DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLF12 and cbt

DIOPT Version :9

Sequence 1:	XP_011533209.1	Gene:	KLF12 / 11278	HGNCID:	6346	Length:	415	Species:	Homo sapiens
Sequence 2:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	105/368 - (28%)
Similarity:	157/368 - (42%)	Gaps:	87/368 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    55 SPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTAS 119
            :||..:..| ||..:.:.|.|....:.::|:      |.|.|..::..:.:........|:.:.:
  Fly    55 TPNPSDTED-EAPEIAVPNKKPRLEQPAMSM------TPPPDQKLDDDQKAERVSVIMRVNSSGA 112

Human   120 ASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPS- 183
            .||.|....||||:|..:||....||.||                               |||:
  Fly   113 VSSSSQDENSSSSTSCCSSSSNTNTSTSS-------------------------------VPPTV 146

Human   184 ----SPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGL 244
                ...|:..|....::|    .::..|....|::|......:|.|
  Fly   147 EDDYPEANVWRNLKFKMNR----KRAAEVALPPVQTPETPVAKLVTP------------------ 189

Human   245 SPRQSKSDSDDDDLPNVTLDSVNETGSTA-----LSIARAVQEVHPSPVSRVRGNRMNNQKFPCS 304
             |..::...:::..|.:|...|:...|:|     ||...|.|.  |:||.:.  ..|:.:|....
  Fly   190 -PAPAECIKEEEIKPILTPIYVSPVASSASQLILLSTVAAQQS--PTPVPKT--PTMSEEKLTTR 249

Human   305 ISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTW 369
            |:.....:||            .||:.|.|..|.|.|.||||||||:|.||||:|:.|.||.|..
  Fly   250 ITAAQAAATR------------SRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDK 302

Human   370 KFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRH 412
            :|:|||||:||.|.|||.|.|:|:.|.:.|.|||||:.|.:||
  Fly   303 RFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLF12	XP_011533209.1	COG5048	<241..414	CDD:227381	68/177 (38%)
		zf-C2H2	330..354	CDD:278523	14/23 (61%)
		C2H2 Zn finger	332..354	CDD:275368	14/21 (67%)
		zf-H2C2_2	346..>363	CDD:290200	11/16 (69%)
		C2H2 Zn finger	362..384	CDD:275368	13/21 (62%)
		zf-H2C2_2	376..401	CDD:290200	13/24 (54%)
		C2H2 Zn finger	392..412	CDD:275368	9/19 (47%)
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	14/23 (61%)
		C2H2 Zn finger	265..287	CDD:275368	14/21 (67%)
		COG5048	<270..362	CDD:227381	46/76 (61%)
		zf-H2C2_2	279..306	CDD:290200	16/26 (62%)
		C2H2 Zn finger	295..317	CDD:275368	13/21 (62%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910