DRSC/TRiP Functional Genomics Resources

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Protein Alignment TREX1 and STS1

DIOPT Version :10

Sequence 1:NP_338599.1 Gene:TREX1 / 11277 HGNCID:12269 Length:314 Species:Homo sapiens
Sequence 2:NP_012276.1 Gene:STS1 / 854828 SGDID:S000001450 Length:319 Species:Saccharomyces cerevisiae


Alignment Length:71 Identity:20/71 - (28%)
Similarity:26/71 - (36%) Gaps:28/71 - (39%)


- Green bases have known domain annotations that are detailed below.


Human   110 AFLRRQPQPW----CLVAHNGDRYDFPL---------LQAELAMLGLTSALDGAFCVDSITALKA 161
            ||:|.:||..    |||       ||.|         |.|.|..|.:        |.:.:..|..
Yeast   154 AFVRMKPQILEFLNCLV-------DFILDNIPPRLENLHASLKFLDI--------CTELVIKLPR 203

Human   162 LERASS 167
            .|.||:
Yeast   204 FELASN 209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TREX1NP_338599.1 DnaQ_like_exo 14..211 CDD:447876 20/71 (28%)
Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0 236..314
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..278
Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357 243..314
Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0 281..314
STS1NP_012276.1 Cut8 63..274 CDD:462518 20/71 (28%)
Blue background indicates that the domain is not in the aligned region.

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