DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHRM1 and TyrRII

DIOPT Version :10

Sequence 1:NP_000729.2 Gene:CHRM1 / 1128 HGNCID:1950 Length:460 Species:Homo sapiens
Sequence 2:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster


Alignment Length:575 Identity:134/575 - (23%)
Similarity:210/575 - (36%) Gaps:182/575 - (31%)


- Green bases have known domain annotations that are detailed below.


Human     1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLA----------------TVTGNLLVLIS 49
            :.|||    :|...|:|.|.|..::....:.:.|:|:|                ||.||.||:::
  Fly    38 IQTSA----APGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILA 98

Human    50 FKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVM 114
            ......|:||.|.|:::||..|.::||..|.......:.|.|..|.:.||:|::||.:..:.|::
  Fly    99 VLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSIL 163

Human   115 NLLLISFDRYFSVTRPLSYRAKRTPRR-AALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQC 178
            :|..||.|||.:||:||:|..||..:| |.|||.:.|:.:..:..|..|.| |.||........|
  Fly   164 SLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGW-YEVGRHQAEFVDC 227

Human   179 -------YIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRI-YRETENRARELAALQGSETPG--- 232
                   |:.|         :||.:|::|:|||..:|.:| |..|..|.|.:.......|..   
  Fly   228 RYNQNKGYVVF---------SAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDV 283

Human   233 KGGGSSSSSE-------------RSQPGAEGSPETPPG--------------RCCRCCRAPRLLQ 270
            .|....|.||             :|:.......:.||.              :|.:|.:.     
  Fly   284 DGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKC----- 343

Human   271 AYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIK-------------------------------- 303
                           .|.|.:.|...|:.||.|                                
  Fly   344 ---------------SSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKY 393

Human   304 -----------MPMVDPEAQAP--------TKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQL 349
                       |..|..||...        :.....::.|||...|.:..:...|      ::|.
  Fly   394 GGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAK------QKQQ 452

Human   350 AKRKTF------------------------------SLVKEKKAARTLSAILLAFILTWTPYNIM 384
            .:|.:|                              :..::.|.|:||:.::...|..|.|:.:.
  Fly   453 QQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVY 517

Human   385 VLVSTFCKDCVPETLWELGY---WLCYVNSTINPMCYALCNKAFRDTFRLLLLCR 436
            .|:..|...  |..|.:|.:   |:.:||..|||..||..|..||..| ..|.||
  Fly   518 YLLIPFLPR--PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF-WRLTCR 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRM1NP_000729.2 7tmA_mAChR_M1 26..429 CDD:341356 122/541 (23%)
TM helix 1 27..53 CDD:341356 9/41 (22%)
TM helix 2 60..86 CDD:341356 8/25 (32%)
TM helix 3 98..128 CDD:341356 12/29 (41%)
TM helix 4 140..163 CDD:341356 7/23 (30%)
TM helix 5 185..214 CDD:341356 10/29 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..256 6/46 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..297 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..351 8/48 (17%)
TM helix 6 358..388 CDD:341356 8/29 (28%)
TM helix 7 397..422 CDD:341356 10/27 (37%)
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 67/201 (33%)
TM helix 1 78..101 CDD:410628 6/22 (27%)
TM helix 2 110..132 CDD:410628 8/21 (38%)
TM helix 3 148..170 CDD:410628 7/21 (33%)
TM helix 4 194..210 CDD:410628 4/15 (27%)
TM helix 5 233..256 CDD:410628 9/31 (29%)
7tm_GPCRs <491..563 CDD:475119 23/73 (32%)
TM helix 6 497..519 CDD:320098 6/21 (29%)
TM helix 7 531..556 CDD:320098 9/24 (38%)

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