DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4F8 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	166/445 - (37%)
Similarity:	250/445 - (56%)	Gaps:	29/445 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    91 WLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAF 155
            |.| ..|.:.|..|:.|..::|:...:....  .|..|.||||:|||.|...||...|::|||||
  Fly   101 WQG-TAPRVLLFEPETVEPILNSQKFVNKSH--DYDYLHPWLGEGLLTSTDRKWHSRRKILTPAF 162

Human   156 HFNILKPYIKIFSKSANIMHAKWQRLAME-GSTCLDVFEHISLMTLD-----SLQKCIFSFDSNC 214
            ||.||..:|.:|::.:.::..|   ||:| ||...::|.:::|.|||     ::.:.|:: .||.
  Fly   163 HFKILDDFIDVFNEQSAVLARK---LAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYA-QSNS 223

Human   215 QEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTL- 278
            :   |||:.|:..:.::|..|..:.:...||::.||...:........:|.|::.||:||:..|
  Fly   224 E---SEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELA 285

Human   279 --------TSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTAS 335
                    .:....|......|.|.|.|:| ||:...|.|..||:||||.|.|||||.|||||::
  Fly   286 ILQENNNNNNNNAPDAYDDVGKKKRLAFLD-LLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSA 349

Human   336 GLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFAR 400
            .:||.|:.|..|||||||..:|:..:..|.:.......:|..:.:|..|:|:||||.|.:|..||
  Fly   350 AISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMAR 414

Human   401 GCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGP 465
            ...:||.: ..:::|.|....|..:|:|.||.|:|.||.::|..|.|||...|.|.|:|||||||
  Fly   415 MVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGP 478

Human   466 RNCIGQKFAMAEMKVVLALTLLRFRI-LPDHREP-RRTPEIVLRAEDGLWLRVEP 518
            |||||||||:.|.|.|::..|.:::| ..|.||. ....|::||.:|||.:::.|
  Fly   479 RNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITP 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	159/429 (37%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	165/441 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650