Protein Alignment KLF12 and dar1

DIOPT Version :10

• Sequence 1: XP_011533209.1
• Gene: KLF12 / 11278
• HGNCID: 6346
• Length: 415
• Species: Homo sapiens
• Sequence 2: NP_001097493.1
• Gene: dar1 / 38436
• FlyBaseID: FBgn0263239
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 142/456 - (31%)
• Similarity: 196/456 - (42%)
• Gaps: 142/456 - (31%)

Human    34 LMLDGM-PAVR-VKTELLESEQGSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVD 96
            |.|.|: |||. |:.:|.:..|...::.:.....:.|.|     ..|.::|.:...:|.|.....
  Fly   358 LALPGLPPAVDVVELQLQQQHQQQQHLQHNNSSSSSPKL-----ATPGDNSGNTSSYQQQYASQL 417

Human    97 LS------INKARTS--------------------PTAVSSSPVSMTASASS------------- 122
            :|      :|.:.::                    |:|.:|:..|.||:.::
  Fly   418 VSGSGGGYLNGSSSNSYGYSWHSSQSFHTKYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQ 482

Human   123 --------PSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHP 179
                    |::.||.|:|||.::|        |||||:|..:...||...:|..|.
  Fly   483 QQLQQLCPPAAPSTPSTSSSSISS--------SSASSASRHMFVPPLTPPSSDPGS--------- 530

Human   180 VPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGL 244
              |.|.|                      |..|..:......|...|..:   ||....::|.
  Fly   531 --PGSSM----------------------VAAAAAAAAQRRTTPPPPYQQ---GHVMGLINPP-- 566

Human   245 SPRQSKSDSDDDDLPNVTLDSVNETGS--------TALSIARAVQ------------EVHPSPVS 289
                          |.:.|.....|||        |.|:.|.|:|            :..|.|..
  Fly   567 --------------PTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQVPQQQPPPTP 617

Human   290 RV-----RGNRMNNQKFPCS--ISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHL 347
            |.     ||...::|....:  .|..|:.:.|..||: :|:..|||||.|||.||:|||||||||
  Fly   618 RSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRN-NPELEKRRIHHCDFVGCSKVYTKSSHL 681

Human   348 KAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRH 412
            |||:|.|||||||.|.|..|.|:||||||||||||||||.|||||..|:|||:||||||||.:||
  Fly   682 KAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRH 746

Human   413 M 413
            :
  Fly   747 L 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLF12	XP_011533209.1	KLF12_N	40..237	CDD:410608	47/244 (19%)
		COG5048	<241..414	CDD:227381	92/200 (46%)
		C2H2 Zn finger	332..354	CDD:275368	18/21 (86%)
		C2H2 Zn finger	362..384	CDD:275368	16/21 (76%)
		zf-H2C2_2	376..401	CDD:463886	20/24 (83%)
		C2H2 Zn finger	392..412	CDD:275368	13/19 (68%)
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	57/83 (69%)
		C2H2 Zn finger	671..688	CDD:275368	14/16 (88%)
		C2H2 Zn finger	696..718	CDD:275368	16/21 (76%)
		zf-H2C2_2	710..735	CDD:463886	20/24 (83%)
		C2H2 Zn finger	726..746	CDD:275368	13/19 (68%)