Protein Alignment CHRM1 and TyrR

DIOPT Version :10

• Sequence 1: NP_000729.2
• Gene: CHRM1 / 1128
• HGNCID: 1950
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 147/538 - (27%)
• Similarity: 215/538 - (39%)
• Gaps: 135/538 - (25%)

Human    23 WQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLL 87
            ||...:........:.||.||.||:::......|:|:.|.|::|||.|||::|.|.|.......|
  Fly   114 WQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHL 178

Human    88 MGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAAL-MIGLAWL 151
            :|.|.||.:.||:|::||.:...||:::|..||.|||.:|||||:|..||..:|.|| ||.:.||
  Fly   179 IGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL 243

Human   152 VSFVLWAPAILFWQYLVGERTVLAGQC-YIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRI---- 211
            ::..:..|.:|.| |..|.|.:  .:| |.|  ::..:.| :||.:|::|:.||..:|.||
  Fly   244 LALAITCPPMLGW-YEPGRRDL--RECRYNQ--NEGYVIF-SAMGSFFIPMAVMIYVYARISCVI 302

Human   212 -----------------------------------------YRETENR-------AREL------ 222
                                                     .|:..:|       |:||
  Fly   303 ASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLS 367

Human   223 -----AALQGSETPGKGGGSSSSSERS---------QPGAEGSPETPPGRCCRCCRAPRLLQAYS 273
                 ||:......|.|||:||::..:         ..|..||.......|....|...|.:|
  Fly   368 DSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRA-- 430

Human   274 WKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQA------PTKQPPRSSPNTVKRPTKK 332
                   ...|....|.:.|..|||.::.......|..|.      ...||||:..   .|.:..
  Fly   431 -------STASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHS---FRHSHG 485

Human   333 GRDR-----------------------AGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAF 374
            .|||                       :|........:.|:.|.| ||.||.|..:|||.::..|
  Fly   486 ERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRIT-SLKKENKTTQTLSIVVGGF 549

Human   375 ILTWTPYNIMVLVSTF-CKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWD 438
            |..|.|:.|..|::.| .:....:.|.:...||.:.||.|||..||..:..||..|
  Fly   550 IACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF--------- 605

Human   439 KRRWRKIPKRPGSVHRTP 456
               ||...||..|..:.|
  Fly   606 ---WRLTCKRFFSAGQKP 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRM1	NP_000729.2	7tmA_mAChR_M1	26..429	CDD:341356	138/506 (27%)
		TM helix 1	27..53	CDD:341356	6/25 (24%)
		TM helix 2	60..86	CDD:341356	11/25 (44%)
		TM helix 3	98..128	CDD:341356	13/29 (45%)
		TM helix 4	140..163	CDD:341356	8/23 (35%)
		TM helix 5	185..214	CDD:341356	10/73 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..256		9/39 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..297		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..351		11/69 (16%)
		TM helix 6	358..388	CDD:341356	12/29 (41%)
		TM helix 7	397..422	CDD:341356	10/24 (42%)
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	71/191 (37%)
		TM helix 1	118..144	CDD:320189	6/25 (24%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	8/25 (32%)
		7tm_GPCRs	<533..605	CDD:475119	25/71 (35%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)