|
Human 587 DPKSVIIPLLHAFKLPALKNFQQ---------HILNILNKLILDQLGGAEISPKIKKAACNICTV 642
|| |.::||.| |:.::...|| |....|..:::.: :::.|.:..|:
Worm 33 DP-SRLLPLFH--KVMSMYTPQQLNAEFKEVVHFATFLCSVLVKE---------VRQRAASTGTI 85
Human 643 DSDQ------------------------LAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGS 683
::.| |:..:|.:....|...|.|:|....|.|.. ||::.:
Worm 86 EAAQSIAEFLRPGTELKGYTILEAIRFLLSSEDEIMIDAACKVSLPSTLVKTIYLFFD-LPAAAT 149
Human 684 ----EDLLWKWDALKAYQNFVFEEDRLHSI--QIANHIC-------NLIQKGNIVVQ-------- 727
.|| ..:|.:.....:...::||.: ||...:| .|::|.::::.
Worm 150 TVTVTDL--TENATETEDEMLKNNEKLHDMIGQIMEGLCRFKCVSEELVRKDDLLLLFVGTTSQV 212
Human 728 ------W-KLYNYIFNPVLQRGVE-------LAHHC-----QHLSVTSAQSH------------- 760
| ||...:...:..:.:. :...| ::||...:.||
Worm 213 AEANNCWRKLCARLLEVIADKSITNAVIKYVIVKKCVRIFVKNLSSAPSNSHSDAQKTAESIICL 277
Human 761 VCSHHNQCLPQDVL-------QIYVKTLPILLKS----RVIRDLFLSC----------------N 798
.|...|.....|.| ..|......|||| .::|::.|.. :
Worm 278 SCFLKNSAYLTDQLLDEFYEADGYTVIKDFLLKSETDNEIVRNILLMAISLVNSGKFEITPQYTS 342
Human 799 GVSQI----IELNCLNGIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFH 859
|:.|: :.:...||:...:|.||..|.....|...:::...: ||| |.|:
Worm 343 GLVQLPAFQLPIPAGNGLSVRNLNAFALLYHVFLESTSESTSCTV--IDI----LHSI------- 394
Human 860 HQQAYSDSPQSLSKFYAGLKEAYP-------KRRKTVNQDVHINTINLFLCVAFLCVSKEAESDR 917
|:..|.: |..|.:.|| ..||. |...:.|...:.|
Worm 395 ----YTCDPAN----YFILDKEYPLSIFIDQLERKP-----HAVRVKLLELIEF----------- 435
Human 918 ESANDSEDTSGYDSTASEPLSHMLPCISLESL-VLPSPE----HMHQAADIWSMCRWIYMLSSVF 977
|...||| :||..|.|| ||...| .......|..||..:..:.::.
Worm 436 ---------------AVFQLSH-IPCRELISLCVLLKTEISAGKTAMCTIIVQMCFKLITVDAII 484
Human 978 QKQFYRLGGFRVCHKLIFMIIQKLFRSH-KEEQGKKEGDTSV-NENQDLNRISQPKRTMKEDLLS 1040
:..|..:| :...|.| ||:::|..: |..|......||. :.:||..::| .:..|||:
Worm 485 KDAFREVG---LLDALCF-IIRRMFEMYEKNIQNASFTVTSTSSRSQDQLKLS----LLTTDLLT 541
Human 1041 LAIKSDPIPSELGSLKKSADSLG-KLELQHISSINVEEVSA--------TEAAPEE---AKLFTS 1093
:.||:: :|.|.| ..:..| ||.::.:..:|.|..|: ...||.: ..|..:
Worm 542 IIIKNN---TENGKL--FTECFGAKLLIEIVCEVNEEWRSSLLQLVKQLLIVAPTDQYIMHLVNT 601
Human 1094 QESETSLQSIR----LLEALLAIC--LHGARTSQQK-----------MELE-------------L 1128
.:....::::. ||:|||.:. .|..|...:| :.|| :
Worm 602 LQDRIPIENLEVMFSLLKALLGVVRESHKVRIQFRKSGGFLALSALLLGLEKRFTDLHPAGDGRI 666
Human 1129 PN---QNLSVESILFE-----MRDHLSQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEK 1185
|. |.|....|:|: ||...|.:|...|::......:|||: .....|.
Worm 667 PREQCQMLEFVHIIFKVFTLSMRFEPSNAKYFSTEITWDSITSLLRL-----------TSIFNES 720
Human 1186 SHQSAEELSSQPGDFSEEAEDSQCCS--FKLLVEEEGYEADS----------------------- 1225
:..|.||...:....::.|.:...|. |:| ::..||.:
Worm 721 TVISIEETEWKSLTHTDLASEIAACHEVFRL---DDNIEAGNVPKGMPFNIYFGCYVCRLIFNMA 782
Human 1226 ----ESNPEDGETQDDGVDLKSETEGFSASSSPNDLLENLTQGEIIYPEICMLELNLLSASKAKL 1286
|....|....|||..|:.....:::|. |.....|...:|:|. .:|||..|.
Worm 783 LDNYEKMTSDIRWNDDGASLEESIVSWTSSL--------LVHPGAIISMLCLLP--SISASSMKW 837
Human 1287 DVLAHVFES-FLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS 1350
.:.|..:.| .||.|.:.|:|..::.|....|:|
Worm 838 TIAAQYYVSLLLKAILKSERNQQIMCQVDMPKHL------------------------------- 871
Human 1351 SRTCSEELTLLLRIFLEKSPCTKILLLGILKIIE--SDTTMSPSQYLTFPLLHAP---------- 1403
|.:..::||.:: .|||.....::| |..:::|:|..:|..|.:|
Worm 872 -------LRIAEKLFLTEN---HILLQPFYYLLERLSYQSLTPNQLRSFLRLDSPLCCRSLDDDE 926
Human 1404 ------------NLSNGVSSQKYPGILNSKAMGLLRRAR-----VSRSKKEADR--ESFPHRLLS 1449
|....|..|:. ||:..:...| .:.|..|.|. |.|....|.
Worm 927 DDDDDSKIEIADNEGGPVPLQRV------KALVSMMTPRDQYIGTAPSFVEFDMSVEGFAALYLP 985
Human 1450 SWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGT 1514
| :||:......:..:|.|: |||...|..::.:.:.::.... .::....:::..|:|. .
Worm 986 S--LAPMFSTTKAERIFPPLN-GFSFCTWIYLDALSDKKADAHP-IRLLTVTRAVAPPNSD---P 1043
Human 1515 ESDRPEGAEYINPGERLIEEGCIHI-ISLGSKALMIQV-WADPHNATLIFRVCMDSNDDMKAVLL 1577
.|.:|....:: .|... .|...::|:|.. .:|...|.|.......::..::..|.
Worm 1044 PSKKPSQTAHL---------ACFQCQFSAFDRSLLISTEESDQPGADLEKTANFQTDKLIRITLA 1099
Human 1578 AQVESQENIFLPSKWQHLVLTYLQQPQGKRRI--HGKISIWVSGQRKPDVTLDFMLPRKTSLSSD 1640
.||...| |.||.:.: .|.: ..::|::::|:......|.::.......::.
Worm 1100 DQVRCGE-------WFHLAVVF------NRSVLKSSQVSLYLNGRHISTQKLMYVAQNAGGAATQ 1151
Human 1641 SNKTF---CMIGHC------------LSS---QEE---------FLQLAGKWDLGNLLLFNGAKV 1678
..:|: .::|.. |:| .|| .:||...: :||....:.|.:
Worm 1152 LAQTYSVNAVVGTLPALRRPSRLRFRLASIFLAEEPMTAETVRAVVQLQPHY-IGNYQTASTAPL 1215
Human 1679 GSQE--AFYLYACGPNHTSVMPCK--YGKPVNDYSKYINKEILRCEQIRELFMTKKD--VDIGLL 1737
..:| .|.|.|......::...: ||| ::.|||. :.|.::..| ..:.:|
Worm 1216 FHEEKIVFSLSAAATQELTLAKIRTMYGK--------MDAEILS----QHLGISPNDHSTPLRVL 1268
Human 1738 IESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKTIQ 1802
..::| :.|.....:..|| ...|..|.|:.:.|.|
Worm 1269 CNTIS-----HAPGAGRTFGGVI------VGYLGMRTFTPRPVPS-------------------- 1302
Human 1803 GILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIK 1867
:|..|||......|.|..|: .|....:|:.::|.|: :|.|:....|.|....|..||::
Worm 1303 -LLDSIGGFASVYGLIAMAVD----SEGLYASLKSLVSAIR-SQPRLLATWNNNRSYQILAVLLE 1361
Human 1868 QKCIVGFYILKTLLEGCCGEDIIYM--NENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQG 1930
.|. |.| ...|::| |..|......:....|.:....|:||.|.|:|..|...
Worm 1362 DKA-------KML-----NSHIMHMVFNVTGTADTSREHAPTISNPSAFEDLLCDLKVWKGAPSE 1414
Human 1931 VWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQLTPMPREVCRSFVKI 1995
:.:.||.....|| .|| |:.|::.:.|:.::...||.. :.|..:.....|:..:.:..
Worm 1415 LHKMLLEHFYELI-TDH--QLNNLQVVRKSSLLSRILLII-----HDEPTMIKNTDEIIFNLISA 1471
Human 1996 IAEVLGSPPDLELLTII-FNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSIMYLRHSS 2059
|.: |..:..:|: ....:|...||:...|:..::..|.:....|:|.|
Worm 1472 IMQ-----PQCDSRSILKIGQSIAATLPTSESECYEDSHLPFHISEIQKLFIE------------ 1519
Human 2060 SGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQSQKLTGS 2124
||: |...|.|.:..|
Worm 1520 ----------------------------SSD--PPPEALHQVYIR-------------------- 1534
Human 2125 LGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGKEDAFISSCESAKTVCEMEAVLSAQVSVSD 2189
:||.||. .|.|.:|:| ..|..:.|
Worm 1535 -----NRLLNII----------ANFLANSNT--------------------------QVQQQMCD 1558
Human 2190 VPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLASFQRSHSTIASLGLAF---- 2250
.....||| |:|..|.| ...||....|.|..
Worm 1559 QLVRTLGF------------------------------DWLFALMS-PGVHSGTIYLALRILLLI 1592
Human 2251 ---PS-----QNGSAAVGRWPSLVD---RNTDDWENFAYSLGYEPNYNRTASAHSVTEDCLVPI- 2303
|| :.|||. |.|.|..| || ..|..||: :.|||.......:.|
Worm 1593 LNQPSLLARFKEGSAN-GGWLSEADSVVRN-----RAAVVLGF------SVSAHGGAVGSKIDIN 1645
Human 2304 ----CCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLVNHPSPAIQQGVIKLLDAYFARASK 2364
.||.:..|..::....| .|.| |:|.
Worm 1646 PELSNCGGFAALEHLMAAHAD---------------------KPYP------------YYAM--- 1674
Human 2365 EQKDKFLKNRGFSLLANQLYLHRGTQELLEC---FIEMFFGRHIGLDEEFDLEDVRNMGLFQKWS 2426
.|||..| ....|..| .:|:.:....||:....:.:..|...|...:
Worm 1675 -----------LSLLVGQ-----PISALRFCDQFNMELVWTHVFGLNSTSSVFEAINSANFCFDA 1723
Human 2427 VIPILGLIETSLYDNILLHNALLLLLQILNSCSKVADML---------------LDNGLLYVLCN 2476
:||:..:|.||:|....:|.. ..:.:.|.|..|: .|..:|.:...
Worm 1724 IIPLFAMIRTSIYHQSSIHQP-----WTVTNPSTVVQMITFMYQNSPAFFNIAHTDEFILALFST 1783
Human 2477 TVAALN--GLEKNI-----------PMSEYKLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLI- 2527
.:...| |::..: |.:|| .|.|:| ....|::.||:
Worm 1784 LIEDTNAMGVKSEVANRRSQDGGGSPDAEY-------FQAFLA----------QPNVRIVMDLLK 1831
Human 2528 ----------------VMLGYLQN-SKNKRTQNMAVALQLRVLQAAME------FIRTTA---NH 2566
::...|.| |::..|:...:|....:|.:.:| .:.::| |.
Worm 1832 KICCDNLQVNTSKNDTIIDAILDNISESGNTRKTQIACLTSLLHSVLEHTVGTDLLSSSALPPNT 1896
Human 2567 DSENL-------------------------TDSLQSPSAPHHAVVQKRKSIAGSI---PMKGSII 2603
.::|: ::|::..|..:|..|...|.:..:: |:.|.|:
Worm 1897 QAQNIVQIVANISLLSSRAVDAFWNGLVFGSESMRMLSTLYHLQVIASKKVNKAVNAEPITGCIM 1961
Human 2604 PHLPRHHFGSYGQLPMPFSFGPLNQDSSP-QFS--PGCTTCVVPPGAGPRKFPLAQTESL----- 2660
::.:.....|: ||.| |.| ...:|.| ..|...|:..|:.
Worm 1962 ------------RMTLFILSRPI--DSVPVQLSVLDALSTLV-----SKRYLFLSSNEAWFFASL 2007
Human 2661 --LMKMRSVANDELHVMMQRRMSQENPSQA----TETELA-------------------QRLQRL 2700
|:.|.||..| |:.| .|:|.|.: |..::| :..::.
Worm 2008 THLIFMLSVTPD---VLFQ---FQDNSSSSDLDRTSAQVAMCACRVWSDVICAKQALIEETFKKQ 2066
Human 2701 TVLAVNR----------IIYQEFNSDIIDILRTPENVTQSKTSVFQTEISEENIHHEQSSVFNPF 2755
:|..:|. :.:|:|....:..::|..:..|. ::|...:|.::.| ||.||..
Worm 2067 SVTDINAARALLSHSAGVYWQQFVDSQLRAIQTGGSSAQG-SAVTAKDIIQQQI----SSKFNRV 2126
Human 2756 QKEIFTYLVEGFKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLLVHILSPAHAAQERKQIFE 2820
...|..:..:....:..:..:|||...| |...:.|:...|.| |:.|.::.....||..:
Worm 2127 ASGITRFAAKRSMSTTTALPSSGSVAAW-KSTSTDKQVIFMWL-RVHVSLIKELVRAQSTR---- 2185
Human 2821 IVHEPNHQEILRDCLSPSLQHGAKLVLYLSELIHNHQGELTEE------------ELGTAELLMN 2873
:...|..:.:.||.. .|..:.|||.| |....:|...
Worm 2186 --YTEWHAHVRKWCLHD---------------WHQWEAELTRERGIWGPERASKLEKFKLDLTEG 2233
Human 2874 ALKLCGHKCIP----------------PSASTKADLIKMIKEEQKKYETEEGVNKAAWQKTVNNN 2922
.......|.|| |||..:...:.:..:.:..||| .:.:.
Worm 2234 PTTRMRRKLIPNRNFYHIYPFRPHLEAPSAKAQRAKVAISFDSKPYYET-----------CLRHR 2287
Human 2923 QQSLFQRLDSKSKDISKIAADITQAVSLSQGNERKKVIQHIRGMYKVDLSASRHWQELIQQLTHD 2987
::: ||::..|.|.:: ..|...|:....:: |....|||.|.....||::|:..
Worm 2288 RRT----LDTRIIDSSNVS-----TASPEDGSGSSNLL----GYSFTDLSLSEINSSLIRRLSTT 2339
Human 2988 RAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTI-------------------PNKYLLRDRQ 3033
.....: ...||.:|:..|....||:.......:| ..|...::.:
Worm 2340 APATSN--VSGTSLELNEEECETSERKEDDESISSISEKTDSNGVQSSGPSTSSNTTKEAKKEEK 2402
Human 3034 KSEDVVKP---PLSYLFE--DKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCG 3093
|.|....| .|..|.| ::.||.| ||..:.......|.||.|:..
Worm 2403 KEEKKAGPDNQTLLRLLEQGEQLHSMF-----------------RCARIQGLETAEGLLLFGRDH 2450
Human 3094 MY-----------------FVEDNASDTVESSSLQGELEPASFS-----WTYEEIKEVHKRWWQL 3136
.| |:.....|.:......|..:|...| ::|..|:|||||.:.|
Worm 2451 FYVVDGFTLLKTKEIRDLDFLSQEMHDPIVPYPATGATQPPKSSRLCSKFSYNMIREVHKRRYLL 2515
Human 3137 RDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLPNLLEYG---------NIT--------- 3183
:..|:|:|.::||..||||.. |:||.|:.. ||:...||...| |:.
Worm 2516 QPIALEVFSSDGRNYLLAFPK-KIRDRVFDK-LTSMAINLSSGGSDSLGGQKANVAIETTGRGAS 2578
Human 3184 ---------ALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLI 3239
::|..|.:|.|:||:||.|||..|||.:|||.|||:||::||||.|..||.|::..
Worm 2579 LLSSLIGQQSVTQRWLSGNISNFQYLMHLNTLAGRCYNDLSQYPIFPWVLADYTSSQLDFNNIST 2643
Human 3240 YRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGARE-DDPMPPVQPYHYGSHYSNSGTVLHFLVR 3303
:|:.|||:..| ..||. |::.|..|| |||.....||.||:|||::..|:.:|||
Worm 2644 FRDFSKPMGAQ---SPDRL--------EQFLKRFREWDDPSGETPPYMYGTHYSSAMIVVSYLVR 2697
Human 3304 MPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGV 3368
:.|||:.||:.|...||:.||.|||....|..:|..:|.||||||||||.|||...|...||.||
Worm 2698 LEPFTQQFLSLQGGHFDLADRMFHSVGDAWTSASRNNMADVKELIPEFFTLPEMFTNTNHFDLGV 2762
Human 3369 RQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFH 3433
:|||..||.|.||.|...|||.||.:|||||||||||.::.:||||:|||||.|:.:|:..|:||
Worm 2763 KQNGIHVNDVLLPAWCHGDPREFIRLHRQALESDYVSSHLHEWIDLIFGYKQNGEEAVKNSNLFH 2827
Human 3434 PATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAAVGLLVQF 3497
...|.| :|...::||:.|.|....:..:||.|.|||...| |..|:||........|:....
Worm 2828 HLFYEGSVDFERIDDPLTRNATIGFVNNFGQIPTQLFKKPH---PQKKVNILEGFSNTPGVTTSR 2889
Human 3498 AFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGE---RFGSLQALPTRAIC 3559
.|... :.:.||| ..|..| ..||:.......:.
Worm 2890 LFYHA------------------------IHNMSAP------QTPFKELRSAIGSIHQNDKIGVV 2924
Human 3560 GLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTS 3624
.|.:|...:.| :..::||..|..:|:....::..|...:..:..::|
Worm 2925 ALEQNKVFIGT-----------------NRYITWGLPDRSVRMGQIDNDKSVCVHEMCEVDEMT- 2971
Human 3625 CAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVS 3689
||...|...||.|:..|.||.:. .::.| :.|:....|.||::.||.|..|:.:::|:|.|
Worm 2972 CAAAGDETTLFCGNTSGCITVWK---VNNKP--LSMKKLSVLNGHSDAITCLVSCQSHAVLVSAS 3031
Human 3690 RDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVH 3754
||.|.::|.|:.:..::.|..|...|.||:.::.:|||||.|.:. |.:||:||:|:..::
Worm 3032 RDLTVLVWHLSEMFLIRQLPKHPHAVLAVAVNDATGDIATACSTL-----LHVWTLNGELLAVLN 3091
Human 3755 -C--------REIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITF--------- 3801
| :::|.|:|||...|..:.|||..|..:|||:::|. :.|
Worm 3092 TCDVAPAIDPQQMIISLAFSTMNEWDNDNVIMCGTSDGIVKIYSC--------VVFENDGSVSEH 3148
Human 3802 -----PKSNKPIISLTFSCDGHHLYTANSDGTVIAWCRKDQQRLK 3841
|.|| |.:.| :....:.|...|.::|||
Worm 3149 PALENPNSN--------SNENH-----DRSAAIAARLEKQRKRLK 3180
| 
