Protein Alignment LYST and sel-2

DIOPT Version :10

• Sequence 1: XP_011542333.1
• Gene: LYST / 1130
• HGNCID: 1968
• Length: 3855
• Species: Homo sapiens
• Sequence 2: NP_001379017.1
• Gene: sel-2 / 175606
• WormBaseID: WBGene00004760
• Length: 2563
• Species: Caenorhabditis elegans
• Alignment Length: 3127
• Identity: 656/3127 - (20%)
• Similarity: 1123/3127 - (35%)
• Gaps: 964/3127 - (30%)

Human  1008 EQGKKEGDTSVN-ENQDLNRISQPKRTMKEDLLSLAIKSDPI------------PSELGSLKKSA 1059
            |:|::..|...| |..||.         .:|  |.|..|.|.            ||:  :.||..
 Worm    26 EEGEEVNDEESNMETVDLG---------LDD--SAADASSPSVFKNIDDEAPGDPSD--AAKKEE 77

Human  1060 DSLGKLELQHISSINVEEVSA----TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTS 1120
            ||         ..|.|..|.|    .|.:|..|                 :|:|..:
 Worm    78 DS---------EEIVVPSVLAPTPSQEVSPPNA-----------------IESLPPL-------- 108

Human  1121 QQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDAL----LRVALGNYSADFEHNDA 1181
            .:..||||..:.|:......|.  .|:|.....||..:..:.|.    .|.:|.::|..|.
 Worm   109 PEGKELELEPEELTPAQFFIEY--DLTQPSTPGTQSRRDSYSATGNISRRGSLASFSKSFN---- 167

Human  1182 MTEKSHQSAEELSSQPGDFSEEAEDS--QCCSFKLLV--EEEGYEADSESNPEDGETQDDGVDLK 1242
                        .|.|  ||::...|  :..|...|:  .|||  ||        ||....|.:.
 Worm   168 ------------ISIP--FSDDVTSSLPRLLSKTTLIHSNEEG--AD--------ETIQRLVTVL 208

Human  1243 SETEGFSASSSPN-------DLLENLTQG-------EIIYPEICMLELNLLSASKAKLDVLAHVF 1293
            .       |:|||       |.|.||..|       :.:..:...::..|...|....|:...::
 Worm   209 H-------SNSPNTDRTQVVDNLFNLLVGGHFDQESKFVIEDAANVDHMLTLLSHCDYDLQNEIW 266

Human  1294 ESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMSSRTC---- 1354
            ..||.::::..:|    ::..|...|:...|.||.:       ...:|.||||.::::...
 Worm   267 SLFLAVMKKSNRN----LEACTRVGLISKVLDILPE-------APPLLADLLVQIIAALVAYSIN 320

Human  1355 ---SEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPG 1416
               ::.|...|:...|:.|...:.||.:||  |.....|...:.:||            .:...|
 Worm   321 VKQTKHLLRALKSTKEQWPPNSLKLLHVLK--EMPQHDSADVFFSFP------------GKDQSG 371

Human  1417 ILNSKAMGLLRRARVSRSKKEADRESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNV 1481
            |:                                  :.|:       ...|: .:|::.:.|..:
 Worm   372 II----------------------------------LPPI-------KTMPY-QQGWTFATWLRM 394

Human  1482 ECIHEAESTTEKGKKIKKRNKSLILPDSSFDG----TESDRPEGAEYINPGERLIEEGCIHIISL 1542
            |.::......|:......|....:.....|.|    ...::.:|.|         :..|:. ..|
 Worm   395 EPLNSVTFEKEQPVLYSFRTSKGVGYSCHFTGNCLVVNVEKTKGKE---------QSRCVR-AEL 449

Human  1543 GSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKR 1607
            |::                                             ||.|:.:.:.....|:
 Worm   450 GAR---------------------------------------------KWHHIAIAHCYSRWGR- 468

Human  1608 RIHGKISIWVSGQRKPDVTLDFMLPRKTS-------LSSD--SNKTFCMIGHCLSSQEEFLQLAG 1663
               ..|..::.||....:.|.:::...|:       :|:|  :|..||
 Worm   469 ---SDIKCFIDGQLAETIELSWVVTSATNWDRCSIGVSADGTANSAFC----------------- 513

Human  1664 KWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSKYINKEILRCEQIRELFMT 1728
             ..:|.:.||..| :..|:|..|:..||.:.|..  |:....:....|
 Worm   514 -GQMGAMYLFAEA-LTLQQANSLFCLGPVYQSTF--KHDSETSLPEGY----------------- 557

Human  1729 KKDVDIGLLIESLSVVYTTYCP----AQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHH 1789
            ||.:..|.|..||  |: .|||    .|..:|.|.   |....|...|.|.:..:....::..|.
 Worm   558 KKHLFDGHLHSSL--VF-AYCPKNCHGQLCLYTPP---KTAASTYFVQIPHAVMKEGVEVITTHS 616

Human  1790 LKNLQPTEYKTIQGILHEIGGTGIFVFLFARVVELSSC-------EETQALALRVILSLIKYNQQ 1847
            :       :|::|    .:||..|.:.|||: ::|.|.       |..|.| |.:|..|:..:|.
 Worm   617 I-------HKSLQ----SVGGIQILLPLFAQ-IDLPSSNDNSIDGEVCQTL-LSLIALLLSSSQS 668

Human  1848 RVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDIIYMNENGEFKLDVDSNAIIQDVK 1912
            ...:|.:..|..:|...|  ||.......:|.|      |.:|::   .:|.|...:...:.. .
 Worm   669 SQQQLFHSKGFLIISSCL--QKASPSHLSMKVL------EQLIHI---AKFLLRCPAGGPLLK-H 721

Human  1913 LLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLK--------AQVVHHF--L 1967
            |.:.:|.:.|:|.:|...|...|...|.....|::     |..|:|:        ...:.||  |
 Worm   722 LFDYILFNPKLWIRARPEVQVHLYQYLATDFLANN-----NFSQMLRRVPTVIEMCHTLKHFYWL 781

Human  1968 LTCQVLQEYKEGQLTPMP-----------REVCRSFVKIIAEVLGSPP------DLELLTIIFNF 2015
            ...|.:.:|   .:...|           |....:|:..|......|.      |.|:.|:: |.
 Worm   782 ALPQTVSDY---TIEERPENFATADIVAIRSSILTFINRIIIASAGPEEEERVRDQEVHTLL-NL 842

Human  2016 LLAVHPPTNTY---------VCHNPTNFYFSLHIDGKIFQEKVRSIMYLRHSSSGGRSLMSPGFM 2071
            |..|....|.|         :..:|     ::.|.. |.:.|...|::        ..|.:|..:
 Worm   843 LATVREDDNLYDVLALVTRLLAEHP-----AIMIPA-IDKNKALGIIF--------NLLAAPNEL 893

Human  2072 VISPS----GFTAS---------PYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQ--SQKL 2121
            :..|:    ||..|         ....:|..::|.:::.:|    :.:.:.||.::|.:  .:::
 Worm   894 IRIPALKILGFFLSRSTLKRKTESMGNQNLFSLIGERLLSH----KKVLSLPTYNVLLEILVEQM 954

Human  2122 TGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGKEDAFISSCESAKTVCEMEAVLSAQVS 2186
            |.:.            ||...|..:......:..|.|..... ||.||.::.:.:::.....
 Worm   955 TPTF------------TYACHQPAQPEWKFENPHLLKVIAHV-ISQCEESENIVQIKKCFLI--- 1003

Human  2187 VSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLASFQRSHSTIASLGLAFP 2251
                                                     |.:......:.:..||..:.:
 Worm  1004 -----------------------------------------DIINLCRESKENRRTILQMSV--- 1024

Human  2252 SQNGSAAVGRWPSLVDRNTDDWENFAYSLGYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLL 2316
                                 |:::...|.|.  ::.|.|.:.|:|  ||      :|..|   :
 Worm  1025 ---------------------WQDWLIGLAYV--FHTTESQNEVSE--LV------WEAFS---I 1055

Human  2317 ILPDVLLEDVMDKLIQADTLLVLVNHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLAN 2381
            :|...|..:.....:..|||.:.  |...:.::...||.:|.......|...:..|     :...
 Worm  1056 LLHHALRNEYGGWRVWVDTLAIA--HSKVSFEKFKRKLAEAKIKAERSESGGEEAK-----MEPT 1113

Human  2382 QLY---------LH-RGTQELLECFIEMFFGRHIGLDEEFDLEDVRNMGLFQKWSVIPILGLIET 2436
            .:|         :| |...:||.           |::...|           :|.|      .|.
 Worm  1114 PIYRAPEFAWSDVHVRLLADLLS-----------GIERVVD-----------EWKV------AEC 1150

Human  2437 SLYDNILLHNALLLLLQILNSCSKVADMLL--DNGLLYVLCNTVAALNGLEKNIPMSEYKLLACD 2499
            .:.|........:.:..:::..|:::|.|:  ..|||.:|.:..|..|.:|...|        |.
 Worm  1151 GISDQCNASENQVFVGNVVHVVSQLSDSLIMACGGLLPLLASATAPNNDMEIVDP--------CQ 1207

Human  2500 IQQLFIAVTIHACSSSG--SQYFRVIEDLIVMLGYLQNSKNKRTQNMAVALQLRVLQAAMEFIRT 2562
             |||.|:|      |:|  .::.|:::..::..| :..|:.::.:||...   .||:.::....|
 Worm  1208 -QQLPISV------SAGFLMRFARLVDTFVLASG-VSFSELEQEKNMPAG---GVLRQSLRISAT 1261

Human  2563 -TANHDSENLTDSLQSPSAPHHAVVQKRKSIAGSIPMKGSIIPHLPRHHFGSYGQLPMPFSFGPL 2626
             |..|   .|...:|.|..|.:.....:|:                        |..|.|....|
 Worm  1262 VTVRH---ILASRIQQPDTPRYETNSTKKN------------------------QCIMEFVREAL 1299

Human  2627 NQDSSPQFSPGCTTCVVPPGAGPRKFPLAQTESLLMKMRSVANDELHV--MMQRRMSQENPSQAT 2689
            .:.|             |.|       |...|.|:..     :|...:  ::.|.|.:|| .||.
 Worm  1300 EKRS-------------PDG-------LENVERLVQD-----SDITRIKGVVYRDMVEEN-RQAQ 1338

Human  2690 ETELAQRLQRLTVLAVNRIIYQEFNSDIIDILRTPENVTQSKTSVFQTEISEENIHHEQSSVFNP 2754
            ...|:. :..::||.|:|  |:       |||..|.:.:....|..|.:.:.||::.|.|.....
 Worm  1339 FLALSV-IYLVSVLMVSR--YR-------DILEPPSSPSPFFDSTTQKQENSENVNSETSPENGS 1393

Human  2755 FQKEIFTYLVEG-----FKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLLVHILSPAHAAQE 2814
            ..|     |..|     .|..|.|:...|.:::      :.:|......||:..  :..|:|..:
 Worm  1394 NGK-----LANGGDNLSIKNGIESNGNDGEEEE------NGEEGQGDDGGRIAA--IKVANADMK 1445

Human  2815 R-------KQIFEIVHEPN---------------HQEILRDCLSPSLQHGAKLVLYLSELIHNHQ 2857
            |       ::....:|:.|               .:..|...|..:|:..|.|   |.|::.:.:
 Worm  1446 RGDGNEYDEEELSKMHQSNGRRPSTMMPVQQTAERRAYLTTKLQTALETCAPL---LREMMSDFR 1507

Human  2858 GELTEEELGT-AELLMNALKLCGHKCIPPSASTKADLIKMI-----KEEQKKYETEEGVNKAAWQ 2916
            |.|.:..||| .:.:||..|:     :....:..|.:|:::     :|.|...:...|:   |:.
 Worm  1508 GYLQKTLLGTHGQEIMNDTKV-----LETLRNRNASVIELVMLLCSQEWQTSLQKHAGL---AFI 1564

Human  2917 KTVN-----------------NNQQSLFQRLDSKSKDISKIA---ADITQAVSLSQGNERKKVIQ 2961
            :.||                 |....:..||  :::|:||.|   |:..:.::.......:..:.
 Worm  1565 ELVNEGRLMAHATRDHVLRVANEADFILNRL--RAEDVSKHAQFEAESREQLAARHEEYGRCDLL 1627

Human  2962 HIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNK 3026
            ...|..:..::|:|    |:::::...:...|.......|:||..|..:|.|:|.      :||.
 Worm  1628 IASGRLRDSINATR----LLEKMSAILSDQDDSKSGTQFWKLDVWEDDSRRRKRF------VPNA 1682

Human  3027 Y-------LLRDRQKSE-------DVVKPPLSYLFEDKTHSSFSSTVKDKA-------------A 3064
            |       .|.:.:|:|       :.::..|..||..:.:||.|..:.|::             :
 Worm  1683 YGSRHEEANLPEGEKNEEPEISEQEKIRKVLKGLFSKRQNSSGSHELVDESDIDKWAQEVDPTPS 1747

Human  3065 SESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASD---TVESSSLQGELEPASFSWTYEEI 3126
            |:|...:.....:||.....|.|.:....::| :.|.||   ..:.:.:....|.....|..:||
 Worm  1748 SQSACFSTTAKLIAPGVVVPGTLSVTANDLFF-DANESDPNYKKQCAQVLRYCEALHARWNLQEI 1811

Human  3127 KEVHKRWWQLRDNAVEIFLTNGRTLLLAFDN-TKVRDDVYHNILTNNLPNL---LEYG----NIT 3183
            :.:..|.:.|::.|:|:||.:...::.|||: ..|:..||      .||.:   ::||    ..|
 Worm  1812 RAIFLRRYLLQNTALELFLASRTAIMFAFDSEDAVKKVVY------QLPRVGVGVKYGLPQSRKT 1870

Human  3184 ALTN------------LWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLND 3236
            :|..            .|...:|:||:||..||..|||:||||.||||||:||.:|.|:||||:.
 Worm  1871 SLMTPRQLFKHSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSV 1935

Human  3237 LLIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFL 3301
            ...:|:|||||....:.:...:.|.|.         :.:||.:|   .:|||:|||.....|::|
 Worm  1936 ASNFRDLSKPIGALSEARRKFFNDRYT---------SWDDDQVP---AFHYGTHYSTPAFTLNWL 1988

Human  3302 VRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDF 3366
            :|:.||..||:...|..||.|||..||...:|.....:| .||||||||.|||||...|...|:.
 Worm  1989 LRVEPFASMFINLHDGKFDHPDRITHSIKDSWDRCQRDS-HDVKELIPELFYLPEMFRNSSKFNL 2052

Human  3367 GVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINV 3431
            |.|.:|..|:.|.|||||.: |..|:|:||||||||.||..:.|||||:|||||:|..:|:|.||
 Worm  2053 GRRADGTPVDDVVLPPWAES-PEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNV 2116

Human  3432 FHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAAVGLLV 3495
            |:..||.| :.....|.|.|..|:|..|.::||||.||...||..|            .::..:.
 Worm  2117 FYHLTYEGTVTPKMAETPGQVAAIEQQILSFGQTPSQLLTEAHPPR------------HSIMSMA 2169

Human  3496 QFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICG 3560
            ...||...|.:..:.              :|:.:.    |||..:.      .:...||...:.|
 Worm  2170 PTMFRRHDEDLCMMM--------------KYISNS----PVVYLAA------NTFHQLPQPTVVG 2210

Human  3561 LSRNFCLLM-----TYSKEQGVRSMNSTDI-----QWSAILSWGYADNILRLKSKQSEPPV---- 3611
            :::|....:     :||.....||..|.|.     |.|..|:   ||  .:|.|..|..||
 Worm  2211 VAQNLVFSLNKWDNSYSYGASQRSALSMDPSNAEGQVSLPLT---AD--AQLASAASTTPVARRH 2270

Human  3612 --------------NFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMET 3662
                          ||:.::....:.:|.: ||               |:.|...:....:...
 Worm  2271 LGDAFDQRLTVQCSNFVTTTDSKFIFACGY-PD---------------YSFRIVDTDSGRVRQA- 2318

Human  3663 QIHLYGHTEEI-------TSLFV-CKPYSILISVSRDGTCIIW-----------DLNRLCYVQS- 3707
               :|||.:.:       ||||. |    .:::.|.|.|.::|           :.|:...|.|
 Worm  2319 ---VYGHGDVVTCIARSETSLFSDC----YVVTGSMDCTVVLWHWNGTTGFIAGEYNQPGEVPSP 2376

Human  3708 ---LAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPE 3769
               |.||::.::|:..|...|.:.:.|:.    ..:.:.|.:.||:..:....|:..::.|.:
 Worm  2377 RSILTGHEASISALCVSAEHGLVVSGCED----GVILIHTTSSDLLRRIRGHGIVTQLSMSRE-- 2435

Human  3770 GVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNK---------PIISLTFSCDGHHLYTANS 3825
                           ..|.|.:|.|  |.:|:..:.|         .|..:|.:.||....|...
 Worm  2436 ---------------CILLSLFDSK--RMVTYSATAKKLDEVLVDDKIECVTVTRDGEFAVTGAV 2483

Human  3826 DGTVIAW 3832
            :|.:..|
 Worm  2484 NGRINIW 2490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LYST	XP_011542333.1	PH_BEACH	3066..3171	CDD:275391	25/108 (23%)
		Beach	3186..3476	CDD:214982	134/302 (44%)
		WD40 repeat	3582..3619	CDD:293791	14/59 (24%)
		WD40	3583..3832	CDD:475233	58/303 (19%)
		WD40 repeat	3623..3668	CDD:293791	5/44 (11%)
		WD40 repeat	3673..3709	CDD:293791	12/58 (21%)
		WD40 repeat	3716..3749	CDD:293791	5/32 (16%)
		WD40 repeat	3759..3800	CDD:293791	6/40 (15%)
sel-2	NP_001379017.1	Laminin_G_3	384..530	CDD:463865	30/223 (13%)
		DUF4704	595..1080	CDD:464870	109/632 (17%)
		DUF1088	1569..1733	CDD:461925	33/175 (19%)
		PH_BEACH	1757..1854	CDD:434260	24/103 (23%)
		Beach	1887..2162	CDD:460459	134/288 (47%)
		NBCH_WD40	2187..2532	CDD:466575	71/366 (19%)
		WD40 repeat	2283..2321	CDD:293791	7/57 (12%)
		WD40 repeat	2327..2382	CDD:293791	13/58 (22%)
		WD40 repeat	2387..2422	CDD:293791	7/38 (18%)
		WD40 repeat	2430..2462	CDD:293791	8/50 (16%)
		WD40 repeat	2466..2502	CDD:293791	7/25 (28%)