Protein Alignment TREX1 and Trex1

DIOPT Version :10

• Sequence 1: NP_338599.1
• Gene: TREX1 / 11277
• HGNCID: 12269
• Length: 314
• Species: Homo sapiens
• Sequence 2: NP_035767.4
• Gene: Trex1 / 22040
• MGIID: 1328317
• Length: 314
• Species: Mus musculus
• Alignment Length: 315
• Identity: 231/315 - (73%)
• Similarity: 250/315 - (79%)
• Gaps: 2/315 - (0%)

Human     1 MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVD 65
            ||||.||.|.||||||.|:||||||.|:|:|||||||||||.|||:...|||.||.||.||||||
Mouse     1 MGSQTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVPRPPRVVD 65

Human    66 KLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYD 130
            |||||:||||||||.||||||||.|.|...|||.||||||.||.|||:|||||.|||||||||||
Mouse    66 KLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFLQRQPQPCCLVAHNGDRYD 130

Human   131 FPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSH 195
            |||||.|||.|...|.|||.||||||.||||||:|||||.:|.||||||||||||||.|:|.|||
Mouse   131 FPLLQTELARLSTPSPLDGTFCVDSIAALKALEQASSPSGNGSRKSYSLGSIYTRLYWQAPTDSH 195

Human   196 TAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTA-SARTKPRPSAVTTTAHLATTRN 259
            |||||||.|||||||:|||||:|||.|||||.|::||||..| :..|..||.|.|.|..|||. |
Mouse   196 TAEGDVLTLLSICQWKPQALLQWVDEHARPFSTVKPMYGTPATTGTTNLRPHAATATTPLATA-N 259

Human   260 TSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE 314
            .|||.|.||..|..||.|.|.|.|:|||||||.||.:||||:||||||.||:||:
Mouse   260 GSPSNGRSRRPKSPPPEKVPEAPSQEGLLAPLSLLTLLTLAIATLYGLFLASPGQ 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TREX1	NP_338599.1	DnaQ_like_exo	14..211	CDD:447876	155/196 (79%)
		Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0	236..314		46/78 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..278		19/37 (51%)
		Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357	243..314		44/70 (63%)
		Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0	281..314		24/32 (75%)
Trex1	NP_035767.4	TREX1_2	14..211	CDD:99839	155/196 (79%)
		Necessary for endoplasmic reticulum localization. /evidence=ECO:0000269|PubMed:18724932	236..314		46/78 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..284		23/47 (49%)
		Interaction with UBQLN1. /evidence=ECO:0000250|UniProtKB:Q9NSU2	244..314		44/70 (63%)
		Necessary for cytoplasmic retention. /evidence=ECO:0000269|PubMed:18724932	281..314		24/32 (75%)