Protein Alignment LYST and BPH1

DIOPT Version :10

• Sequence 1: XP_011542333.1
• Gene: LYST / 1130
• HGNCID: 1968
• Length: 3855
• Species: Homo sapiens
• Sequence 2: NP_009961.2
• Gene: BPH1 / 850398
• SGDID: S000000628
• Length: 2167
• Species: Saccharomyces cerevisiae
• Alignment Length: 2388
• Identity: 510/2388 - (21%)
• Similarity: 897/2388 - (37%)
• Gaps: 730/2388 - (30%)

Human  1832 ALALRVILSLIK---YNQQRVHELENCNGLSMIHQVL----------IKQKCIVGFYILKTLLEG 1883
            |:.:::||:|..   .|:|.:.:|:...  ..|.::|          :.||.::.:||
Yeast   122 AVIVQIILTLSNISLINKQTLGKLKKLR--IRIFEILSNKNDSWKSTLLQKNLIEWYI------- 177

Human  1884 CCGEDIIYMNENGEFKLDVDSNAI-IQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVL-IRAD 1946
                          |.|.||...: :|::.|.:||        |...|:..:|  .|:|. .|:.
Yeast   178 --------------FMLSVDCTPLELQNLYLHKEL--------KFCNGILNSL--TLQVSDPRSQ 218

Human  1947 HHQQMFNIKQLLKAQ-----------------VVHHFLLTCQ--VLQEYKEGQLTPMPREVCRSF 1992
            ::.|..|..:|.:.|                 |..:.::|.:  :..|.||||.       |.|.
Yeast   219 NYLQFENTYKLFQIQKSSRINNSFLFYIEFNSVTSNRIMTIERHIYLEIKEGQF-------CISN 276

Human  1993 VKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSIMYLRH 2057
            ...|..:..: .:.|..|:.|..:|..|            |...:|::||.:..:     :.|..
Yeast   277 DNYIIGLFEN-FEFEAGTLYFIGVLIDH------------NNRITLYVDGSMINQ-----LTLFE 323

Human  2058 SSSGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQSQKLT 2122
            :|....|....|.|:.|...:....::|                            |||:
Yeast   324 NSICQLSTCELGSMICSIKVYRFYLWDG----------------------------LLTE----- 355

Human  2123 GSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGKEDAFISSCE------------------ 2169
                .:|:.||.|...|..|.|||          |:|.|  .:|.|:
Yeast   356 ----FAINILQAIGTNYQYTFSKK----------KEGPE--VLSLCQDFLIAKAHLMARPTTEIS 404

Human  2170 SAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLA 2234
            |.|.:.|:|.:....:.:...|..:|      .|..:........::|...::.|.     .|..
Yeast   405 STKYIDEIELLEMENIIIDVNPNDIL------QDFTESSNFTVKFEESTNSKNIPE-----VGKC 458

Human  2235 SFQRSHS------TIASLGLAFPSQNGSAA-------VGRWPSLVDRNTD--DWEN-------FA 2277
            .|.||.:      :|.|:.|||.:...|.:       |....:|: ||.|  :|..       ||
Yeast   459 YFYRSSNLVSKFVSIDSIRLAFLNMTESGSIDDLFHHVSHLMNLL-RNIDILNWFKKDFGFPLFA 522

Human  2278 YSLGYEPNYNRTASAHSVTEDCLVPICCGLYEL-----------LSGVLLILPDVLLEDVMDKLI 2331
            |:|           ...:|:|...|:....:.|           :|..:::..|. .|::   ::
Yeast   523 YTL-----------KQKITQDLSQPLNIQFFNLFLEFCGWDFNDISKSIILDTDA-YENI---VL 572

Human  2332 QADTLLVLVNHPSPAIQQGVIKLLDAYFARA---------SKEQKDKF----------------- 2370
            ..|  |..:|....::..|.::::...|.:.         ||...:||
Yeast   573 NLD--LWYMNEDQSSLASGGLEIIRFLFFQISSLMEASIYSKFNSNKFNDMNILEKLCLSYQAVT 635

Human  2371 ---LKNRGFSLLANQL-------------------YLH-----------RGTQELLECFIEMFFG 2402
               .:|..|:.|::.|                   :||           |.|:.:|:...::|
Yeast   636 KRENQNSKFNELSSDLISVFVTLLKSNTDKRHLQWFLHLSYYFIKRKDVRSTEIILQAVDQLF-- 698

Human  2403 RHIGLDEEFDLEDVRNMGLFQKWSVIPILGLIETSLYDNILLHNALLLLLQILNSCSKVADMLLD 2467
             ...||:..| |:.:.:.     .:||                  |.|:|.|:       |.:::
Yeast   699 -SFYLDQGSD-ENAKILS-----EIIP------------------LKLILMIM-------DQIVE 731

Human  2468 NGLLYVLCNTVAALNGLEK----NIPMSE--YK--------LLAC--------DIQQLFIAVTIH 2510
            |.    ..|.:..||.|.|    |.|:.:  ||        .:.|        :|..|.:..:|
Yeast   732 NN----ESNPITCLNILFKVVLTNKPLFKQFYKNDGLKLILTMLCKVGKSYREEIISLLLTYSI- 791

Human  2511 ACSSSGSQYFRVIEDLIVMLGYLQNSKNKRTQNMAVALQLRVLQAAMEFIRTTANHDSENLTDSL 2575
            ...::.::.|...||   |:|.:.|.|....:         ::..|:.||..  :..:.|.:||.
Yeast   792 GNYTTANEIFSGAED---MIGGISNDKITAKE---------IIYLAVNFIEW--HVINSNASDSS 842

Human  2576 QSPSAPHHAV--VQKRKSIAGSIPMKGSIIPHLPRHHFGSYGQLPMPFSFGPLNQ--------DS 2630
            ......:|.:  |:..||:: ::|:..|:..  |:..:.....|.:..:   ||:        .|
Yeast   843 SVLDLNNHILRFVEDLKSLS-AVPINESVFD--PKKSYVMVSLLDLSIA---LNESEDISKFKSS 901

Human  2631 SPQFS---PGCTTCVVPPGAG------PRKFPLAQTESLLMKMRSVAND----ELHVMMQRRMSQ 2682
            |...|   .|...|.:...|.      ...|....||..|:..::|.|:    ||..::......
Yeast   902 SKVISELIKGNIMCALTKYAAYDFEVYMSTFFCHSTEYKLVYPKTVMNNSSYLELSFIVTLLPEI 966

Human  2683 ENPSQATETELAQRLQRLTVL------AVNRIIY--QEFNSDIIDILRTPENVTQSKTSVFQ--T 2737
            .|       :|......|.::      .::.::|  ::|..|...|:...:....|.|.:..  .
Yeast   967 LN-------DLVDSNNNLNLMMLKHPYTMSNLLYFLRKFRPDTSQIVMPKDFYFSSYTCLLHCVI 1024

Human  2738 EISEENIHHEQSSVFNPFQKEIFTYLVEGFKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLL 2802
            :|.:.:.:|        |:....:.|::.||:.|.:...|.:.:|   |:|. ||.:.|....|:
Yeast  1025 QIDKSSFYH--------FKNVSKSQLLQDFKICIMNLIYSNTLKQ---IIWE-KEEYEMFSESLM 1077

Human  2803 VH--ILSPAHAAQERKQI-FEIVHEPNHQEILRDCLSPSLQHGAKLVLY--LSELIHNHQGELTE 2862
            .|  :|. ||.|.:.:.: ..::...|.   ||||       |....::  :..:|.|.:.:|.|
Yeast  1078 AHQEVLF-AHGACDNETVGLLLIFFANR---LRDC-------GYNKAVFNCMKVIIKNKERKLKE 1131

Human  2863 -----EELGTAELL--MNALKLCGHKCIPPSASTKADLIKMIKEE-------------------- 2900
                 :....:|:|  ::.:..|.:          ::.:.:|.|:
Yeast  1132 VACFFDPANKSEVLEGLSNILSCNN----------SETMNLITEQYPFFFNNTQQVRFINIVTNI 1186

Human  2901 -------------QKKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKSKDISKIAADITQ-AVSLS 2951
                         |.|.:..|..|..:...|.||.:..:..|.|:.|.|. ||...|:: ..:|.
Yeast  1187 LFKNNNFSPISVRQIKNQVYEWKNARSEYVTQNNKKCLILFRKDNTSLDF-KIKKSISRYTYNLK 1250

Human  2952 QGNERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRL 3016
            ...|...|      .|:.:|:.      ||..|.|...:..:| .....|..|..|..:..:|||
Yeast  1251 TDREENAV------FYRNNLNL------LIFHLKHTLEIQSNP-NSSCKWSSDFAEDFDGMKRRL 1302

Human  3017 QRCYLTIPNKY--LLRDRQKSEDVVK----------PPLSYLFEDKTHSSFSSTVKDKAASESIR 3069
            ...:   ..||  |:.:...::|.:.          ..|||.|.:...:..|..|.|      :.
Yeast  1303 LPAW---EPKYEPLINEEDANQDTITGGNRQRRESGSILSYEFIEHMETLESEPVGD------LN 1358

Human  3070 VNRRCISVAPSRET----------------AGELLLGKCGMYFVED------------------- 3099
            .||:.:.:....::                .|.|:.|...:|||.|
Yeast  1359 ENRKILRLLKDNDSIATIWNCSLIIGLEIKEGILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQE 1423

Human  3100 ---------NASDTVESSSLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAF 3155
                     |..|....|:.   |:...|.|...:|..|.||.:.|||.|:|:......:...:|
Yeast  1424 SRDMTVSLINGPDVKRVSTF---LKHEVFVWKLLDITFVTKRPFLLRDVAIELLFKERVSAFFSF 1485

Human  3156 DNTKVRDDVYH--NILTNNLP----------NLLEYGN-ITA----------------------- 3184
            .|.:|||||..  |.:..:||          .:.:.|| |.|
Yeast  1486 YNKRVRDDVLRVLNKIPKHLPADPIFSSVLQEINDRGNSIVARNGIGKASIASKFTSVFSANNSL 1550

Human  3185 -----LTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLS 3244
                 ::..|..|:|:||.||..:|..||||||||.||||||:::|||.|..|||.:...||:||
Yeast  1551 IDGFEISKKWVRGEISNFYYLLSINILAGRSFNDLTQYPVFPWVIADYESNVLDLENPKTYRDLS 1615

Human  3245 KPIAVQYKEKEDRYVDTYKYLEE-EYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFT 3308
            ||:..|.::::.::::.|:.|.. |....|          |:|||:|||::..|..:|:|:.||.
Yeast  1616 KPMGAQSEKRKLQFIERYEALASLENADSA----------PFHYGTHYSSAMIVSSYLIRLKPFV 1670

Human  3309 KMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGE 3373
            :.||..|..||...||.|.|....|..:|.|:.|||:||.||||:|||||:|...:|||..|:|:
Yeast  1671 ESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDVRELTPEFFFLPEFLINVNSYDFGTDQSGK 1735

Human  3374 RVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYF 3438
            :|:.|.|||||..||::||..:|:||||.|||.::.:||||:|||||||..:|:::|||:..:|.
Yeast  1736 KVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFGYKQKGDIAVKSVNVFNRLSYP 1800

Human  3439 G-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAAVGLLVQF--AFR 3500
            | :::..::|..:|||:..:|..:||||.|:|...|..:  ...|:: :|...|...|..  .|.
Yeast  1801 GAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEK--IACNVQ-QLTTEVWRKVPMKPIFE 1862

Human  3501 ET----REQVKEITY--PSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAIC 3559
            :|    .|:.:.:.|  ..| |:...|.|..:                         |.|.
Yeast  1863 KTIFNLNEKNRSVDYVIHDP-SYFDSLYWRGF-------------------------AFPN---- 1897

Human  3560 GLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTS 3624
                     :.:..|:.:.|:......|..|                   .::..:.:...|:||
Yeast  1898 ---------LFFRTEESLVSLRIVHKNWLKI-------------------GLDIFKKTHMAQITS 1934

Human  3625 CA-WVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISV 3688
            .| |  ...:..||.|.|:|..:..|....:.|. .:|.:..::||..|:..:.....|:.|:::
Yeast  1935 FAYW--KLGEFITGDKNGLIKVWKYRKDKHSVSG-NLENKKTMFGHLCELKEMRCYHDYNTLLTL 1996

Human  3689 SRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLV--G 3751
            ...|...:||:.....|:.:.   :....|:.|:.:|.|..:..:    :.:.::.:||.:.  .
Yeast  1997 DISGLVYVWDMINFELVRQIT---NDAQKVAISQHAGSIMVLTKN----NAISIFNLNGQIYTSK 2054

Human  3752 HVHCREIICSV---AFSNQPEGV-------SINVIAGGLENGIVRLW-------STWDLKPVREI 3799
            .....:|:.|:   .|:....|.       .:.::..|.|:|.:.::       :.|.:|.::::
Yeast  2055 KFEPAKIVSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDGTIEIYELFLNFHNEWAIKLLKQL 2119

Human  3800 TFPKSNKPIISL-----TF--------SCDGHHL--YTANSDGTVIAW 3832
            ...| .|.|.|:     |:        :.:.|.:  .....||.:..|
Yeast  2120 CTEK-GKAITSIKGQGKTYLSQKRRKDTAEPHEIEVIAGTLDGRLAIW 2166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LYST	XP_011542333.1	PH_BEACH	3066..3171	CDD:275391	32/150 (21%)
		Beach	3186..3476	CDD:214982	132/291 (45%)
		WD40 repeat	3582..3619	CDD:293791	2/36 (6%)
		WD40	3583..3832	CDD:475233	47/283 (17%)
		WD40 repeat	3623..3668	CDD:293791	12/45 (27%)
		WD40 repeat	3673..3709	CDD:293791	6/35 (17%)
		WD40 repeat	3716..3749	CDD:293791	6/32 (19%)
		WD40 repeat	3759..3800	CDD:293791	8/57 (14%)
BPH1	NP_009961.2	PH_BEACH	1371..1500	CDD:275391	29/131 (22%)
		Beach	1558..1839	CDD:214982	132/290 (46%)
		WD40 repeat	1933..1976	CDD:293791	12/45 (27%)
		WD40 repeat	1981..2017	CDD:293791	6/35 (17%)
		WD40 repeat	2021..2055	CDD:293791	6/37 (16%)