DRSC/TRiP Functional Genomics Resources

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Protein Alignment TREX1 and REX3

DIOPT Version :10

Sequence 1:NP_338599.1 Gene:TREX1 / 11277 HGNCID:12269 Length:314 Species:Homo sapiens
Sequence 2:NP_013208.1 Gene:REX3 / 850797 SGDID:S000004097 Length:404 Species:Saccharomyces cerevisiae


Alignment Length:41 Identity:13/41 - (31%)
Similarity:19/41 - (46%) Gaps:9/41 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    87 LSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGD 127
            :.||:|  :.|..|..:|.||....|.|:.|       ||:
Yeast   344 IDTAIL--YSRTKFKVSLKNLAFEVLSRKIQ-------NGE 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TREX1NP_338599.1 DnaQ_like_exo 14..211 CDD:447876 13/41 (32%)
Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0 236..314
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..278
Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357 243..314
Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0 281..314
REX3NP_013208.1 REX1_like 244..390 CDD:99848 13/41 (32%)
Blue background indicates that the domain is not in the aligned region.

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