Protein Alignment CHRM1 and Octbeta1R

DIOPT Version :10

• Sequence 1: NP_000729.2
• Gene: CHRM1 / 1128
• HGNCID: 1950
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 434
• Identity: 111/434 - (25%)
• Similarity: 186/434 - (42%)
• Gaps: 137/434 - (31%)

Human    33 GLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLA 97
            |.:.||.:.||:||::|...:.:|:.:.|||::|||.||:::...:|....:.::.|.|..|::.
  Fly   115 GFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVM 179

Human    98 CDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAIL 162
            ||:|.:.|...|.||:|:|..||.|||:::.:||.|....|.||..:|:.:.||      :||:|
  Fly   180 CDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWL------SPALL 238

Human   163 -FWQYLVGERTVLAGQCYIQFLSQPII---------TFGTAMAAFYLPVTVMCTLYWRIYRETEN 217
             |.....|..|......|::  |.|.|         ...::..:|::|..||.::|:|||:|.:.
  Fly   239 SFLPICSGWYTTTENYKYLK--SNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADR 301

Human   218 RAR-----ELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEE 277
            :.|     ::|||                                          ||:.:
  Fly   302 QERLVYRSKVAAL------------------------------------------LLEKH----- 319

Human   278 EEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQK 342
                      |..|:..:|                .|:.|..:|:.:|::|
  Fly   320 ----------LQISQIPKP----------------RPSIQVEQSTISTMRR-------------- 344

Human   343 PRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCV-PETLWELGYWL 406
                             |:||||||..|:.||::.|.|:.:..:||:.|..|: |..|..:.:|:
  Fly   345 -----------------ERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWI 392

Human   407 CYVNSTINPMCYALCNKAFRDTFRLLL---------LCRWDKRR 441
            .|.||.:||:.||..|:.||..|:..|         .||..:.|
  Fly   393 GYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRGRGR 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRM1	NP_000729.2	7tmA_mAChR_M1	26..429	CDD:341356	106/411 (26%)
		TM helix 1	27..53	CDD:341356	8/19 (42%)
		TM helix 2	60..86	CDD:341356	9/25 (36%)
		TM helix 3	98..128	CDD:341356	14/29 (48%)
		TM helix 4	140..163	CDD:341356	8/23 (35%)
		TM helix 5	185..214	CDD:341356	10/37 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..256		1/30 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..297		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..351		5/40 (13%)
		TM helix 6	358..388	CDD:341356	12/29 (41%)
		TM helix 7	397..422	CDD:341356	9/24 (38%)
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	106/411 (26%)
		TM helix 1	109..135	CDD:320194	8/19 (42%)
		TM helix 2	142..168	CDD:320194	9/25 (36%)
		TM helix 3	180..210	CDD:320194	14/29 (48%)
		TM helix 4	222..245	CDD:320194	9/28 (32%)
		TM helix 5	269..298	CDD:320194	8/28 (29%)
		TM helix 6	343..373	CDD:320194	13/60 (22%)
		TM helix 7	383..408	CDD:320194	9/24 (38%)