DRSC/TRiP Functional Genomics Resources

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Protein Alignment TREX1 and RNH70

DIOPT Version :10

Sequence 1:NP_338599.1 Gene:TREX1 / 11277 HGNCID:12269 Length:314 Species:Homo sapiens
Sequence 2:NP_011792.1 Gene:RNH70 / 853193 SGDID:S000003508 Length:553 Species:Saccharomyces cerevisiae


Alignment Length:58 Identity:14/58 - (24%)
Similarity:27/58 - (46%) Gaps:17/58 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   159 LKALERASSPSEHGPRKS----------YSLGSIYTRLYGQSPPDSHTAEGDVLALLS 206
            :|.|||:.:.::. |||.          :.:|...|:||..:.|      |.::.::|
Yeast   451 IKNLERSRNYNKK-PRKETPSFDASMVLHDIGQHLTQLYENATP------GTMILIMS 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TREX1NP_338599.1 DnaQ_like_exo 14..211 CDD:447876 14/58 (24%)
Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0 236..314
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..278
Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357 243..314
Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0 281..314
RNH70NP_011792.1 REX1_like 226..374 CDD:99848
Blue background indicates that the domain is not in the aligned region.

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