Protein Alignment TREX1 and trex2

DIOPT Version :10

• Sequence 1: NP_338599.1
• Gene: TREX1 / 11277
• HGNCID: 12269
• Length: 314
• Species: Homo sapiens
• Sequence 2: XP_004916766.1
• Gene: trex2 / 100488944
• XenbaseID: XB-GENE-921554
• Length: 230
• Species: Xenopus tropicalis
• Alignment Length: 228
• Identity: 99/228 - (43%)
• Similarity: 136/228 - (59%)
• Gaps: 7/228 - (3%)

Human    10 PMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPG 74
            |:::.:|.|:|||||.::.||:|||||:|||..:||:|.|.|.....    |||:|||.|||.|.
 Frog     4 PVKSFVFLDLEATGLNYNLPKITELCLVAVHVSSLENPETDQSEVQL----PRVLDKLCLCVDPK 64

Human    75 KACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELA 139
            |..:..|..|||||...||...:.||:.||..|:..||.||.||.|||||||..||||||:||..
 Frog    65 KPITKEACNITGLSNEKLANCEKPCFNLNLVQLVKEFLNRQAQPVCLVAHNGLFYDFPLLKAEFQ 129

Human   140 MLGLTSALDGA-FCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLA 203
            .  ....|.|: .|:||:.|.:.|.:.....:...:.|::|..:|.|.:|:.|.|||.||||||.
 Frog   130 Q--QNEELPGSLLCLDSLKAFRQLSQQDRRHQEFTKGSHTLTELYRRSFGKEPIDSHYAEGDVLT 192

Human   204 LLSICQWRPQALLRWVDAHARPFGTIRPMYGVT 236
            |:.:..::...||...::..:.:..|.||||.|
 Frog   193 LIKVFMYKASELLEMANSLYKRWSEINPMYGKT 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TREX1	NP_338599.1	DnaQ_like_exo	14..211	CDD:447876	90/197 (46%)
		Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0	236..314		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..278
		Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357	243..314
		Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0	281..314
trex2	XP_004916766.1	TREX1_2	8..200	CDD:99839	90/197 (46%)