Protein Alignment CYP4F8 and Cyp318a1

DIOPT Version :9

• Sequence 1: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_727590.1
• Gene: Cyp318a1 / 32172
• FlyBaseID: FBgn0030369
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 591
• Identity: 126/591 - (21%)
• Similarity: 226/591 - (38%)
• Gaps: 156/591 - (26%)

Human    20 LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFL-GHLGLVTPTEEGLRVLTQL--- 80
            :.|...||  |||.:|||        ::.:|:    :..|.| |..|::......|.:...|
  Fly     5 IALWACGA--LLAVLLAW--------QQRKCW----RLIWQLNGWRGVIQQPVLWLLLCINLHPN 55

Human    81 -----VATYPQGFVRWLGPIT---PIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGD--- 134
                 |:.|...|.|.|..:.   .::.:..|..:..|:|..:.:.          |.:|.|
  Fly    56 SILEKVSQYRVHFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECLD----------KTFLQDGFF 110

Human   135 ---GLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR------LAMEGSTCLD 190
               |||.:.|.||:..|:.|.|||..||:..:..:|:...|.|..::|.      .|::.:...|
  Fly   111 VRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAED 175

Human   191 VFE----HISLMTLDSLQKCIFSFDSNCQEKPSEYIT----AIMELSALVVKRNNQFFRYKDFLY 247
            :..    .:|.:|       |....:|..:....:|.    .::|:||:.|        .|.:|.
  Fly   176 LLSRAVLEVSCLT-------IMGTPTNFTQLDDAHIAHSYKRLLEISAVRV--------VKPWLQ 225

Human   248 FLTPCGRRFHR------------ACRLVHDFTDAVIQERRRTL--------------TSQG---- 282
            .     |..||            ..:|:.||...:::.:.|..              .|.|
  Fly   226 I-----RLLHRLLAPELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRR 285

Human   283 --VDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLA 345
              ::...|..|                 || |::.|:|..||.:.:....:|.::.:...|..||
  Fly   286 IFIEQIFQLAA-----------------NG-EMTLEEIMDEAQSMVLVSFETVSNSIMLALLCLA 332

Human   346 RHP-EYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLP 409
            .:. :.|.|...|::.|:.|  ..::..:.|.||.:|...:.|||||...:|...|..::|..|.
  Fly   333 TNKGDCQRRLLAEIRALVPD--VGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLA 395

Human   410 DSR---VIPKGNVCNINIFAIHHNPSVW-PDPEVYDPFRF-DPENAQ------------------ 451
            ..:   ::|:.::..::.|.:..:...| .:...:||.|| |.|..|
  Fly   396 GRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRD 460

Human   452 KRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPR----RTPEIVLRAEDGL 512
            :|...:|:|||.|.|:|||:::.:..|||.|...:..|....|....:    ....:..:..|.:
  Fly   461 RRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSDFELEKLQFVENISLKFKNADDI 525

Human   513 WLRVEP 518
            .|.::|
  Fly   526 LLTIQP 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	113/543 (21%)
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	108/510 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820