Protein Alignment CHRM1 and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_000729.2
• Gene: CHRM1 / 1128
• HGNCID: 1950
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 437
• Identity: 121/437 - (27%)
• Similarity: 187/437 - (42%)
• Gaps: 123/437 - (28%)

Human    26 AFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGH 90
            ||:.:   |:.:|.:.|||||:||.....:|:.:.|||::|||.||:::...:|....:..:.|.
  Fly   157 AFVML---LIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGR 218

Human    91 WALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAW----L 151
            |......||||.:||...|.||:::|..||.|||:::.:||.|....|.|...:|:...|    |
  Fly   219 WNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPAL 283

Human   152 VSFVLWAPAILFW-------QYLVGERTVLAGQC------YIQFLSQPIITFGTAMAAFYLPVTV 203
            :||:   |..:.|       |:::...|    ||      |...:|..|        :|::|.|:
  Fly   284 LSFL---PIFIGWYTTPQHQQFVIQNPT----QCSFVVNKYYAVISSSI--------SFWIPCTI 333

Human   204 MCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRL 268
            |...|..|:||...:.::|....|           ::....:|..:.|.|...|
  Fly   334 MIFTYLAIFREANRQEKQLMMRHG-----------NAMLMHRPSMQPSGEALSG----------- 376

Human   269 LQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKG 333
                         .||.::||..|.|               :...|||.
  Fly   377 -------------SGSSKTLTLHEVE---------------QEHTPTKD---------------- 397

Human   334 RDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC-VPE 397
                         :.|.|.|     :|.||||||..|:..|||.|.|:.:...:|..|::| ||:
  Fly   398 -------------KHLIKMK-----REHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPD 444

Human   398 TLWELGYWLCYVNSTINPMCYALCNKAFRDTFR---LLLLCRWDKRR 441
            .:..:.:|:.|.|||:||:.||..|:.||:.||   |.|.|.|.|.|
  Fly   445 IVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDR 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRM1	NP_000729.2	7tmA_mAChR_M1	26..429	CDD:341356	113/420 (27%)
		TM helix 1	27..53	CDD:341356	10/25 (40%)
		TM helix 2	60..86	CDD:341356	9/25 (36%)
		TM helix 3	98..128	CDD:341356	15/29 (52%)
		TM helix 4	140..163	CDD:341356	7/26 (27%)
		TM helix 5	185..214	CDD:341356	7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..256		4/30 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..297		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..351		4/40 (10%)
		TM helix 6	358..388	CDD:341356	13/29 (45%)
		TM helix 7	397..422	CDD:341356	9/24 (38%)
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	113/420 (27%)
		TM helix 1	155..181	CDD:320194	11/26 (42%)
		TM helix 2	188..214	CDD:320194	9/25 (36%)
		TM helix 3	226..256	CDD:320194	15/29 (52%)
		TM helix 4	268..291	CDD:320194	7/25 (28%)
		TM helix 5	315..344	CDD:320194	9/36 (25%)
		TM helix 6	404..434	CDD:320194	14/34 (41%)
		TM helix 7	444..469	CDD:320194	9/24 (38%)