DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F8 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	162/545 - (29%)
Similarity:	255/545 - (46%)	Gaps:	87/545 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    19 WLLLLVVGASWLLARILAWTYAF---YH------------NGRRLRCFPQPRKQNWFLG------ 62
            ||:|       .|:.:|.|.:..   ||            :|..:.......|.....|
  Fly     5 WLIL-------ALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLY 62

Human    63 ---HLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVF 124
               |.|:...:.|..:.:......|..|        ..|.|:...|...:|:|..:.|| |.:|
  Fly    63 GRDHAGVFNYSRERAKEMGTSYIEYVFG--------KAIYNIIDADSAENVLNHPNLIT-KGLV- 117

Human   125 YKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIF-SKSANIMHAKWQRLAMEGSTC 188
            |..|.|:|..|||.|.|.||...|::|||.||||||..:.:|| ::|...:      |..||.
  Fly   118 YNFLHPFLRTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFL------LQFEGQ-- 174

Human   189 LDVFEHISLMTLDSLQKCIFSFDSNCQ-----------EKPSEYITAIMELSALVVKRNNQFFRY 242
                :.:::...|.:.:  |:.:|.|:           ||...|.....::....::|.:....:
  Fly   175 ----DEVTITLHDVIPR--FTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLW 233

Human   243 KDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTL-------TSQGVDDFLQAKAKSKTLDFID 300
            .|.|:.:. ..:.|..|..:||.|:..:|.:||..|       :|...||...:|   |....:|
  Fly   234 GDKLFEMF-AAKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSK---KRFAMLD 294

Human   301 VLLLSEDKNGKELSDE-DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364
            .|:.:| |:|  |.|. .|..|.||.||.|:|||:.||.:.|.|::.:|:.||.|.||:||.:.|
  Fly   295 TLIYAE-KDG--LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDD 356

Human   365 REPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHH 429
             :...::...|.:|.:|...:||:.||.|.:|...|...|:..|.:..::|||....|::|.||.
  Fly   357 -DLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHR 420

Human   430 NPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPD 494
            |...|..||.:.|.||.|||.|.|...|::|||||.|||||:|:||.|||.::.:.|.:|::| .
  Fly   421 NAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVL-K 484

Human   495 HREPRRT---PEIVLRAEDGLWLRV 516
            ..:|::.   ..|.||.:|.:.:::
  Fly   485 AIDPQKIVFHTGITLRTQDKIRVKL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	149/483 (31%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	152/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850