Protein Alignment TREX1 and plex9.1

DIOPT Version :10

• Sequence 1: NP_338599.1
• Gene: TREX1 / 11277
• HGNCID: 12269
• Length: 314
• Species: Homo sapiens
• Sequence 2: XP_005174272.1
• Gene: plex9.1 / 101886651
• ZFINID: ZDB-GENE-131127-357
• Length: 244
• Species: Danio rerio
• Alignment Length: 238
• Identity: 62/238 - (26%)
• Similarity: 94/238 - (39%)
• Gaps: 79/238 - (33%)

Human    12 QTLIFFDMEATGLPFSQPKVTELCLLA---------VHRCALESPPTSQGPPPTVPPPPRVVDKL 67
            :||:|||:|.|||..|:..:.:|..::         :.||
Zfish    55 ETLVFFDLETTGLDTSRCDIVQLSAISGAQVFSVYLLPRC------------------------- 94

Human    68 SLCVAPGKACSPAASEITGL----STAVLAAHGRQCFDDNLANLLLAFLR-RQPQPW---CLVAH 124
              |:..|      ||::|||    ||.:|.....|......|  |..|:| .|.|.:   .||.|
Zfish    95 --CITEG------ASQVTGLWVDGSTLMLRERPVQTVPHQQA--LTGFIRFLQNQTFGRPILVGH 149

Human   125 NGDRYDFPLLQAELAMLGLTSALD--GAFCVDSITALK-----ALERASSP--SEHGPRKSYSLG 180
            |..|:|:|:|:..|...||.....  .:.|||:::..:     ||::.|.|  .:|..::.|.
Zfish   150 NSRRFDWPILRRVLEEFGLLQEFRSCASECVDTLSLSREMFRNALQKFSQPFLVQHFLQQEYG-- 212

Human   181 SIYTRLYGQSPPDSHTAEGDVLALLSICQ-WRPQALLRWVDAH 222
                         :|.|..||..|..:.: |||...||  |.|
Zfish   213 -------------AHDASEDVRTLQELYRVWRPSLELR--DNH 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TREX1	NP_338599.1	DnaQ_like_exo	14..211	CDD:447876	54/223 (24%)
		Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0	236..314
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..278
		Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357	243..314
		Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0	281..314
plex9.1	XP_005174272.1	DEDDh	58..228	CDD:176648	53/219 (24%)