Protein Alignment TREX1 and PAN2

DIOPT Version :10

• Sequence 1: NP_338599.1
• Gene: TREX1 / 11277
• HGNCID: 12269
• Length: 314
• Species: Homo sapiens
• Sequence 2: NP_011421.1
• Gene: PAN2 / 852786
• SGDID: S000003062
• Length: 1115
• Species: Saccharomyces cerevisiae
• Alignment Length: 231
• Identity: 49/231 - (21%)
• Similarity: 82/231 - (35%)
• Gaps: 67/231 - (29%)

Human    82 SEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPW-----CLVAHNGDRYDFPLLQAELAML 141
            :|.:||...|         |::..|.::...|..|:.:     ||...|   ::..||.....:.
Yeast   502 TEYSGLDPDV---------DNHYTNAIIQLYRFIPEMFNFVVGCLKDEN---FETTLLTDLGYLF 554

Human   142 GLTSALDGAFC--------VDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAE 198
            .:.....|..|        :.|:|..:.||. ..|.||  .:.| |.|:..|   :|..|.:::|
Yeast   555 DMMERSHGKICSSSNFQASLKSLTDKRQLEN-GEPQEH--LEEY-LESLCIR---ESIEDFNSSE 612

Human   199 GDVLALLSICQWRPQALLRW-----VDAHARPFG---TIRPMYGVTASARTKPRPSAVTTTAHLA 255
                   ||.:..||...|:     :...|:...   |:...:|:....||:      .:..|..
Yeast   613 -------SIKRNMPQKFNRFLLSQLIKEEAQTVNHNITLNQCFGLETEIRTE------CSCDHYD 664

Human   256 TTRNTSPSLG--------------ESRGTKDLPPVK 277
            ||....|||.              :|.|...||.::
Yeast   665 TTVKLLPSLSISGINKTVIKQLNKKSNGQNILPYIE 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TREX1	NP_338599.1	DnaQ_like_exo	14..211	CDD:447876	31/141 (22%)
		Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0	236..314		12/56 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..278		12/52 (23%)
		Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357	243..314		10/49 (20%)
		Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0	281..314
PAN2	NP_011421.1	WD40	<168..>328	CDD:441893
		UCH_1	505..829	CDD:463872	48/228 (21%)
		PAN2_exo	907..1080	CDD:99846