DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL2 and CG15097

DIOPT Version :9

Sequence 1:	XP_011529874.1	Gene:	KLHL2 / 11275	HGNCID:	6353	Length:	633	Species:	Homo sapiens
Sequence 2:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	253/613 - (41%)
Similarity:	367/613 - (59%)	Gaps:	26/613 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    31 PVTVNPWHMKKAFKVMNELRRQSHSATQAGMQWRDLSSLQPPTPGFKRL--SHLSLP-------S 86
            ||..|  |..:|.....::...|:::||..      |.|.||.|..:.|  :|...|       :
  Fly     4 PVKSN--HSGEASGNNEDVTTTSNNSTQTP------SDLSPPGPNEEVLPQAHHQNPGHCIASFA 60

Human    87 SWDYSQN--LLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRM 149
            :.:..:|  .||||.:......|:|||||||:.||||:|||..:|.|.....||:.:||...||.
  Fly    61 AINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQ 125

Human   150 LIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLL 214
            ||||.||.||.:||:||||||||:||||:..|:..||:||..||||.||||||:|||.|:|.:|.
  Fly   126 LIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELH 190

Human   215 NKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMA 279
            .:::.||.|:|..||.:||||.|..|:|..|||:.:|.|||||:||.|||.||.||...|:..:|
  Fly   191 TRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIA 255

Human   280 RLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMN 344
            .||.:|||||:.|::|:..||.|.|:::.|.||:.|:||||||||| |||.:|.|.||:.|.|..
  Fly   256 ELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLP-EQRSIMGSQRTQERRPEG 319

Human   345 LPKLMVVVGGQAPKAIRSVEC--YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRV 407
            :...:..|||.:..||.: ||  |:.:...|..||.:..||.|:|:..:...::.|||::|...:
  Fly   320 MKPYVFAVGGGSLFAIHN-ECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDL 383

Human   408 RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAP 472
            .|.:||:|:.::|:::..|..:||.||....:.|:|..||:||::.|||:|.|:..:..|.....
  Fly   384 ATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPA 448

Human   473 MNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNL 537
            |:|||....:.|:...:|::||:|..:.|  |:||.::.....|..:..||.|||..||...:..
  Fly   449 MSTRRRYCRLAVLENCIYSLGGFDSTNYQ--SSVERFDPRVGRWQPVPSMSARRSSCGVASTDGH 511

Human   538 LYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY 602
            ||.:||:||.:...|.|.:....|:|..:|.|:..|....|..|.|.|:.:||:|||.:|.|||.
  Fly   512 LYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVER 576

Human   603 YNPTTDKWTVVSSCMSTGRSYAGVTVID 630
            |:...:||:||:: |...||..|..|::
  Fly   577 YDTRLNKWSVVNA-MVARRSSVGAAVLE 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL2	XP_011529874.1	GVQW	57..>90	CDD:290611	10/41 (24%)
		PHA03098	89..613	CDD:222983	230/527 (44%)
		BTB	90..189	CDD:279045	53/100 (53%)
		BACK	198..300	CDD:285009	53/101 (52%)
		Kelch	351..393	CDD:128874	15/43 (35%)
		KELCH repeat	383..426	CDD:276965	12/42 (29%)
		Kelch	394..440	CDD:128874	14/45 (31%)
		Kelch_1	429..474	CDD:279660	16/44 (36%)
		KELCH repeat	430..474	CDD:276965	16/43 (37%)
		Kelch	488..536	CDD:128874	16/47 (34%)
		KELCH repeat	526..570	CDD:276965	15/43 (35%)
		Kelch	537..583	CDD:128874	15/45 (33%)
		KELCH repeat	573..619	CDD:276965	20/45 (44%)
		Kelch	584..631	CDD:128874	20/47 (43%)
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	54/102 (53%)
		PHA03098	65..539	CDD:222983	211/477 (44%)
		BACK	174..276	CDD:285009	53/101 (52%)
		Kelch	324..369	CDD:128874	15/45 (33%)
		KELCH repeat	359..402	CDD:276965	12/42 (29%)
		Kelch	370..415	CDD:128874	14/44 (32%)
		KELCH repeat	406..450	CDD:276965	16/43 (37%)
		Kelch	417..463	CDD:128874	17/45 (38%)
		KELCH repeat	453..496	CDD:276965	11/44 (25%)
		Kelch	464..510	CDD:128874	16/47 (34%)
		Kelch_1	499..543	CDD:279660	16/43 (37%)
		KELCH repeat	500..545	CDD:276965	16/44 (36%)
		KELCH repeat	547..590	CDD:276965	19/43 (44%)
		Kelch	559..603	CDD:128874	20/44 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820