Protein Alignment ATXN2L and Atx2

DIOPT Version :9

• Sequence 1: XP_005255118.1
• Gene: ATXN2L / 11273
• HGNCID: 31326
• Length: 1104
• Species: Homo sapiens
• Sequence 2: NP_732033.1
• Gene: Atx2 / 41883
• FlyBaseID: FBgn0041188
• Length: 1084
• Species: Drosophila melanogaster
• Alignment Length: 1185
• Identity: 291/1185 - (24%)
• Similarity: 431/1185 - (36%)
• Gaps: 403/1185 - (34%)

Human    90 RPGAAAIGSARGQSTGKGPPQSPVFEGVYNNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSS 154
            ||.....|:..|..   |....|..:|||||:..:|..||:|||..:|::::|..|||:|:|.|.
  Fly    31 RPTNNKAGAGGGNG---GAAVRPSAQGVYNNTFFMHSATALVGSVVEVRLRSGNIYEGVFRTFSG 92

Human   155 KFELAVD--AVHRKASEPAGG--PRREDIVDTMVFKPSDVMLVHFRNVDFNYATKDKF-TDSAIA 214
            .|::|::  |..:..:.|..|  |:.      ::|....|:.:..::.|..|||...| ||.||
  Fly    93 NFDIALELPACIKSKNLPEEGKVPKH------IIFPADTVVTIVAKDFDSQYATAGAFQTDGAI- 150

Human   215 MNSKVNGEH-KEKVLQRWEGGDSNSDDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYT 278
             :.|.||.. .||.|:.|:.|.:...|.:|:| .:|||||||||:.||..:||.:|:|.||:|||
  Fly   151 -SDKCNGARPDEKELEPWDSGANGDIDIELDS-AANGWDPNEMFRKNENTFGVTSTFDDSLASYT 213

Human   279 VPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAMENDDGRTEEEKHSAVQR----------- 332
            |||:|.:|.||::.|.:|.:||.|||::|..|.|:.:||.|   ||...:||:|
  Fly   214 VPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENGD---EEALFAAVERPSTEQDQRGDR 275

Human   333 ---------------------------QGSG----RESPSLASREGKYIPLPQRVREGP------ 360
                                       :|:|    ||:.|    ..:||....|...||
  Fly   276 GDRERNDRDREREERDRDRDRDRGNKPRGAGDFQLRETMS----SDRYITKQTRSITGPQLSHVG 336

Human   361 ---------------------------RGGVRCSSS----RGGRPGLSSLP-------------- 380
                                       :||...|::    .||..|:...|
  Fly   337 MSSQGSGRDRDTRGDGSMMMQSGGGSGQGGSTQSTAALMLAGGLKGVGPAPSANASADSSSKYSG 401

Human   381 ---------PRGPHHLDNSSPGPGSE---ARGINGG----------PSRMSP------------- 410
                     |:|...:.|:.|..||.   ::|.||.          ||...|
  Fly   402 GSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGNGNSVGQNKGGYQPSMGMPSQYSYQGNSQIMH 466

Human   411 -----KAQRPLRGAKTLSSPSNRPSGETSVPPPPAAPPFLPVGRMYPPRSPKSAAPAPISASCPE 470
                 :.|..:.||..|:..||   ..|:.|        ||..:|...:..:|.:......   |
  Fly   467 GSSQYRNQSHMGGANKLNGDSN---ANTNKP--------LPQRQMRQYQGSQSNSSLNYGG---E 517

Human   471 P-PIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEPQELARIAG 534
            | .:|..|..|....|..:|.|.|    :..|.|:    ....::...::..:..:|.:..:...
  Fly   518 PQSLGKPVHGSHGGHPGQNSNSPP----LQTAGPQ----QQQQQQQQQQQQQQQQQPPQQQQHQN 574

Human   535 KVPGLQNEQ-------KRFQLEELRKFGAQFKLQPS--SSPEN---------------------S 569
            ..|..||.|       :..|::|||:||..|:|.||  |.|:.                     .
  Fly   575 IQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQQQQQQQQQQQHQVQQQQQRALQ 639

Human   570 LDPFPPRILKEEPKGKEKEV----------DGLLT-------SEPMGSP---------------- 601
            ....||:..:::.:.::..|          ...|:       .:|..:|
  Fly   640 QSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQQPQQAPLPQQQHVPHHMQQKAQ 704

Human   602 ----VSSKTESVSDKEDKPPLA---PSGGTEGPEQPPPPC-----PSQTGSP-----PVGLIKGE 649
                |.::.:.|..:....|..   |....:.|.|.|.|.     |.|| ||     || |::..
  Fly   705 QQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHTMPPPQT-SPVVVTSPV-LLEQP 767

Human   650 DKDEGPVAEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSP 714
            .....||.:|.:...|.....|.:|..|    :.:|:|||.    ..|||:..|:.:..|...:|
  Fly   768 PPQPMPVVQQQQTQQLATPKPEVSPAPP----SSNTTTPTG----IASTPTAGVIASAGSEKTTP 824

Human   715 QYISYIPQIHMGPAVQAPQMYPYPVSNS--VP-GQQGKYRGAKGSLP------------------ 758
                               ..|.|.|||  || |......||.|:.|
  Fly   825 -------------------AAPTPTSNSATVPTGTAATAGGATGTTPVVKKHVLNPSAKPFTPRG 870

Human   759 ---PQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYI-----PYNPQQFP--GQPAMMQPMAH 813
               |..|..|.|.:..||.......|..:..|.....|:     |:.||..|  |||..:: .::
  Fly   871 PSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPAANQPIYVMQPQHPFPPQTHPQAGQPPRLR-RSN 934

Human   814 YPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQ------ALYATVHQSYPHHAT 872
            ||      ||..|...:..|.:..|.::::.         |.||      |.:....||:.:...
  Fly   935 YP------PMAASQMHVSASAATGQPLITAG---------PIPQFIQYGHAPHQQQFQSHTYAPM 984

Human   873 QLHAHQPQPATTPTGSQ-PQSQHAAPSPVQQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPG 936
            |:..:..||......:| |||  ..|||              |||.|. :||      ||.  |.
  Fly   985 QMRVYPDQPQQLQFMTQTPQS--TTPSP--------------GQPHQQ-FHP------PPQ--PS 1024

Human   937 PSAQSPQSSF--PQPAAVY---AIHHQQL--PHGFTNMAHVTQAHVQTGITAAPPPHPGAPHPPQ 994
            |:...||.:|  |..||.|   .:|.|.|  .|.|                  |||.|  .||.|
  Fly  1025 PAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYF------------------PPPTP--QHPQQ 1069

Human   995 -------VMLLHPPQ 1002
                   ||..|.||
  Fly  1070 NQQQYQIVMQQHQPQ 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_005255118.1	SM-ATX	122..191	CDD:291131	21/72 (29%)
		PBP1	209..750	CDD:227507	176/758 (23%)
		LsmAD	264..326	CDD:284215	31/61 (51%)
		TFIIA	763..>948	CDD:281188	50/200 (25%)
		TFIIA	882..>1074	CDD:281188	41/136 (30%)
Atx2	NP_732033.1	SM-ATX	61..128	CDD:291131	22/72 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159132
Domainoid	1	1.000	67	1.000	Domainoid score	I9826
eggNOG	1	0.900	-	-		E1_COG5180
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3623
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49273
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		otm41597
orthoMCL	1	0.900	-	-		OOG6_108744
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.880