Protein Alignment CYP4F8 and Cyp6a8

DIOPT Version :9

• Sequence 1: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Alignment Length: 455
• Identity: 116/455 - (25%)
• Similarity: 214/455 - (47%)
• Gaps: 49/455 - (10%)

Human    87 GFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLL 151
            ||..:..|...:|:|   ::.:.::....:......:||......:...|....|.:||..|..|
  Fly    75 GFFFFQSPAAFVIDL---ELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRNKL 136

Human   152 TPAFHFNILK----PYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDS 212
            :..|....:|    ..:.:.::...:||.|     :..::.|::.:.::..|:|.:..|.|....
  Fly   137 SSTFTSGKMKLMYPTVVSVANEFMTVMHEK-----VPKNSVLEIRDLVARFTVDVIGTCAFGIQC 196

Human   213 N-CQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH--RACRLVHDFTDAVIQER 274
            | .:::.:|::  .....:||.||:....  ..|:.......|:..  |....:.:|...::.|
  Fly   197 NSLRDEKAEFL--YFGKRSLVDKRHGTLL--NGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTE- 256

Human   275 RRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKE-----------LSDEDIRAEADTFMFG 328
              |:.       ::.|...|..||:|:|:  |.||.||           |:.|::.|:|..|...
  Fly   257 --TVA-------VREKEHIKRNDFMDMLI--ELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIA 310

Human   329 GHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHP 393
            |.:|::|.:.:.||.||::|:.|::.|.||:|:::..: :...::....|.:|...|.|:|||:.
  Fly   311 GFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHD-QNFTYECTKDLKYLNQVLDETLRLYT 374

Human   394 PIPTFARGCTQDVVLP--DSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPM 456
            .:|...|...:..|:|  .:.||..|....|...||||:||::|:|..:.|.||.||.:..|..:
  Fly   375 IVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSV 439

Human   457 AFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPR----RTPEIVLRAEDGLWLRVE 517
            |::||..|||||||.:|...:.::.|||.:..|:.....:.|.    .....||..:||::|:||
  Fly   440 AWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKVE 504

Human   518  517
              Fly   505  504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	109/440 (25%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	114/452 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810