Protein Alignment TREX1 and plex9.2

DIOPT Version :10

• Sequence 1: NP_338599.1
• Gene: TREX1 / 11277
• HGNCID: 12269
• Length: 314
• Species: Homo sapiens
• Sequence 2: NP_001373584.1
• Gene: plex9.2 / 100005742
• ZFINID: ZDB-GENE-110411-9
• Length: 235
• Species: Danio rerio
• Alignment Length: 224
• Identity: 62/224 - (27%)
• Similarity: 86/224 - (38%)
• Gaps: 48/224 - (21%)

Human     7 PPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCV 71
            ||     .:|||:|.|||..|    .|:..||.         .|.|            ...:|.:
Zfish    10 PP-----TVFFDLETTGLDSS----CEIVQLAA---------VSGG------------HTFNLFM 44

Human    72 APGKACSPAASEITGLST--AVLAAHGRQCFDDNLANLLL---AFLRRQPQPWCLVAHNGDRYDF 131
            .|.:.....||.|||.|.  ..|..|.|.....:|...||   :|||....| .|:.||..|:|.
Zfish    45 VPRRPFQRGASRITGFSVKHQRLFLHRRPLLTSSLKEALLSFISFLRMLDHP-LLLGHNIRRFDC 108

Human   132 PLLQAELAMLGLTSALD---GAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPD 193
            |:|...|....|.|...   ..| ||::...:.|.:     :|| .:|:...|:...|.|.|..
Zfish   109 PVLARALDEFSLRSHFQREVSGF-VDTLPLARQLLK-----DHG-LQSFKQESLVKNLLGVSYA- 165

Human   194 SHTAEGDVLALLSICQWRPQALLRWVDAH 222
            :|.|..||.||..: .|:.:.....:..|
Zfish   166 AHNALEDVQALQKL-YWKLKPSANQIQQH 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TREX1	NP_338599.1	DnaQ_like_exo	14..211	CDD:447876	58/204 (28%)
		Necessary for endoplasmic reticulum localization. /evidence=ECO:0000250|UniProtKB:Q91XB0	236..314
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..278
		Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:23979357	243..314
		Necessary for cytoplasmic retention. /evidence=ECO:0000250|UniProtKB:Q91XB0	281..314
plex9.2	NP_001373584.1	DEDDh	13..181	CDD:176648	58/202 (29%)