHVQAL--------LVKRFHHTIRSRKDFVAQIVLPATFV 1383
            .|.|..:..|             :|.|.:.|        |.:.:......:..|::.     .::
  Fly   777 TPDGSRNDAP-------------LLAHYKRLQDHPPHRGLFQLWMAVFYKKWTFISN-----EWL 823

Mouse  1384 FLALMLSI-IVPPFGEFPALTLHPWMYGHQYTFFSMDEPNNEHLEVLAD------VLLNRPGFGN 1441
            :..:||.| .|..||..  |.:|.         .|:.| |.|.|.:...      :.::.| .|:
  Fly   824 YTLIMLCIPFVCVFGAI--LVMHA---------MSLVE-NEEALPLKLSQMGSGVIYVHNP-TGH 875

Mouse  1442 RCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPSCKCSTREKLTMLPECPEGAG 1506
            ....|:.|.:...:|..:.||       .||                              .|:.
  Fly   876 HAHLEQQLRQQIELNGITAKT-------MHL------------------------------RGSN 903

Mouse  1507 GLPPPQRTQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPAIPIS 1571
            .:        ..|.| ||...|::|:|
  Fly   904 DV--------KNESL-DLQRDNLADFL-------------------------------------- 921

Mouse  1572 GEALVGFLSGLGQMMNVSGGPVTREASKEMLDFLKHLETTDNIKVWFNNKGWHALVSFLNVAHNA 1636
             |.::|.:...|      ||..|.:              |..|:::::...:|:.|..:|:..:|
  Fly   922 -EQVIGIIDMYG------GGRGTSD--------------TPTIEIFYSGNRYHSSVELINLVDSA 965

Mouse  1637 ILRASLPRDRDPEEYGITVISQPLNLTKEQLSDITVLTTSVDAVVAICVIFAMSFVPASFVLYLI 1701
            :|:...|.    .|...|.:  |:   :..:|||:.......||:   |...|.|....|:....
  Fly   966 MLKLGRPE----SEIDTTYV--PI---RRFVSDISPSRLEYYAVI---VPIGMFFFMFYFISLPF 1018

Mouse  1702 QERVTKAKHLQFISGVSPTTYWLTNFLWDIMNYAVSAGLVVGIF----IGFQKKAYTSPDNLPAL 1762
            :|.....|.||.:|..   |||..:|.:|::   :...:.|.:|    :....:.||:.: |..:
  Fly  1019 REYANGFKQLQTMSRF---TYWFAHFTFDML---ILIFVCVALFSLQSLMMPSELYTTAE-LKVI 1076

Mouse  1763 VSLLMLYGWAVIPMMYPASFLFEVPST--AYVAL-----SCANLFIGINSSAITFVLELFENNRT 1820
            |..:..||.:.:|::|.....|:..||  .|:.|     :.|.|....|::|    ::|.|....
  Fly  1077 VLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAA----MKLHETKIA 1137

Mouse  1821 LLRF------NAMLRKL---LIVFPHFCLGRGLIDLALSQAVTDVYAQFGEEYSANPFQWDLIGK 1876
            .|.|      |...|.:   .|...|..|.:|||    ||.....||
  Fly  1138 FLCFLPDFNLNHQFRIINENFITRRHPALIKGLI----SQDTFFAYA------------------ 1180

Mouse  1877 NLVAMAIEGVVYFLLTLLIQHHFFLTR-------WIAEPAR---------EPVFDEDDDVAEERQ 1925
              .|:.:..:.:|  |::::|.:...|       |..:..:         .|: .|.||.|.|.:
  Fly  1181 --TAVGVMVMAFF--TIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPI-SEIDDCAREEK 1240

Mouse  1926 RVMSGGNKTDILK--LNE-------LTKVYSGSSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTF 1981
            ||      ||::|  ||:       |.|.|  ....|||.:......|||||||||||||||:||
  Fly  1241 RV------TDLIKDPLNDHSLIVHNLRKRY--GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTF 1297

Mouse  1982 KMLTGDTTVTSGDATVAGKSILTSISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRGV----- 2041
            :|:..:..:..|...:.|..|........:..|||||:||::..:|..:.||..|.|||:
  Fly  1298 QMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRT 1362

Mouse  2042 --PSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTAIALTGCPPLLLLDEPTTGMDPQA 2104
              |:...|.|..| ::.:.|:.|.......||||.||||..|:|:.|.|.|:||||||||:||.:
  Fly  1363 DGPASCKEHVKYW-LEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPIS 1426

Mouse  2105 RRMLWNTIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGTFQCLGTIQHLKYKFGDGYIVTMK 2169
            ||.||..|.....:.|.||||||||:|||.||.|||||..|.|:||..|..||..  .|:.:.:|
  Fly  1427 RRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLK 1489

Mouse  2170 IKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHHSMLQFQVPS-------SSLARIFQLLISHKDS 2227
            :|:..:..: :::.:....:..|||...||.|...|.:.|.:       ||:.:|.:..:..:.|
  Fly  1490 MKADTETEM-NVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLS 1553

Mouse  2228 LLIEEYSVTQTTLDQVFVNF---AKQQT 2252
            .|:.:|||.:.||:.:|:.|   ||.|:
  Fly  1554 ALVADYSVNECTLEDIFLKFEREAKSQS 1581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca4	NP_031404.1	rim_protein	1..2271	CDD:130324	485/1913 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..910		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1311..1344		6/32 (19%)
		Essential for ATP binding and ATPase activity. /evidence=ECO:0000250|UniProtKB:P78363	2243..2248		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2266..2310
Eato	NP_001036360.1	rim_protein	<169..1591	CDD:130324	461/1759 (26%)