DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHRM1 and Octbeta3R

DIOPT Version :10

Sequence 1:NP_000729.2 Gene:CHRM1 / 1128 HGNCID:1950 Length:460 Species:Homo sapiens
Sequence 2:NP_001034048.2 Gene:Octbeta3R / 3885573 FlyBaseID:FBgn0250910 Length:1256 Species:Drosophila melanogaster


Alignment Length:416 Identity:97/416 - (23%)
Similarity:170/416 - (40%) Gaps:83/416 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     9 VSPNIT-----VLAPGKGPWQVAFIGITTGLLS--------LATVTGNLLVLISFKVNTELKTVN 60
            |.||||     :....:...:.:::.::..||.        ||.|.||.||:||.:.|.:|:.:.
  Fly   110 VGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVIT 174

Human    61 NYFLLSLACADLIIGTFSMNLYTTYLLM-GHWALGTLACDLWLALDYVASNASVMNLLLISFDRY 124
            |||::|||.||:::...:|....:..|. |.|..|...|:::.:||...|.||:::|..||.|||
  Fly   175 NYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRY 239

Human   125 FSVTRPLSYRAKRTPRRAALMIGLAWLV-SFVLWAPAILFWQYLVGER----TVLAGQCYIQFLS 184
            :::.|||.|....|.:....|:...|:: :.:.:.|..|.| |...|.    ::...||  .|:.
  Fly   240 YAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGW-YTTEEHLREISLHPDQC--SFVV 301

Human   185 QPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGS--------------------- 228
            .......::..:|::|..||..:||||::|...:.:.|:....:                     
  Fly   302 NKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLH 366

Human   229 -------------ETPGKGGGSSSSSERSQPGAEGS-----------PETPPGRCCRCCRAPRLL 269
                         ||   ....|:..:..||..:..           |..||.|..|.....|.|
  Fly   367 PSDCDLNATSAREET---HSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDL 428

Human   270 QAYSWKEEEEEDEGSMESLTSSEGEEPG-SEVVIKMPMVDPEAQAPTKQPP-------RSSPNTV 326
            :...:::....|  |..|:.:.:.::|. :::....|:.:|:.....|..|       .|.||  
  Fly   429 EQERYEKVTHTD--SAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPN-- 489

Human   327 KRPTKKGRDRAGKGQKPRGKEQLAKR 352
             .|.::....:|.|......|..|.|
  Fly   490 -GPQQQLSLTSGSGNSEPEPESTAYR 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRM1NP_000729.2 7tmA_mAChR_M1 26..429 CDD:341356 92/394 (23%)
TM helix 1 27..53 CDD:341356 11/33 (33%)
TM helix 2 60..86 CDD:341356 9/25 (36%)
TM helix 3 98..128 CDD:341356 12/29 (41%)
TM helix 4 140..163 CDD:341356 3/23 (13%)
TM helix 5 185..214 CDD:341356 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..256 6/75 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..297 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..351 9/47 (19%)
TM helix 6 358..388 CDD:341356
TM helix 7 397..422 CDD:341356
Octbeta3RNP_001034048.2 7tmA_DmOct-betaAR-like 142..>338 CDD:320194 60/198 (30%)
TM helix 1 142..167 CDD:320194 9/24 (38%)
TM helix 2 174..200 CDD:320194 9/25 (36%)
TM helix 3 213..243 CDD:320194 12/29 (41%)
TM helix 4 255..278 CDD:320194 3/22 (14%)
TM helix 5 302..331 CDD:320194 8/28 (29%)
7tm_GPCRs <1161..1234 CDD:475119
TM helix 6 1167..1189 CDD:410628
TM helix 7 1202..1227 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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