DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN2L and atxn2l

DIOPT Version :9

Sequence 1:	XP_005255118.1	Gene:	ATXN2L / 11273	HGNCID:	31326	Length:	1104	Species:	Homo sapiens
Sequence 2:	XP_005163856.1	Gene:	atxn2l / 324525	ZFINID:	ZDB-GENE-030131-3246	Length:	1004	Species:	Danio rerio

Alignment Length:	1118	Identity:	474/1118 - (42%)
Similarity:	602/1118 - (53%)	Gaps:	253/1118 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    49 PGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQERPGAAAIGSARGQSTGKGPPQS-P 112
            |||             .|.....|..|.:|...|....::..||       |.:::.|.|.|| |
Zfish     9 PGP-------------GGRKTSNGTSGSMASSVPGSNSNRPNPG-------RNRNSVKTPSQSPP 53

Human   113 VFEGVYNNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGG---- 173
            |||||||||||||||||||||.|||.||||:.||||||||||:.||||||||:..:|...|
Zfish    54 VFEGVYNNSRMLHFLTAVVGSRCDVMVKNGSLYEGIFKTLSSRCELAVDAVHKVKNEEGDGGGGG 118

Human   174 -----PRREDIVDTMVFKPSDVMLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEG 233
                 ||:|:|.|||:|.|||::.:..|:||.||||:|.||||||. :|::||:|:|||||||:|
Zfish   119 GTAVHPRKEEITDTMIFGPSDLVTMICRDVDLNYATRDTFTDSAIG-SSRLNGDHREKVLQRWDG 182

Human   234 GDSNSDDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQ 298
            ||||.:::||::|.:||||.:|||:||||.||||:|||||||.||||||:.:||.|||||.|||:
Zfish   183 GDSNGENFDLDADTANGWDASEMFRFNEETYGVKSTYDSSLSMYTVPLERGSSEGFRQREARAAR 247

Human   299 LAREIESSPQYRLRIAMENDDGRTEEEKHSAVQR--------QGSGRESP---SLASREGKYIPL 352
            ||.|||:|.|||.|:|:|||:|||:|:|.|||.|        :..||:||   |..||||||||
Zfish   248 LANEIEASSQYRHRVALENDEGRTDEDKFSAVVRDREREAAERERGRDSPGFSSAGSREGKYIP- 311

Human   353 PQRVRE--------GPRGG-VRCSSSRGGRPGLSS-------------LPP---------RG--- 383
            |||.||        |.||| |....:|..|||.||             |||         ||
Zfish   312 PQRAREREMGVSGRGERGGAVSTLPNRTNRPGPSSSSPRPLPSANSQALPPTDRNSSLSVRGGFS 376

Human   384 ------------------------PHHLDNSSPGPGS---EARGINGGPSRMSPKAQRPLRGAKT 421
                                    ||.|.:|...|.|   .||.:||    :|||:||..:..:.
Zfish   377 THQSQSSTPTQSRPSEPGHSSPPSPHTLSHSLSHPQSLSDVARPVNG----VSPKSQRTGQTNRN 437

Human   422 LSSPSNRPSGETSVPPPPAAPPFLPVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPV 486
            :.:.::..|...|                   ||||..||       |:.|:            :
Zfish   438 MRTSNSHSSPTVS-------------------RSPKPDAP-------PQDPL------------L 464

Human   487 TSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRT-LEPQELARIAGKVPGLQNEQKRFQL-E 549
            |.|..||   |..|..| ..|.|.||.|:.:||...: :.|||     ||...:.:.|:|.|: |
Zfish   465 TGSYLDP---SSKPVGP-TPLFPVDVNEILSKERMESPVGPQE-----GKSNKIPSVQQRSQISE 520

Human   550 ELRKFGAQFKLQ--PSSSPENSLD------------------PFPPRI----LKEEPKGKEKEVD 590
            ||||||..|:||  |.:.|..|..                  |.||..    |..|.:.:|...:
Zfish   521 ELRKFGNTFRLQQNPKTLPTESTQANPAHNTQTDPAAPTEAKPAPPTTPNTELSAEERSRETNPE 585

Human   591 GLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGP 655
            |.:||.|  .|.:|.:.........||  ..|.|.|..||.....|:.|.|     :..::.||
Zfish   586 GPVTSTP--PPATSISAPSGIGMQNPP--AEGQTAGAPQPARTPGSEDGKP-----EAPERSEG- 640

Human   656 VAEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLT-AGQSGLYSPQYISY 719
            :.:||||||||||||||||||..||:.|.::|||.|.| |..:|::.:.| .||..:|:|||:||
Zfish   641 MTDQVKKSTLNPNAKEFNPTKAPLSMVKPSATPTPPRP-TPPSPTVVLQTQPGQGAVYNPQYLSY 704

Human   720 IPQIHM---GPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAG 781
            :.|:.:   |.:|| ||: ||....:|  .||||...|||:...|.|  ..:|||||:|||:|||
Zfish   705 VSQVPIQIQGHSVQ-PQI-PYSYMTAV--SQGKYPRTKGSVVTPRPD--HSSSAPPMIQAASAAG 763

Human   782 PPLVAATPY-SSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSST 845
            |||| |:|| .||:.|| |..|..|       |||...|:: |||..||||.||.||||: ....
Zfish   764 PPLV-ASPYPPSYLQYN-QVIPAMP-------HYPGHQVYS-MLQGGPRMLGSGGHPQAL-GPPG 817

Human   846 PQYP-SAEQPT--PQALYATVHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQQHQAGQ 907
            |||| ..|.|:  .|.:||.  ||:.||:..:|   |||::|||||||..||.||||.|..|:|.
Zfish   818 PQYPGQTEGPSAPQQGMYAP--QSFSHHSGSIH---PQPSSTPTGSQPPPQHPAPSPGQSGQSGP 877

Human   908 APHLGSGQPQQNLYHPGALTG-TPPSLPPGPSAQSPQSSFPQPAAVYAI-HHQQLPHGFTNMAHV 970
            .|        |:|||.|.|:. |||:||||.|  |||:|:....  |:: .||.|||.::::..:
Zfish   878 QP--------QSLYHSGPLSAPTPPNLPPGHS--SPQASYSLQG--YSLPGHQPLPHPYSSLGQL 930

Human   971 TQAHVQTGITAAPPPHPGAPHPPQVMLLH-PPQSHGGPPQGAVPQSG-----------VPALSAS 1023
            |||||...::.  |.|.|...||.||||| .||...||..|..||.|           || :.|.
Zfish   931 TQAHVPGALSG--PHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQGAHQHFTYLGPQVP-VQAH 992

Human  1024 TPSPYPYIGHPQG 1036
            .|...||  ||.|
Zfish   993 NPQQIPY--HPSG 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_005255118.1	SM-ATX	122..191	CDD:291131	50/77 (65%)
		PBP1	209..750	CDD:227507	251/642 (39%)
		LsmAD	264..326	CDD:284215	45/61 (74%)
		TFIIA	763..>948	CDD:281188	95/189 (50%)
		TFIIA	882..>1074	CDD:281188	73/169 (43%)
atxn2l	XP_005163856.1	SM-ATX	63..142	CDD:291131	50/78 (64%)
atxn2l	XP_005163856.1	LsmAD	213..275	CDD:284215	45/61 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194340863
Domainoid	1	1.000	234	1.000	Domainoid score	I10541
eggNOG	1	0.900	-	-		E1_COG5180
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16513
Inparanoid	1	1.050	650	1.000	Inparanoid score	I4769
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49273
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108744
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	1	1.000	-	-		X9068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.290