DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KLHL2 and dbo

DIOPT Version :9

Sequence 1:XP_011529874.1 Gene:KLHL2 / 11275 HGNCID:6353 Length:633 Species:Homo sapiens
Sequence 2:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster


Alignment Length:574 Identity:260/574 - (45%)
Similarity:359/574 - (62%) Gaps:18/574 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    70 QPPTPGFKRLSHLS--LPSSWDYSQNL------LCDVTIVAEDMEISAHRVVLAACSPYFHAMFT 126
            :||:|.  ||||.|  .|.......|:      ||||.:.....:|.||||:|:|||.||.||||
  Fly    40 RPPSPA--RLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFT 102

Human   127 GEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLES 191
            ||:.|||...|.|:::|...:.:|||:.|||.|.|.|.|||.|||||.||||.:::..|||||:.
  Fly   103 GELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKR 167

Human   192 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSE 256
            ||.|.||||||||||.|:|.:||..|:.:.:.:|.:|:.|||||.|.:.|:..:|.||:|.:.||
  Fly   168 QLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSE 232

Human   257 EKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKY 321
            |:||.||::|:.::...|::.:|::::|||||||..::||..|..:.||::..||:|.:.||..|
  Fly   233 EQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNY 297

Human   322 HLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-APKAIRSVECYDFKEERWHQVAELPSRRCR 385
            .||| ::|.||:..|||.|.|....:::..|||. :..||.|||.:|.:...|..||.:..|||.
  Fly   298 LLLP-QERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCG 361

Human   386 AGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWT-SVANMRDRRSTLGAAVLNGLLYAVGGFD 449
            .|:..:..|::||||.:|...:.:::.|||..:||: .||.....|:::|.|||:|.||||||.|
  Fly   362 VGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQD 426

Human   450 GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQC-LSTVECYNATT 513
            |...|:.||.|:.|.|:|..||||.|||..|.|.|:||.|||:||.||   || |:|||.|:...
  Fly   427 GVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDG---QCPLNTVERYDPRH 488

Human   514 NEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGV 578
            |:|..::.|||||...|..|.||.:|||||.|..:...|.|.|:|.||.|..:..|...|...|:
  Fly   489 NKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGL 553

Human   579 CAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKP 632
            ..|||.||.|||.|||..|.::|.|:|.|::|. :..||:..|...||.|:..|
  Fly   554 AVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWR-LCGCMNYRRLGGGVGVMRAP 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL2XP_011529874.1 GVQW 57..>90 CDD:290611 9/21 (43%)
PHA03098 89..613 CDD:222983 244/532 (46%)
BTB 90..189 CDD:279045 52/104 (50%)
BACK 198..300 CDD:285009 46/101 (46%)
Kelch 351..393 CDD:128874 16/42 (38%)
KELCH repeat 383..426 CDD:276965 16/43 (37%)
Kelch 394..440 CDD:128874 18/46 (39%)
Kelch_1 429..474 CDD:279660 24/44 (55%)
KELCH repeat 430..474 CDD:276965 24/43 (56%)
Kelch 488..536 CDD:128874 23/48 (48%)
KELCH repeat 526..570 CDD:276965 18/43 (42%)
Kelch 537..583 CDD:128874 17/45 (38%)
KELCH repeat 573..619 CDD:276965 21/45 (47%)
Kelch 584..631 CDD:128874 20/46 (43%)
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 62/126 (49%)
PHA03098 69..587 CDD:222983 243/522 (47%)
KELCH repeat 359..403 CDD:276965 16/43 (37%)
KELCH repeat 407..451 CDD:276965 24/43 (56%)
KELCH repeat 454..497 CDD:276965 22/45 (49%)
KELCH repeat 501..545 CDD:276965 18/43 (42%)
KELCH repeat 548..593 CDD:276965 21/45 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59391
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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