DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POU6F2 and nub

DIOPT Version :9

Sequence 1:	NP_001357888.1	Gene:	POU6F2 / 11281	HGNCID:	21694	Length:	720	Species:	Homo sapiens
Sequence 2:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	975	Identity:	205/975 - (21%)
Similarity:	329/975 - (33%)	Gaps:	376/975 - (38%)

- Green bases have known domain annotations that are detailed below.

Human     2 HARNPHSPFQRQHMMDCYLSAQQDTGTMQAVIGQ-------DPMIAG-----QVSKPLLSVRSEM 54
            |.:..|....:|.::..:::.......:..:.||       ..:||.     |..:|..:::||.
  Fly    57 HHQQQHQLLLQQQLLQQHVANSSPLQHLSNLFGQHLPTHSLQHLIAAEYWQQQQQQPAATIKSEP 121

Human    55 NAELRGEDKAATSDSELNEPLLAPVESNDSEDTP-------SKLFGARGNPALSDPGTPDQHQAS 112
            ..    :..||||....               ||       :.|...:.|.||     |::..|:
  Fly   122 TT----QSVAATSVFSF---------------TPQQHVNFAASLVALQQNDAL-----PEETMAT 162

Human   113 QTHPPFP------------VGPQPLL-------TAQQLASAV------------------AGV-- 138
            .|..|.|            |...|..       ||.|.|:.:                  |||
  Fly   163 ATATPTPATTASGAATAAAVATSPAAATTLKAPTATQAAATMDDIDDDDDDSNNGGHMQNAGVGN 227

Human   139 ---MPG---GPPALNQPILIPF--NMAGQLGGQQGLVLTLPTANLTNIQG------LVAAAAAGG 189
               .||   |.|| |:.:|...  |..|        .||....|:.::..      |.::.|:..
  Fly   228 FKFEPGQQLGTPA-NEAVLTSSEENKDG--------TLTAVDTNMRDVSANHSSSFLSSSPASST 283

Human   190 IMT-------LPL-------------------------------------QNLQATSSLNSQL-Q 209
            :::       |||                                     :.||.....|... .
  Fly   284 LVSCHSPSPPLPLLADQDDGTRRMRDKKLTLELKLQSCDEYVEQPKDKGAERLQPAQIANDNAPS 348

Human   210 QLQLQLQQQQQQQQ-------------------------------------QQPPPSTNQHPQPA 237
            .|.|:|::|.:|:|                                     |.|...:.....|:
  Fly   349 PLHLKLEEQDEQEQADVKDKVLELTGAAVALYGHLNNASKDVRDLEQCLKLQDPNDISRLSRSPS 413

Human   238 PQAPSQSQ---------------QQPLQPTPPQQPPPASQQPPAPTSQLQQAPQPQQHQPH---- 283
            |...:.|.               :.||.|....    :.||.......||..|....|.||
  Fly   414 PLQSNASDCDDNNSSVGTSSDRCRSPLSPALSL----SHQQAKRQLMSLQPHPAHHHHNPHHLNH 474

Human   284 -SHSQNQNQPS-----------PTQQSSSPPQKPSQSPGHGLPSP---LTPPNPLQLVNNPLASQ 333
             :|.|.:.:..           .:..|....|.||.|......||   ::.|:|:..:.:|:.:.
  Fly   475 LNHHQYKQEEDYDDANGGALNLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPPMISPVLAP 539

Human   334 AAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSS-QAASGTQGLQV 397
            :...:...:|:|::.|...|::|..|             .|..||:..||.|| ||.....||.:
  Fly   540 SGCGSTTPNSMAAAAAAAAAVASTMG-------------SGISPLLALPGMSSPQAQLAAAGLGM 591

Human   398 Q------PITP-------QLLTNAQGQIIATVIGNQILPVINTQGITLSPIKP--------GQQL 441
            .      .::|       |||  .|.|:..|...|..:.::.:..:.|:...|        .|.|
  Fly   592 NNPLLTGSLSPQDFAQFHQLL--QQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFL 654

Human   442 HQPSQTSVGQAASQ------------GNLLHLAH--SQASMSQSP--------VRQASSS----- 479
            .|....::.||:.|            ...|.|.|  :|...|.:|        :|..:||
  Fly   655 MQSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLH 719

Human   480 ------------SSSSS-------------SSSALSVGQLVSNPQT--------AAGE---VDGV 508
                        ||::|             |.:.:|.|.....|:|        ||||   .:..
  Fly   720 HHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETT 784

Human   509 NLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIA 573
            :|||:.:|||.||.||:.||.||..||.|:....|..:||:.|
  Fly   785 DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI---------------------- 827

Human   574 SSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHR--------AGMQ---NLTE 627
                          :|||.|:::.|:..|:||:|::|:.:|:...:        |.:|   :..|
  Fly   828 --------------SRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPE 878

Human   628 FIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 692
            .||    ::||:|||........|...|..|..|:.:|:|::|::|:.::|||||||||:||..|
  Fly   879 IIG----RRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEK 939

Human 693 692
Fly 940 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POU6F2	NP_001357888.1	Pou	506..615	CDD:389985	31/108 (29%)
POU6F2	NP_001357888.1	Homeobox	639..693	CDD:365835	23/54 (43%)
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409	9/83 (11%)
		POU	791..855	CDD:197673	28/99 (28%)
		Homeobox	886..939	CDD:278475	22/52 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810