Protein Alignment LYST and lvs1

DIOPT Version :10

• Sequence 1: XP_011542333.1
• Gene: LYST / 1130
• HGNCID: 1968
• Length: 3855
• Species: Homo sapiens
• Sequence 2: NP_595759.2
• Gene: lvs1 / 2540571
• PomBaseID: SPBC28E12.06C
• Length: 2609
• Species: Schizosaccharomyces pombe
• Alignment Length: 2972
• Identity: 655/2972 - (22%)
• Similarity: 1066/2972 - (35%)
• Gaps: 924/2972 - (31%)

Human  1235 QDD------GVDLKSETEGFSASSSPNDLLENL------TQGEII-------YPE---------I 1271
            |||      .:...|:|:....::|||:.|::.      :|.|.:       |.|         |
pombe   123 QDDSNISIYAIGTSSKTDSSIQAASPNEDLKSEGAQEIDSQSETVSISSDVDYDEDRKDLKKAKI 187

Human  1272 C---MLELNLLSA--SKAKLDVLAHVFESFLKIIRQKEKN-----------VFLLMQQGTVKNLL 1320
            |   .|:..||.|  |.|:.|   ..| |.||::...:.|           |...:|:.::|.|
pombe   188 CSAYYLKTRLLLAVLSFAQND---STF-SLLKLVPSLQDNTNASLVELSRVVEAAIQKLSIKPL- 247

Human  1321 GGFLSILTQDDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTKILLLGILKIIES 1385
             .|.::|.|               ::.|..|.:....:.|.||..:..||...|      ||..|
pombe   248 -AFPNVLPQ---------------VLLLCPSISIFNLILLHLRALIRSSPENAI------KIGYS 290

Human  1386 DTTMSPSQYL-----TFPL------------LHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSR 1433
            .|......||     :|||            ||....          |:.|:....:||  ...:
pombe   291 KTMHFLLTYLFEPPTSFPLSDVSKDLLNEITLHCATF----------GVSNASTAKVLR--TYLK 343

Human  1434 SKKEADR----ESFPHRLLSSWHIAP-----------VHLPLLGQNCWPHLSEGFSVSLWFNVEC 1483
            :|.|..|    ::..|.:..|::..|           :..|::..|       |:|||||.|:|
pombe   344 TKSEFLRTWLLKALSHLVAPSFYFNPSTKGYSSIDFTLSSPVMPIN-------GYSVSLWLNIE- 400

Human  1484 IHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGERLIEEGCIHIISLGSKALM 1548
                               ||:..|.::..|                     .:.:||...|:.:
pombe   401 -------------------SLMNDDGNYAPT---------------------TLFLISDFLKSTL 425

Human  1549 IQVWADPHNATLIFRVCMDSNDDMKAV--------LLAQVESQENIFLPSKWQHLVLTYLQQ--- 1602
            .::..|....|::  |.:.|:.|...|        ..:::........|..|..:.|.:..:
pombe   426 FRLLLDASKKTVV--VHIGSSKDTCVVNFSTPITNFFSKIYKDNPSLNPPSWHLITLVHRNEKSS 488

Human  1603 -PQGKRRIHGKI----------------SIWVS-----GQRK--------PDVT-LDFMLPRKTS 1636
             |..:..|.|..                .::||     |.|.        |:|. .|.::...|.
pombe   489 LPNLELYIDGSAVERAACPYPFLSSTLQPLYVSLGPSIGSRNQSTPSTLAPNVAETDALVSENTG 553

Human  1637 LSSD-SNKTFCMIGHCLSSQEEFLQLAGKWDL--GNLLLFNGAKVGSQEAFYLYACGPNHTSVMP 1698
            .:|. ::|::        ...:.|::.....|  |....|....|.||.|. :.:.||:::.
pombe   554 AASQKTSKSY--------KTNDSLKVPPLVPLLIGTTRFFPVPLVSSQIAI-ISSLGPSYSG--- 606

Human  1699 CKYGKPVNDYSKYINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQY---------- 1753
            |..| |:|||..|.....|..| |::.....:|:...:...|.|.:....|...|
pombe   607 CFQG-PINDYMTYKASTALTLE-IQDSKSNTEDLLHSIQAFSRSPIAFMSCARDYVDIMDLQLSD 669

Human  1754 ----TIYEPVIRLKGQMKTQL--------SQRPFSSKE----VQSILLEPHHLKNLQPTEYKTIQ 1802
                ::.|.:.:|:.|..:.:        ..:.||:::    |.|        .::.|...::|.
pombe   670 FCSFSVLETLKKLENQYYSHVYINRAVSSYDKAFSAEQPSFGVSS--------GSVTPIIMQSIS 726

Human  1803 GILHEIGGTGIFVFLFARVVELSSCEETQA---LALRVILSLIKYNQQRVHELENCNGLSMIHQV 1864
            ..::.|||:.|       ::||....||:|   ..|:|..|.|:.|.:....:|..:...::.|:
pombe   727 DAIYNIGGSSI-------LLELVGTAETEAELNFGLQVFFSSIEDNWRFSENVEQTHSFEILAQI 784

Human  1865 L-IKQKCIVGFYILK--TLLEGCCGEDIIYMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSK 1926
            | .|...:|....||  .|:.|.         .:..||     :.::.:..|...|:||:.:|||
pombe   785 LHSKSHLLVSEETLKIIALMSGV---------HHTRFK-----HPLVMNPLLFRYLILDFDLWSK 835

Human  1927 A-EQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQLTPMPREVCR 1990
            | ...::...|..:..||..:.:.. ||:|:|:|.|::...|...:....:|:  |.|
pombe   836 APNSNLFVQQLGYIVSLIENNDYAG-FNVKRLMKMQILKKLLTAMRNCLFHKD--LLP------- 890

Human  1991 SFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHN----PTNFYFSLHIDGKIFQEKVRS 2051
                             :|.::|..|:     |:.:|..|    .|...::....||  .:.:|
pombe   891 -----------------ILRLLFKVLM-----TSAFVSENIRSVATYIIYASQATGK--SKPIR- 930

Human  2052 IMYLRHSSSGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAF--PTSSL 2114
                |.|.|.........::.|..||:.            |.::....:::|...|:|  ..||:
pombe   931 ----RSSVSIAVDRSDSNYISIKESGYA------------ICEEFIDLLIKSNGEPSFLRRFSSM 979

Human  2115 LTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQN--SLGSSDTLK-KGKEDAFISSCESAKTVCE 2176
            :|.:..|      .:.|.|:|.......:...|:  |||||...| ..|...|:...::.|....
pombe   980 ITPAWLL------FLLRQQDIHYFICGIRLLNQSICSLGSSFLSKFSQKFHGFLILHDNLKDHIH 1038

Human  2177 MEAV------LSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDS--PGDESCPRRPDYLKGL 2233
            :|.:      ||..:.:..|.     |.......::|....::|.|:  |..|..|..      .
pombe  1039 LEELWLNLLFLSLGLGIRSVQ-----FRTDLTYKQKLDFVLKNELDNILPLSEVFPSL------F 1092

Human  2234 ASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNTDDWENF------AYSLGYEPNYNRTASA 2292
            .:.|.:...::::.....|:|.:|.         |..||..:|      .||.....||:
pombe  1093 HAIQATLEKVSNVNGKLNSENVAAL---------RYADDTMSFLVTLQTTYSFELTLNYD----- 1143

Human  2293 HSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLVNHPSPAIQQGVIKLLDA 2357
                          ..|||:.|  :.|.:...|.:....:...||..:..|.|....      ..
pombe  1144 --------------FSELLTKV--VFPFLSPVDTITAEQEMRDLLHNIRQPLPRSSS------SK 1186

Human  2358 YFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRHIGLDEEFDLEDVRNMGLF 2422
            .|....|:...||..:..|..:...|    |||          ..:.|..|...|:|:..:....
pombe  1187 TFGEGIKKSVRKFSMSGSFKRVVTPL----GTQ----------LRKDILNDSITDMENTSSFTAS 1237

Human  2423 QKWSVIPILGLIETSL--YDNILLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVAALNGLE 2485
            ...|        :.:|  :||..:..|            :..|::  .|||
pombe  1238 FPQS--------DQALQYFDNFTVQYA------------EAKDVI--KGLL-------------- 1266

Human  2486 KNIPMSEYKLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVMLGYLQNSKNKRTQNMAVALQL 2550
                   :.:|.|    ::..:|    |..|..|.|       :|.||..|:.::.......
pombe  1267 -------FSILTC----IYNRIT----SGQGFSYSR-------LLVYLPPSQIEKKSTFFSG--- 1306

Human  2551 RVLQAAMEFIRTTANHDSENLTDSLQSPSAPHHAVVQKRKSIAGSIPMKGSIIPHLPRHHFGSY- 2614
             :|::.|..:.....:|...|.:                .||..:|   ..|.....|.|...|
pombe  1307 -ILRSTMSKLIEAVKNDKLLLAE----------------PSILANI---SYIFTKFIRMHLLGYL 1351

Human  2615 --GQLPMPFSFGPLNQD--SSPQFSPGCTTCVVPPGAGPRKFPLAQTESLLMKMRSVANDELHVM 2675
              ..|.:....|.|.::  |.|.|.              .|.| ....:..|.|.|...|
pombe  1352 KGSWLEIVDDLGSLLEEIISRPDFL--------------AKLP-KNGRNAAMNMYSCFLD----- 1396

Human  2676 MQRRMSQENPSQATETELAQRLQRLTVLAVNRIIYQEFNSDIIDILRTPENVTQSKTSVFQTEIS 2740
                                    |.:|.|:.:...|.|:....|::
pombe  1397 ------------------------LFLLEVSDLKQTECNAQSDKIIK------------------ 1419

Human  2741 EENIHHEQSSVFN--PFQKEIFTYLVEGFKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLLV 2803
              :|.:.||.:||  .:||::|:.|  .:.|.|.....:|..:......|           |||
pombe  1420 --SITYWQSLLFNSKTYQKDLFSLL--WYAVYIMVETTTGVVRLQAVDAW-----------RLL- 1468

Human  2804 HILSPAHAAQERKQIFEIVHEPNH-QEILRDCLSPSLQHGAKLVLYLSELIHNHQGELT---EEE 2864
                             .:|.|.: .:|.:.|     .:..:....:.:.:.|...:..   ::.
pombe  1469 -----------------FLHSPGYLSDIAKTC-----NNDPRFAYEICKTLDNDSDKFVRWLDDN 1511

Human  2865 LGTAELLMNALKLC--------GHKCIPPSASTKADLIKMIKEEQKKYETEEGVNKAAWQKTVNN 2921
            .......|.:...|        .||.    |..:|.|:        ::...|.:.|...|.|.|.
pombe  1512 AAEVNQFMLSCFFCRWEDFLKQQHKL----ADEEASLL--------QFSRLEHLRKQLAQNTFNE 1564

Human  2922 N------------QQSLFQRLDSKSKDISKIAAD---ITQAVSLSQGNERKKVIQHIRGMYKVDL 2971
            |            ..|||....::.|.:|:..:|   ...|..|||.||
pombe  1565 NILNESSASYHVWISSLFALECNRFKKMSQDQSDQENFVAAALLSQKNE---------------- 1613

Human  2972 SASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYL---TIPNKYLLRD-- 3031
                        |:|:.::....   .|||:||.|||..|.|:||..|.|   .:.:|...|.
pombe  1614 ------------LSHENSILGSK---TTSWELDSTEGSERMRKRLMPCLLQSSELDSKLEARSSG 1663

Human  3032 --RQKSEDV-VKPPLSYLFEDKTHS-----SFSSTVKDKAASES-------------------IR 3069
              |.:|.|. |:.|:|...|:|..:     |...|:.|.|.|:|                   .|
pombe  1664 ARRNRSFDTSVEAPVSLTNEEKQAATLILPSQEETLHDAARSDSNNSMEDEEDDVDEEDKEDKNR 1728

Human  3070 VNRRCISVAPS-------------RETAGELLLGKCGMYFVE------DNASDTVESSSLQGELE 3115
            ...|.|....|             ..|.|.|||||..:|.::      ||....|..:|:..|.:
pombe  1729 TVMRSIESGDSIQDVYNVSRIFGLEATEGILLLGKQYLYLMDNFFLRSDNEIVDVNDNSIIDERD 1793

Human  3116 P-----------------------ASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDN 3157
            |                       .::.|.:.::..|.||::.|||..:|:|..:||:.|....|
pombe  1794 PYLQLLHLQSLSSSGKVRRHISKENNWHWDFIDLSLVLKRFYLLRDVGLELFFKDGRSFLTILSN 1858

Human  3158 TKVRDDVYH--------------------------------NILTNNLPNLLEYGNITALTNLWY 3190
            ||.||.:|.                                |.|::.|.|.|.:......|..|.
pombe  1859 TKNRDSLYQKLVARAPGADVLSTSHFATSMSRDLGKANGKSNFLSSKLANALSFSTTHPATKRWE 1923

Human  3191 TGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQYKEKE 3255
            ..:|:||.||..:|..|||::|||.||||||:::|||.|:.||||:...|||..||:..|:.|:|
pombe  1924 RREISNFNYLQIVNTLAGRTYNDLTQYPVFPWVIADYTSKELDLNNPKTYRNFCKPMGAQHPERE 1988

Human  3256 DRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFD 3320
            .::.:.|..|     .|..:...    ||:|||:|||::..|..:|:|:.||...:||.|...||
pombe  1989 SQFNERYDLL-----LGLNDSQQ----QPFHYGTHYSSAMIVCSYLIRLRPFVDSYLALQGGQFD 2044

Human  3321 IPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQ-NGERVNHVNLPPWA 3384
            ..||.|:|....||.||.|:|.||:|||||||||.|..:|..|||||.|| ....:|.|.|||||
pombe  2045 HADRLFYSIEQAWRSSSKENMADVRELIPEFFYLSEMFINGNGFDFGSRQKESTPINDVILPPWA 2109

Human  3385 RNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFG-MDVSAVEDP 3448
            :.||.:|:..:|:||||.|||.::.:|||||||.||:|..:|.|.||||..:|.| :|:..:|:.
pombe  2110 KGDPAIFVQKNREALESKYVSAHLHEWIDLVFGCKQRGDEAVAATNVFHHLSYQGAIDLENIENE 2174

Human  3449 VQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLN-------IEGELPAAVGLLVQFAFRETREQV 3506
            .:..|...:|..:||||:|:|...|..| |....       :.|....::.||.|
pombe  2175 FELAAAVGIIHNFGQTPKQVFKKPHPQR-GPDFTDTPLGPYLFGRFEDSIHLLFQ---------- 2228

Human  3507 KEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTY 3571
                                   ..:|:..:|....|      :|..|::
pombe  2229 -----------------------SCSPIIRICKKVAH------IQYDPSK--------------- 2249

Human  3572 SKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQ-SEPPVNF--IQSSQQYQVTSCAWVPDSCQ 3633
             .|.|..:.:.|.:..:..|:||..||.::|.|.| .:.||.|  :.|.:...|.:|    |...
pombe  2250 -DEVGAFAADYTPLGPNTFLAWGRVDNTVQLISDQLDKQPVMFEELHSEKITHVVAC----DERT 2309

Human  3634 LFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWD 3698
            ..|.|    :......:|.||...|:...:..||||...||.:.|||.:||::|....|..||||
pombe  2310 FLTAS----LDLTLRLWTLSTNKPIKASLKRVLYGHRYRITCVTVCKAFSIIVSGDAGGNLIIWD 2370

Human  3699 LNRLCYVQSLAGHKSPVTAVSASETSGDIA-----TVCDSAGGGSDL------RLWTVNGDLVGH 3752
            |||..:|.||:.:|.|:..::.:..:.:||     ..|.....|..|      |::..|.|
pombe  2371 LNRAEFVSSLSVYKLPIQTIAVNARNAEIAFSTGFYCCVVNVNGKILVKDKLSRIYNENSD---- 2431

Human  3753 VHCREIICSVAFSN-QPEGVSINVIAGGLENGIVRLWS-------------------TWDLKPVR 3797
               ..|:||..::. ..|.:..|:...|..:||:|:|.                   .|....:|
pombe  2432 ---ENILCSCFYTGANSEWLHKNLFITGHPDGIIRIWEKRLQSNAKLEAEKNNADRPKWRFHLLR 2493

Human  3798 EITFPK--------SNKPIISLTFSCDGHHLYTANSDGTVIAWCRKD 3836
            ::...|        :.:.||::|.:.....::..:..|.|.:|...|
pombe  2494 QLQHTKGLGRNRVATRQNIITITPNGQARGIFAGDDKGQVFSWMLPD 2540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LYST	XP_011542333.1	PH_BEACH	3066..3171	CDD:275391	39/197 (20%)
		Beach	3186..3476	CDD:214982	134/291 (46%)
		WD40 repeat	3582..3619	CDD:293791	13/39 (33%)
		WD40	3583..3832	CDD:475233	73/290 (25%)
		WD40 repeat	3623..3668	CDD:293791	9/44 (20%)
		WD40 repeat	3673..3709	CDD:293791	18/35 (51%)
		WD40 repeat	3716..3749	CDD:293791	7/43 (16%)
		WD40 repeat	3759..3800	CDD:293791	11/60 (18%)
lvs1	NP_595759.2	Laminin_G_3	380..534	CDD:463865	33/203 (16%)
		DUF4704	715..>882	CDD:464870	45/188 (24%)
		PH_BEACH	1738..1871	CDD:275391	33/132 (25%)
		Beach	1919..2202	CDD:214982	134/291 (46%)
		WD40	2255..>2466	CDD:475233	64/225 (28%)
		WD40 repeat	2255..2294	CDD:293791	12/38 (32%)
		WD40 repeat	2300..2340	CDD:293791	10/47 (21%)
		WD40 repeat	2345..2398	CDD:293791	21/52 (40%)
		WD40 repeat	2406..2435	CDD:293791	6/35 (17%)
		FYVE_like_SF	2556..2600	CDD:277249