Protein Alignment CYP4F8 and Cyp4d21

DIOPT Version :10

• Sequence 1: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 167/535 - (31%)
• Similarity: 266/535 - (49%)
• Gaps: 65/535 - (12%)

Human    19 WLLLLVVGASWLLARILAWTYAFYHNGR---RLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQL 80
            |:||.:.    :|...|.|     .|.|   |:..|.:.|    .||.. .:.....||:.||
  Fly     2 WILLGIA----VLIMTLVW-----DNSRKQWRVNTFEKSR----ILGPF-TIPIVGNGLQALT-- 50

Human    81 VATYPQGFVRWLGPITP---------IINLC---HPDI--VRSVINTSDAITDKDIVFYKTLKPW 131
              ..|:.|::..|....         |:..|   ..|:  ..|::::|..:  |....|:.|:.:
  Fly    51 --LRPENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLL--KKAHLYRFLRDF 111

Human   132 LGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHIS 196
            ||||||||.|:||...|::|.|||||..|:.:::|..:::.||..|.:..| :|.||:|:|:.:|
  Fly   112 LGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGKTCVDLFKFVS 175

Human   197 LMTLDSLQKCIFSFDSNCQEKPS-EYITAIMELSALVVKR-NNQFFRYKDFLYFLTPCG-----R 254
            |..||...:.......|.|.:|: .|..|:..:..:..|| .:...||.    :|.|..     |
  Fly   176 LEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYN----WLFPLAAPLVYR 236

Human   255 RFHRACRLVHDFTDAVIQERRRTL---TSQGV-------DDFLQAKAKSKTLDFIDVLLLSEDKN 309
            |..:...::.||||.||:|||..|   .:.|.       ||.:..|||...||    :||....:
  Fly   237 RLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----ILLQATID 297

Human   310 GKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDD 374
            .|.|||.|||.|.|.|:|.|.|||.||:|..|:.::|||:.||...:|:..:|.......:....
  Fly   298 NKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTK 362

Human   375 LAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEV 439
            |.:|.:|...:||::|||||:|...|...:|:.:.:. .||......:..:.::.:|..:|||.|
  Fly   363 LLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEI-TIPGNTSILLMPYYVYRDPEYFPDPLV 426

Human   440 YDPFRF-DPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPE 503
            :.|.|: |.:......|:|:||||:||:||||||||..:||.:::..:..:.:||...:.:.|..
  Fly   427 FKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYT 491

Human   504 IVLRAEDGLWLRVEP 518
            .:|.:..|..:.::|
  Fly   492 FILSSSTGNNVGLKP 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	152/472 (32%)
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	146/445 (33%)