DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LYST and lyst-1

DIOPT Version :9

Sequence 1:XP_011542333.1 Gene:LYST / 1130 HGNCID:1968 Length:3855 Species:Homo sapiens
Sequence 2:NP_510030.2 Gene:lyst-1 / 181379 WormBaseID:WBGene00011361 Length:2760 Species:Caenorhabditis elegans


Alignment Length:3383 Identity:636/3383 - (18%)
Similarity:1118/3383 - (33%) Gaps:1156/3383 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   760 HVCSHHNQCLPQDVLQIYVKTL---PILLK--SRVIRDLFLSCNGVSQIIELNCLNGIRSHSLKA 819
            |:.||   .|.::.|:..::|:   ||...  |:.||.:||.                       
 Worm   165 HIASH---VLKENELKQILETVSSSPISFSTTSKTIRHIFLH----------------------- 203

Human   820 FETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPK 884
            :|.|::.|.:                    :::...:::||:....:...............:..
 Worm   204 YEILLLRLLK--------------------TTISSKSNYHHRLVLDECKVGFGMLIDDFNNGFNN 248

Human   885 RRKTVNQDVHINTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESL 949
            ..|:..:...:::..|.|...::.:||.|..|     |..|.|.:     :||           |
 Worm   249 LEKSDVRKECVHSAELLLQCYWMLLSKLALED-----DKIDWSIF-----KPL-----------L 292

Human   950 VLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVCHKLIFMIIQKLFRSHKEEQGKKEG 1014
            .:.|...:......|  |::...::.:..::||        |:   ||||.|..:          
 Worm   293 RIQSSRIISFMIQFW--CKYPTNVTGLHNRKFY--------HE---MIIQFLLST---------- 334

Human  1015 DTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVS 1079
             |:..:::.:|.:.:.:|..:..|.|   |:..:...:|:..|   .:.||.|::....|.    
 Worm   335 -TASMDSELVNNMLRQQRMAQNGLTS---KTFALHRFIGNDSK---DVTKLILKYSDFHNF---- 388

Human  1080 ATEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFE-MR 1143
                 |...::|...|..|:.:.|.|                           ||||.  || |.
 Worm   389 -----PSSTRIFDYSEKSTTDELIPL---------------------------LSVEQ--FESMW 419

Human  1144 DHL---SQSKVIETQLAKPLFDALLRVALGNYSADFEHN--DAMTEKSHQSAEELSSQPGDFSEE 1203
            |.:   :|:|.|         :...|:.|....||.||:  ..:...::.|.:.|...|      
 Worm   420 DDITACAQTKNI---------NVTDRIMLRAVIADMEHSVMSRLKRLTYLSKQHLVDHP------ 469

Human  1204 AEDSQCCSFKLLVEEEGYEADSE-------SNPEDGETQDDGVD----LKSETEGFSASSSP--- 1254
                 |.:|        |.|.:|       .|....|..::|:.    |:|:|.....:.||   
 Worm   470 -----CYAF--------YSALAEIIQKRNNRNIFSKEMCNEGLKLVSFLQSQTFNRFVNLSPHEA 521

Human  1255 -------------NDLLENLTQG-EII---YPEICM---LELNLLSASK-----AKLD---VLAH 1291
                         |..|:|.|.. ||:   :...|:   |||....|.|     .||:   .|.|
 Worm   522 EACFKQTLELLIDNPELKNSTMPYEILSACFQNACLQRNLELRNYMAEKIVFVFQKLNNYHALNH 586

Human  1292 VFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRV-----LVDLLVS---- 1347
            ......|::|.:.....|.........|:||..|:|     |...||.:     .:|:|.|    
 Worm   587 FLMLIAKVLRSQSSEDLLRKCYHKKDVLIGGIKSLL-----DSIECQMIDYTYHELDMLDSHFQT 646

Human  1348 ------------LMSSRTCSEELTLLLRIFLEK----SPCTKILLLGILKIIESDTTMSPSQ--- 1393
                        :....||...||     |.::    :| :|:....:.:|:|::||....:   
 Worm   647 DWNNLNCIQDHFIQCHLTCLSILT-----FCDQMHAYAP-SKMWFESVSRILENNTTSGEGEKNT 705

Human  1394 --YLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLR-------RARVSRSKKEADRESFPHRLLS 1449
              ||.  ||:...|:|   |..:| :.|.:.:..:|       ...:...|::|...:|..:.:.
 Worm   706 KMYLN--LLYKQVLTN---STNFP-LPNGELLETIRDKTPLLFLLSIKEQKRDALVANFGKKDIQ 764

Human  1450 SWHIAPVHLPLLGQNC----WPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSS 1510
            .         ||.||.    |..     |:..::.||.::   :.||.|                
 Worm   765 G---------LLDQNTAVLQWSD-----SIISFYLVERLN---NITESG---------------- 796

Human  1511 FDGTESDRPEGAEYINPGERLIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAV 1575
                                                     |...|.|.   ||..:.|.     
 Worm   797 -----------------------------------------WLMAHLAN---RVLKNYNS----- 812

Human  1576 LLAQVESQENIFLPS----KW----QHLVLTYLQQPQGKRRIHGKISIWVSGQRKPDVTLDFMLP 1632
              :||:....::|.|    .|    ||..:.|:..              |:...|.::.:.|...
 Worm   813 --SQVQHDYTLYLRSLLSLSWTYPVQHEDMEYITH--------------VAESPKLNINVYFQFK 861

Human  1633 -RKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLF-----NGAKVGSQEAFYLYACGP 1691
             |||  ..:|......||:.:.....|.:       .|.|:.     ||.||.|    ||.....
 Worm   862 MRKT--GEESEMVSITIGNLVLDMNCFCE-------ANRLICLYTTNNGDKVIS----YLEPTYR 913

Human  1692 NHTSVMP-CKYGKPVNDYS-----KYINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCP 1750
            .|..:|. .:.|:.::.|:     :.:|:.  ....|.|:     .:.|..|..::.:|:.....
 Worm   914 VHKFMMQVSQNGEEISIYTSRKTHRLVNRR--NSHSIDEI-----KISINSLHHTIPIVFQGDRQ 971

Human  1751 AQYTIYEPVIRLKGQMKTQLSQRPF--SSK--------EVQSILLEPHHLKNLQPTEYKTIQGIL 1805
            :.|.::|..|..|...||    |.|  |:|        ...|::...|:.:....:|.......:
 Worm   972 SLYDVHELGISSKNLEKT----RKFVLSTKGRKLNIGQMFHSVIPIRHNQQLSVKSEEAGFTSTV 1032

Human  1806 HEIGGTGIFVFLFARVVEL-----SSCEETQALALRVILSLI--------KYNQQRVHELENCNG 1857
            .::...|.|.|:|....:|     :.|.........:||:.:        |::....|:      
 Worm  1033 EQLRAAGGFGFIFHNFTKLLLEKNADCPVGTVTHWNLILAYLNSPCLKREKFSTSEAHQ------ 1091

Human  1858 LSMIHQVLIKQKCIVGFYILKTLLEGCCGEDIIYMNENGEFKLDVDSNAIIQDVKLLEELLLDWK 1922
              |:..:....|..|...|:|.|.:.|       |..|.|          |::..||.|||.:..
 Worm  1092 --MVSLLFRHTKVKVPESIVKKLFDKC-------MITNHE----------IKEASLLTELLSESS 1137

Human  1923 IWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQLTPMPRE 1987
            :|.|       .|.....:|||........|:.:.|.        |..|::              
 Worm  1138 LWEK-------DLTMFYRLLIRFKSSNPGPNLDKFLP--------LILQIV-------------- 1173

Human  1988 VCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSI 2052
                 .|||....||....:::||..                             :||:|..|. 
 Worm  1174 -----AKIIRNDKGSDEVHDIVTITV-----------------------------EIFKEWCRE- 1203

Human  2053 MYLRHSSSGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQ 2117
                                                         .|.:|:..|..|.....   
 Worm  1204 ---------------------------------------------PHAVRTAQLVTFMMDMF--- 1220

Human  2118 SQKLTGSLGCSIDRLQNIADTY-VATQSKKQNSLGSSDTLKKGKEDAFISSCESAKTVCEMEAVL 2181
                      ..:::..:.:.: ...:...:..|.....|:...:|:     |..:.|....  :
 Worm  1221 ----------DFEKIYPLGENFRWVEEYALERELSRQPILRLNGDDS-----EEEEEVTRRR--I 1268

Human  2182 SAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDD------SPGDESCPR--------RPDYLKG 2232
            :.::...|:|.|                  ..|||      :|.::...|        |...:||
 Worm  1269 NRELLQWDLPLG------------------NVEDDELFRVLTPIEQPTERMLRMMTKNRNYMMKG 1315

Human  2233 LASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNTDDWENFAYSLGYEPNYNRTASAHSVTE 2297
            |  .|..|.                                   ||.|..:..|   |:..|:|.
 Worm  1316 L--LQIIHQ-----------------------------------AYVLCPDTQY---ANFDSITA 1340

Human  2298 DCLVPICCGLYEL-----LSGVLLILPDVLL-----EDVMDKLIQADTLLVLVN--HPSPAIQQG 2350
            :.:    |.|.|:     :.|.|:.:.:.::     .|.:.|::|.:.|.:|..  |..|...|.
 Worm  1341 EKI----CYLIEVNNNGKVVGALIEMYEAIINHNIYSDKITKIVQLNLLPILARQLHSKPLTMQS 1401

Human  2351 VIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLEC-----FIEMFFGRHIGLDEE 2410
            |    :|.|:...:||.|       .|...:..:|...|...:.|     .:.:|         |
 Worm  1402 V----NALFSILLREQVD-------VSAGLDNAHLETFTPNTVSCHAVYPLLSIF---------E 1446

Human  2411 FDLEDVRNMGLFQKWSVIPILGLIETSLYDNILLHNALLL----------LLQILNSCSKVADML 2465
            ...:||.          |.:..::.|||......:|.|..          ::.||...||:.|..
 Worm  1447 ESADDVE----------ISVFTVVCTSLNKVYTFNNQLTQAMTAAGIDEHMVAILAKLSKLGDFR 1501

Human  2466 LDNGLLYVLCNTVAALNGLEKNIPMSEYKLLACDIQQLFIAVTIHACSSSGSQYF-----RVIED 2525
            :.|..|..|.:...|                        .|::|.....:|.|..     |:|..
 Worm  1502 IRNEKLKALLDPWFA------------------------FAISIIRIGVNGRQSVFEGASRLISH 1542

Human  2526 LIVML----GYLQNSKNKRTQ-----NMAVALQLRVLQAAMEFIRTTANHDSENLTDSLQSPSAP 2581
            ::::.    |.|.:.....:|     |:..||.:.:|| ..:|:...|      |.||.:..||.
 Worm  1543 ILLLYTQENGKLLDQPENESQRLIRDNVYWALCVLLLQ-LFKFLLDIA------LADSNKHRSAS 1600

Human  2582 HHAVVQKRKSIAGSIPMKGSIIPHLPRHHFGSYGQLPMPFSFGPLNQDSSPQFSPGCTTCVVPPG 2646
            :.::                        |...|.:.|......|:.                   
 Worm  1601 NSSL------------------------HMLGYDEEPEEIDAAPVK------------------- 1622

Human  2647 AGPRKFPLAQTESLLMKMRSVANDELHVMMQRRMSQENPSQATETELAQRLQRLTVLAVNRIIYQ 2711
              |.||    .:....|::.......:.:::....:...|..|..|:..|::  .||::.:..::
 Worm  1623 --PTKF----WDGFAQKVKESVMGPNNNILKCPYKKHKESPLTAEEMRHRIK--DVLSLCQYFFK 1679

Human  2712 EFNSDIIDILRTPENVTQSKTSVFQTEISEENIHHEQSSVFNPFQKEIFTYLVEGFKVSIGSSKA 2776
            ..|....|                           |:.|::..|.:|:..:.::           
 Worm  1680 ITNRVDCD---------------------------EEDSLYRIFFEELSKWTLD----------- 1706

Human  2777 SGSKQQWTKILWSCKETFRMQ--LGRLLVHILSPAH----------AAQERKQIFEIVHEPNHQE 2829
                :.|...:|...:...:.  ....:..:|:..|          :.|:..::..::|     :
 Worm  1707 ----EAWPNCIWVAADMMFVSNVFANCVTFVLTDIHQYITPYNKVFSRQKSSRMEVLLH-----K 1762

Human  2830 ILRDCLSPSLQHGAKLVLYLSELIHNHQGELTEEELGTAELLMNAL-------------KLCGHK 2881
            |:|.....:...|.  |:.:.::|......:|:.|...:.|...|:             ||..: 
 Worm  1763 IIRSYTKIATVFGN--VMDIDQMIRLAMENITQREDNNSNLFKLAVLFLNCPNGNRSRGKLDDY- 1824

Human  2882 CIPPSASTKADLIKMIKEEQKKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKSKDISKI------ 2940
               |...| .|||       :|...|..:....|              ||.:::.||||      
 Worm  1825 ---PQPRT-PDLI-------QKITVESEIASRYW--------------LDQRNEVISKINLKGRT 1864

Human  2941 ---AADITQAVSLSQGNERKKVIQHIRGMYKV----DLSASRHWQELIQQLTHDRAVWYDPIYYP 2998
               ..|::: ::.|. .:.:|.:...|.|.::    ||.......|.:    ..|.......|:|
 Worm  1865 PQPYCDVSE-INFSL-EKLQKSLAAPRNMKRINEICDLMGKIEENERV----FSRLAAVKNNYHP 1923

Human  2999 TSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHS-----SFSST 3058
            .  ::..|.||..||.......:...:.:::.:..|...:    .|.:|:....|     |..:|
 Worm  1924 R--KITSTLGPRGERMVTDLTDVRTKDMFVMHEHTKKISI----FSEMFDALNFSLIRKPSIFAT 1982

Human  3059 VKDKA-----------ASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQG 3112
            :::..           .:....|:|..|:..|.            |.:.||.             
 Worm  1983 LRNACLHGILIMNGIQTNPVFHVHRTGITALPH------------GSHIVEK------------- 2022

Human  3113 ELEPASFSWTYEEIKEVHK---RWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLP 3174
                   ::.:|.:..:.:   |.|...:.:.||.::|..|||: |...:     :..:::....
 Worm  2023 -------TFLFENMSMIFRRPMRPWDALEVSFEILMSNHETLLI-FSQQR-----FSKLVSQYAT 2074

Human  3175 NLL--EYGNITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDL 3237
            .|:  |: .:.|.|..|..|:::||||||.||..|||:.:|....|:||.|||.:..:::||.|.
 Worm  2075 KLIATEH-QLLAYTKRWEEGKMSNFEYLTMLNLFAGRTIHDSSSSPIFPRILAKFGDKSVDLQDK 2138

Human  3238 LIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLV 3302
            .|||.|.:|:|.|.....:::.:.|..|        :|::.:..:.|||:||..||.|.|..|.:
 Worm  2139 TIYRKLDRPVAAQDPVSVEKHKEHYNEL--------KENEEISHLTPYHFGSMCSNRGVVSFFNI 2195

Human  3303 RMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFG 3367
            |:.||.:..:..||..||.|||.||:..:...|...||..|.|||:||.|...|.|.|..|..||
 Worm  2196 RLLPFGEEAIELQDGRFDFPDRLFHNIESGLGLGKIESSNDYKELVPELFTTVEVLRNDNGNQFG 2260

Human  3368 VRQNGERVNHVNLPPWARNDPRL----FILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQA 3428
            .:||||.||.|::|.|...|.:.    ||.:||.||||:.|...:..|||||||||.:||::..|
 Worm  2261 EKQNGETVNDVDVPQWCYMDEKAVHENFIYLHRHALESEIVQSMLHHWIDLVFGYKSRGKSAHDA 2325

Human  3429 INVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAAVGL 3493
            |||:|||.|.|.......|.|...|.|...||.|..|.|||..:|..|.                
 Worm  2326 INVYHPAVYPGNSPPPSFDRVMTNAYEANQKTLGTAPIQLFTQSHPKRE---------------- 2374

Human  3494 LVQFAFRETREQVKEITYPSPLSWIKGLKWGEY-VGSPSAPVPVVCFSQPHGERFGSLQA-LPTR 3556
                ..:..|..|:.:   ..|::.|.|..|:| ||..:.....   :|....|..:|:: :..:
 Worm  2375 ----VLQHRRSSVRNM---HGLAFGKELTIGQYDVGEYTMDTQT---TQRVWRRMKNLKSKIFNK 2429

Human  3557 AICGLSRNFCLLMTYSKEQGVRSMNSTDIQW-----SAILSWGYADNILRLKSKQSEPPVNFIQS 3616
            |......||.|   :.|.:..|..:.:||.:     ..|||.|.::     .||.....:..:..
 Worm  2430 ANASDQENFHL---FQKNRDKREKDPSDISFKIKEDQLILSDGNSE-----ISKGHAQKIEAVSV 2486

Human  3617 SQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIH---------------- 3665
            ...|.         :|.|..|.    |..|...:...:.|.|.::..:.                
 Worm  2487 DDNYV---------ACMLLRGP----IEIYKMAYRQYSKSRIAVDRVLRSDNKELVIEYCGTLPV 2538

Human  3666 LYGHTEEITSLFVCKPYSILISVSRD---GTCIIWDLNR-----LCYVQSLAGHKSPVTAVSASE 3722
            ..||   .|.:.||..:|.:.::.::   ....:|:|:.     .|.::.:      |.:....:
 Worm  2539 QEGH---YTDVEVCTSFSTIFTIHKNENKSIISVWNLHTHHIRGCCTIEGV------VESCGVLK 2594

Human  3723 TSGDIATVCDSAGGGSDLRL---W------TVNGDLVG---HVHCREIICSVAFSNQP------- 3768
            ..|::  :......|:.:|.   |      |.....||   ..|..:|:..::.:.:|       
 Worm  2595 NLGEL--IVTEKWNGNQIRFIKGWRIKKRETKKNKYVGKFAREHSEQIMAKISINAKPFISKYIG 2657

Human  3769 ---------------EGVSINVIAGGLENGIVRLWSTWDLK-------------PVREITFPKSN 3805
                           .|:.|..:|....:..:.|:.|.:|.             .:||:.|.:.|
 Worm  2658 KNQFVHSGVISMPPEPGMGIQTLAMIRSDHAIVLFETMNLTEMRVLEVENRMDYSLRELRFQEDN 2722

Human  3806 KPI 3808
            ..|
 Worm  2723 SLI 2725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LYSTXP_011542333.1 PH_BEACH 3066..3171 CDD:275391 17/107 (16%)
Beach 3186..3476 CDD:214982 123/293 (42%)
WD40 <3530..3837 CDD:225201 56/356 (16%)
WD40 repeat 3582..3619 CDD:293791 8/41 (20%)
WD40 3583..3832 CDD:295369 47/302 (16%)
WD40 repeat 3623..3668 CDD:293791 7/60 (12%)
WD40 repeat 3673..3709 CDD:293791 7/43 (16%)
WD40 repeat 3716..3749 CDD:293791 5/41 (12%)
WD40 repeat 3759..3800 CDD:293791 9/75 (12%)
lyst-1NP_510030.2 Beach 2087..2373 CDD:214982 123/293 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1786
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.