DRSC/TRiP Functional Genomics Resources

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Protein Alignment TREX1 and Trex1

DIOPT Version :10

Sequence 1:NP_338599.1 Gene:TREX1 / 11277 HGNCID:12269 Length:314 Species:Homo sapiens
Sequence 2:NP_001020160.1 Gene:Trex1 / 100049583 RGDID:1311998 Length:316 Species:Rattus norvegicus


Alignment Length:317 Identity:235/317 - (74%)
Similarity:259/317 - (81%) Gaps:4/317 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVD 65
            |||||||.|.||||||.|:||||||:||||:||||||||||.|||:...|:|.||.||.||||||
  Rat     1 MGSQALPHGHMQTLIFLDLEATGLPYSQPKITELCLLAVHRHALENSSMSEGQPPPVPKPPRVVD 65

Human    66 KLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYD 130
            |||||:||||.||..|||||||:||.|.|||||.|:||||.||..||:|||||.|||||||||||
  Rat    66 KLSLCIAPGKPCSSGASEITGLTTAGLEAHGRQRFNDNLATLLQVFLQRQPQPCCLVAHNGDRYD 130

Human   131 FPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSH 195
            |||||||||.|.:.|.|||.||||||.|||.||:|||||||||||||||||||||||||:|.|||
  Rat   131 FPLLQAELASLSVISPLDGTFCVDSIAALKTLEQASSPSEHGPRKSYSLGSIYTRLYGQAPTDSH 195

Human   196 TAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASART-KPRPSAVTTTAHLATTRN 259
            |||||||||||||||:|||||:|||.|||||.||:||||:.|:..| .||..|.||::.|||. |
  Rat   196 TAEGDVLALLSICQWKPQALLQWVDKHARPFSTIKPMYGMAATTGTASPRLCAATTSSPLATA-N 259

Human   260 TSPSLGESRGTKDL--PPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE 314
            .|||.|.|||.:..  ||...|.|.||||||||||||..||||:|.|||:.||:||:
  Rat   260 LSPSNGRSRGKRPTSPPPENVPEAPSREGLLAPLGLLTFLTLAIAVLYGIFLASPGQ 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TREX1NP_338599.1 DnaQ_like_exo 14..211 CDD:447876 158/196 (81%)
Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0 236..314 45/80 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..278 19/40 (48%)
Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357 243..314 43/72 (60%)
Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0 281..314 24/32 (75%)
Trex1NP_001020160.1 TREX1_2 14..211 CDD:99839 158/196 (81%)

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