Protein Alignment CYP4F8 and Cyp4d8

DIOPT Version :9

• Sequence 1: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 171/547 - (31%)
• Similarity: 266/547 - (48%)
• Gaps: 107/547 - (19%)

Human    20 LLLLVVGASWLLARILAWTYAFYHNG-----RRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQ 79
            |::|:.||.|::           |.|     |::...|.|           :..|....::::.:
  Fly     6 LVVLLFGAGWII-----------HLGQADRRRKVANLPGP-----------ICPPLIGAMQLMLR 48

Human    80 LVATYPQGFVR---------------WLGPITPIINLCHPDIVRSVINTSDAITDKDIV------ 123
            |   .|:.|::               |      |.|       |.:|.:.||..::.::
  Fly    49 L---NPKTFIKVGREYVLKFGHLQRVW------IFN-------RLLIMSGDAELNEQLLSSQEHL 97

Human   124 ----FYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAME 184
                .||.|..|||:|||||.|..|...|:::||.|||:||:.::::|.:.:||.   .||||.:
  Fly    98 VKHPVYKVLGQWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNIC---VQRLAQK 159

Human   185 --GSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPS-EYITAIMELSALVVKRNNQFFRYKDFL 246
              |:| .||:..|....||.:.:.........|...| .|..|:.|.:||:..|....:...:.|
  Fly   160 ANGNT-FDVYRSICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELL 223

Human   247 YFLTPCGRRFHRA--CRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLD------------ 297
            :.||....::.:.  .|.:.:||..||::||:.|..|          :||.:|
  Fly   224 FTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALEDQ----------QSKLMDTADEDVGSKRRM 278

Human   298 -FIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
             .:||||:| ..:|:.|::::||.|.|||||.|||||.|.||:.|:.|:||||.|.:..:|:.::
  Fly   279 ALLDVLLMS-TVDGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQV 342

Human   362 LKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS----RVIPKGNVCNI 422
            |.....:.:...||.:|.::...:|||||::||:|...|....|.....|    .|||.|:...|
  Fly   343 LGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIII 407

Human   423 NIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLL 487
            .||.:|..|..:|:|:.:.|.|.  ||..:.:|...||||||||||||||||..|||::||..:.
  Fly   408 GIFGVHRQPETFPNPDEFIPERH--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR 470

Human   488 RFRILPDHREPRRTPEIVLRAEDGLWL 514
            .:.:||..:.......||||:|.|..|
  Fly   471 EYELLPMGQRVECIVNIVLRSETGFQL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	156/498 (31%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	156/460 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750