DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN2L and PBP1

DIOPT Version :9

Sequence 1:	XP_005255118.1	Gene:	ATXN2L / 11273	HGNCID:	31326	Length:	1104	Species:	Homo sapiens
Sequence 2:	NP_011694.3	Gene:	PBP1 / 853089	SGDID:	S000003410	Length:	722	Species:	Saccharomyces cerevisiae

Alignment Length:	885	Identity:	181/885 - (20%)
Similarity:	290/885 - (32%)	Gaps:	307/885 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    97 GSARGQSTGKGPPQSPVFEGVYNNSRML---------------HFLTAVVGSTCDVKVKNGTTYE 146
            |::....|..|.|..       |||.|.               :.|...:||...|.|.:|..|.
Yeast    18 GNSDSNYTNGGVPNQ-------NNSSMFYENPEITRNFDDRQDYLLANSIGSDVTVTVTSGVKYT 75

Human   147 GIFKTLSSKFELAVDAVHR--KASEPAGGPRREDIV----DTMVFKPSDVMLVHFRNVDFNYATK 205
            |:..:.:.:....:|.|.|  :.::.......:|:.    :|::....||..:..:|:|.:...|
Yeast    76 GLLVSCNLESTNGIDVVLRFPRVADSGVSDSVDDLAKTLGETLLIHGEDVAELELKNIDLSLDEK 140

Human   206 ---DKFTDSAIAMNS----KVNGEH-------------------KEKVLQRWEGGDSNSDDYDLE 244
               .|..::..|..:    :||||.                   ||:.|::|. .:..::.:|:.
Yeast   141 WENSKAQETTPARTNIEKERVNGESNEVTKFRTDVDISGSGREIKERKLEKWT-PEEGAEHFDIN 204

Human   245 -----SDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIE 304
                 .|.|..||   .|..||:.:|||:|:|..|  ||..:.||: ..:.:|...|.::|:|||
Yeast   205 KGKALEDDSASWD---QFAVNEKKFGVKSTFDEHL--YTTKINKDD-PNYSKRLQEAERIAKEIE 263

Human   305 S-SPQYRLRIAME-----NDDGRTEEEKHSAVQRQGSGRESPSLASREGKYIPLPQRVREGPRGG 363
            | .....:.||.:     :|.|..||:.:|.|.|:|    ...||:.:....|
Yeast   264 SQGTSGNIHIAEDRGIIIDDSGLDEEDLYSGVDRRG----DELLAALKSNSKP------------ 312

Human   364 VRCSSSRGGRPGLSSLPP---RGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSP 425
               :|::|.|    .:||   :.|||:|                |:.:|             ||.
Yeast   313 ---NSNKGNR----YVPPTLRQQPHHMD----------------PAIIS-------------SSN 341

Human   426 SNR----PSGETSVPPPPAAPPFLPVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPV 486
            ||:    .|.:||.|....||...|     |.::.|:.
Yeast   342 SNKNENAVSTDTSTPAAAGAPEGKP-----PQKTSKNK--------------------------- 374

Human   487 TSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEPQELARIAGKVPGLQNEQKRFQLEEL 551
                                      |.||:||.                          |:|||
Yeast   375 --------------------------KSLSSKEA--------------------------QIEEL 387

Human   552 RKFGAQFK------------LQPSSSPENSLDPFPPRILKEEPKGKEKEVD-----GLLTSEPMG 599
            :||..:||            |:.|||...|....||:.:.:.|..|.....     |...|...|
Yeast   388 KKFSEKFKVPYDIPKDMLEVLKRSSSTLKSNSSLPPKPISKTPSAKTVSPTTQISAGKSESRRSG 452

Human   600 SPVS---SKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQT--GSPPVGLIKGEDKDEGPVAEQ 659
            |.:|   |.|...:...........|...|.:.|......:.  |......||.::..:    |:
Yeast   453 SNISQGQSSTGHTTRSSTSLRRRNHGSFFGAKNPHTNDAKRVLFGKSFNMFIKSKEAHD----EK 513

Human   660 VKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYIPQIH 724
            .|....:.|.:.|...||..:.....:|                        ....|.::.|.
Yeast   514 KKGDDASENMEPFFIEKPYFTAPTWLNT------------------------IEESYKTFFPD-- 552

Human   725 MGPAVQA-----PQMYPYPVSNSVPGQ---QGKYRGAKGSLPPQRSDQHQPASAP-PMMQAAAAA 780
            ...|:|.     .|.....:.|:|||.   .|...|.....|     ...|:::| |||...||.
Yeast   553 EDTAIQEAQTRFQQRQLNSMGNAVPGMNPAMGMNMGGMMGFP-----MGGPSASPNPMMNGFAAG 612

Human   781 GPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGS---HPQAIVS 842
            .        ...|:|:.|          |||.::||.|...|::.||......|:   |..|...
Yeast   613 S--------MGMYMPFQP----------QPMFYHPSMPQMMPVMGSNGAEEGGGNISPHVPAGFM 659

Human   843 SSTPQYPSAEQPTP-----QALYATVHQSYPHHATQLHAH 877
            ::.|..|......|     |.:..:.....|.:.:.:|:|
Yeast   660 AAGPGAPMGAFGYPGGIPFQGMMGSGPSGMPANGSAMHSH 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_005255118.1	SM-ATX	122..191	CDD:291131	15/89 (17%)
		PBP1	209..750	CDD:227507	123/611 (20%)
		LsmAD	264..326	CDD:284215	23/67 (34%)
		TFIIA	763..>948	CDD:281188	29/124 (23%)
		TFIIA	882..>1074	CDD:281188
PBP1	NP_011694.3	PBP1	3..722	CDD:227507	181/885 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159047266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5180
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		otm52751
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870