DRSC/TRiP Functional Genomics Resources

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Protein Alignment TREX1 and W02F12.4

DIOPT Version :10

Sequence 1:NP_338599.1 Gene:TREX1 / 11277 HGNCID:12269 Length:314 Species:Homo sapiens
Sequence 2:NP_001256068.1 Gene:W02F12.4 / 179062 WormBaseID:WBGene00020949 Length:401 Species:Caenorhabditis elegans


Alignment Length:192 Identity:32/192 - (16%)
Similarity:63/192 - (32%) Gaps:78/192 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    11 MQTLIFFDMEATGL------------PFSQ--------------------PKVTELCLLAVH--- 40
            ::|.:|||:|.|||            .|::                    |.:||:..:|:.   
 Worm    56 IKTYVFFDLECTGLIKNEDTRNLHARAFNKAEEHYNVLNNLCIETRKDELPYITEMSFMAISSEK 120

Human    41 ------------RCALESPPTSQGPPPTVPP-------PPRVVDKLS------LCVAPGKACSPA 80
                        ...:|:|.:.:.....:|.       .|.::.:..      ..:|.||     
 Worm   121 FDELKAERQKDITWNIENPGSEKPLAKFIPTCTHTRQINPTMMSETEWNSYERFRLAGGK----- 180

Human    81 ASEITGLSTAVLAAHGRQCFDDNLANL----LLAFLRRQPQPWCLVAHNGDRYDFPLLQAEL 138
                     .::....::|..:|....    ::.|.....:|..|:|||..:||..::..||
 Worm   181 ---------GIIVHSKKECQRNNTFKEEWPGVIQFFNSLQKPALLIAHNAIKYDLRVIYGEL 233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TREX1NP_338599.1 DnaQ_like_exo 14..211 CDD:447876 31/189 (16%)
Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0 236..314
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..278
Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357 243..314
Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0 281..314
W02F12.4NP_001256068.1 DnaQ_like_exo 59..265 CDD:447876 31/189 (16%)
Blue background indicates that the domain is not in the aligned region.

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