DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP18 and Usp47

DIOPT Version :9

Sequence 1:	NP_059110.2	Gene:	USP18 / 11274	HGNCID:	12616	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	109/409 - (26%)
Similarity:	175/409 - (42%)	Gaps:	74/409 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    34 SNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRS 98
            |:...|...|..:|...|.|.|||.|...||.||||:|...|..:|...|.|.....  |.:.::
  Fly   375 SSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFDN--DNEAKN 437

Human    99 VPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVER 163
            :|:|:..|...:|.|.:.||...:|.......:...:.|||..:|...:::.::.:..:......
  Fly   438 IPYQLQKLFLNLQTSPKAAVETTDLTRSFGWDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANL 502

Human   164 LQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDV-DSKPLKTLEDALHCFFQPRELSSKSK 227
            :..||..::.|.:.|::|..|.:|..:.|.:||.:... .|....::|:||..|.||..|...::
  Fly   503 ISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQ 567

Human   228 CFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTR---KICHSLYFPQSLDF-------- 281
            ..||.|.||....:.|.....|..||:||.||.. :.||.   |:...:.|||:|:.
  Fly   568 YLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDF-DYQTMHRIKLNDRVTFPQTLNLNTFINRSG 631

Human   282 ------SQI--------------------------------------------LPMKRESCDAEE 296
                  ||:                                            :.|...:..:.:
  Fly   632 NSGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAK 696

Human   297 QSGGQ--YELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPN---- 355
            |..|.  |||||::.|.|.|..|||..||::..:.:||||||.|:..::.||||.::|.||
  Fly   697 QGSGPYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFNDQNVTSITQEDIQRSFGGPNGSYY 761

Human   356 ---YHWQETAYLLVYMKME 371
               |.....||:|:|.:::
  Fly   762 SSAYTSSTNAYMLMYRQVD 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP18	NP_059110.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..45		3/10 (30%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269\|PubMed:28165510	36..51		3/14 (21%)
		Mediates interaction with STAT2. /evidence=ECO:0000269\|PubMed:28165510	51..112		21/60 (35%)
		UCH	55..367	CDD:306860	102/382 (27%)
		Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269\|PubMed:28165510	303..312		5/8 (63%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269\|PubMed:28165510	313..372		25/66 (38%)
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	104/388 (27%)
		UCH	395..776	CDD:278850	102/383 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910