Protein Alignment Abca1 and Eato

DIOPT Version :9

• Sequence 1: XP_006537617.1
• Gene: Abca1 / 11303
• MGIID: 99607
• Length: 2263
• Species: Mus musculus
• Sequence 2: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Alignment Length: 1882
• Identity: 477/1882 - (25%)
• Similarity: 803/1882 - (42%)
• Gaps: 452/1882 - (24%)

Mouse   456 LDWTAQDIM----AFLAKNP---EDVQSPNGSV-YTWREAFNETNQAIQTISRFMECVNLNKLEP 512
            |.|:.:.::    .|.|||.   .::..|...: |.:....:...:.|..:.|.       .|..
  Fly    42 LHWSVKPVLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRV-------DLGI 99

Mouse   513 IPTEVRLINKSMEL-LDERKFWAGIVFTGITPDSVELPHH-----VKYKI---RMDIDNVERTNK 568
            ||..:|..|.|.|: |:..:...|..|   ..|...:|:.     .:|.:   :|.|...:|...
  Fly   100 IPERLRPNNNSFEMQLEMEQQCRGSCF---AIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVN 161

Mouse   569 IKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSE--KKTGVYVQQMPYPCYVDDI 631
            .::.|       ...:|..|:..||..||.::::..::.   .|  |...|.|..||     :..
  Fly   162 DEEIY-------HQIDDDDYIRSGFLSLQHILDKQYMKY---QELGKDFEVVVSSMP-----NME 211

Mouse   632 FLRVMSRSMPLFMTLAWIYSVAVIIKSIVY----EKEARLKETMRI---MGLDNGILWFSWFVSS 689
            .:.:.|..:..|.||..|....|::.|.|.    ||:..|||.:.:   |...||:.:|
  Fly   212 VISMDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF------ 270

Mouse   690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQ----CFLISTLFSRANLAAACG 750
            ||..:....|::.:|.:..|.. :..|:.|.:::|..::.||.    .:|||..| .:...|..|
  Fly   271 LIRFVCYTLLMIFVLVVAYLYK-ALGSICFAYVAVLFLLYILSTMSYAYLISICF-HSVFYAKIG 333

Mouse   751 GIIYFTLYLPYVLCV--AWQD---YVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWD--N 808
            |:.  .|.:||....  :|..   :|.||...|..         |.:.|..|..:....::.  :
  Fly   334 GLA--MLIIPYAFSFVRSWATSLAFVCFSTNTFLE---------GLDIFQTFSNKRKNREFGAVD 387

Mouse   809 LFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEK 873
            :|. .::.:...:.:...:::|.:|||.::..|:..||||..|:.||.:|          .:|.|
  Fly   388 VFR-VIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFF----------FLDPK 441

Mouse   874 SHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMK--VAVDGLALNFYEGQITSFLGHNG 936
            ::   .::..:|.......||   .:.|..|.|.::...:  :..|.|.:.....:||..|||||
  Fly   442 TY---MKRQRNEYTTTPRGTH---AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNG 500

Mouse   937 AGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLK 1001
            |||||.|:::.||.|..||...:..:   .:::|.|..:|.||||:|....:|..:|:.|:|:|:
  Fly   501 AGKTTMMNMIMGLVPKDSGKIIVCSE---RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLR 562

Mouse  1002 GLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPY 1066
            |......:...::....:|| ..|.......|||||:|:||:.:|..|.:|:||||||::|:|..
  Fly   563 GACRSDARDWADEKLKKLGL-SDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDIN 626

Mouse  1067 SRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLV 1131
            |||.:|::||..|:.:.::::||:|:||::|||.|.|:::|||..:||.|.||.:.|.||.|.|.
  Fly   627 SRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLE 691

Mouse  1132 KKDVESSLSSCRNSSSTVSCLKKVVPGLPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEA 1196
            ..|..|.                                ||:           |..:|...|..|
  Fly   692 INDFTSR--------------------------------EVE-----------IMEIIHHFVPTA 713

Mouse  1197 RLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVA-EESGVD 1260
            |::..:...:...|||  |.:..|.::.:.::....:|||.:..:::|:||::||:.| |:..||
  Fly   714 RVLNVVNPTVYICLPY--AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVD 776

Mouse  1261 AETSDGT---LPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLK 1322
              |.||:   .|...:.:...|     ||        |:                   :|.:||
  Fly   777 --TPDGSRNDAPLLAHYKRLQD-----HP--------PH-------------------RGLFQL- 806

Mouse  1323 GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYN 1387
             |       :|:.:|:....  |.:..:..|:|...|||:          ||....:.....:.|
  Fly   807 -W-------MAVFYKKWTFI--SNEWLYTLIMLCIPFVCV----------FGAILVMHAMSLVEN 851

Mouse  1388 EQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQ 1452
            |                                 |..|:
  Fly   852 E---------------------------------EALPL-------------------------- 857

Mouse  1453 NGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQ 1517
                              |:.:|      |:|.:           .:.|.||.:..
  Fly   858 ------------------KLSQM------GSGVI-----------YVHNPTGHHAH--------- 878

Mouse  1518 IIAKSLKNKIWVNEFRYGGFSLGV-SNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSL-- 1579
             :.:.|:.:|.:|         |: :.:..|..|::|.:      :.|.|.:|:.|| ||..:
  Fly   879 -LEQQLRQQIELN---------GITAKTMHLRGSNDVKN------ESLDLQRDNLAD-FLEQVIG 926

Mouse  1580 -------GRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHP 1637
                   ||   |......::::::...:|:....:|::::|:|:....:.|..:.| :......
  Fly   927 IIDMYGGGR---GTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY-VPIRRFV 987

Mouse  1638 LNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWL 1702
            .:::..:|...|       |:|.|.:.|.|.:    |:....:|..:..|.||.:|   ...||.
  Fly   988 SDISPSRLEYYA-------VIVPIGMFFFMFY----FISLPFREYANGFKQLQTMS---RFTYWF 1038

Mouse  1703 SNFVWDMCNYVVPATLVIIIFIC---FQQKSYV------SSTNLPVLALLLLLYGWSITPLMYPA 1758
            ::|.:||         :|:||:|   |..:|.:      ::..|.|:.|.:..||.|..|::|..
  Fly  1039 AHFTFDM---------LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYAL 1094

Mouse  1759 SFVFKIPST--AYVVLTSVNLFIGINGSVATFVLELFTNN-----KLNDINDILKSVFLIF-PHF 1815
            ...||..||  .|::|.          .:.:.:..|.|::     ||::    .|..||.| |.|
  Fly  1095 GNNFKSISTISTYLLLM----------LIVSAIAPLITSSNAAAMKLHE----TKIAFLCFLPDF 1145

Mouse  1816 CLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLF---AMAVEGVVFFLITVLIQYRF- 1876
            .|         |.......|.|...|..: |...|:.::.|   |.||..:|....|:::::::
  Fly  1146 NL---------NHQFRIINENFITRRHPA-LIKGLISQDTFFAYATAVGVMVMAFFTIVLEHKYL 1200

Mouse  1877 ------------FIRPR-PVKAKLP--PLNDEDEDVRRERQRILD--GGGQND-ILEIKELTKIY 1923
                        |.|.: .....||  |:::.| |..||.:|:.|  ....|| .|.:..|.|.|
  Fly  1201 RRRIHDGIWEWAFQRKKYNSTGTLPSTPISEID-DCAREEKRVTDLIKDPLNDHSLIVHNLRKRY 1264

Mouse  1924 RRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQ 1988
            ..|.  |||.:......||||||||||||||::||:|:..:.|:..|...:....|..:..:..:
  Fly  1265 GDKL--AVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYRE 1327

Mouse  1989 NMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVG-------KVGEWAIRKLGLVKYGEKYASN 2046
            ..|||||:||:.:.:|..:.:.:.|||||:..:...       .|..| :.|:.|.||.:....:
  Fly  1328 YFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRH 1391

Mouse  2047 YSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEA 2111
            ||||.||||..|||:||.|.:|.|||||||:||.:|||||.|......:.|:||||||||:|||.
  Fly  1392 YSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEE 1456

Mouse  2112 LCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGL---AFPGSVLKEK 2173
            ||.|:|||.:|:|:||.::..||..  .|:||.:::.........|....|.   .|||..|:|.
  Fly  1457 LCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRES 1519

Mouse  2174 HRNMLQYQLPSSLSSL--ARIFSILSQ---SKKRLHIEDYSVSQTTLDQVFVNF---AKDQS 2227
            |...|.|.:.:..|.:  :.:|.|..:   .:....:.||||::.||:.:|:.|   ||.||
  Fly  1520 HAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQS 1581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abca1	XP_006537617.1	rim_protein	6..2238	CDD:130324	477/1882 (25%)
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	37/147 (25%)
		CcmA	460..767	CDD:224054	110/355 (31%)
		ABC_subfamily_A	461..679	CDD:213230	82/221 (37%)
		ABC2_membrane_3	<937..1117	CDD:289468	44/213 (21%)
		ABC_subfamily_A	1255..1479	CDD:213230	99/226 (44%)
		drrA	1262..1573	CDD:130256	122/315 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.660