DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN2L and SPBC21B10.03c

DIOPT Version :9

Sequence 1:	XP_005255118.1	Gene:	ATXN2L / 11273	HGNCID:	31326	Length:	1104	Species:	Homo sapiens
Sequence 2:	NP_595684.1	Gene:	SPBC21B10.03c / 2540677	PomBaseID:	SPBC21B10.03c	Length:	791	Species:	Schizosaccharomyces pombe

Alignment Length:	805	Identity:	179/805 - (22%)
Similarity:	279/805 - (34%)	Gaps:	233/805 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   209 TDSAIAMNSKVNGEHKEKVLQRW--EGGDSNSDDYDLESDMSN-GWDPNEMFKFNEENYGVKTTY 270
            ||.||:...:.  |.:::.|:||  :..|:......||....| .||   .|..||:.:|||:.:
pombe   103 TDVAISAEKRT--ETRQRELRRWMPDPEDAGVPLAGLEESTDNVEWD---QFATNEKLFGVKSHF 162

Human   271 DSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAME-----NDDGRTEEEKHSAV 330
            |..|  ||..:::.: .:::::|..|.::|:|||.:....:.||.|     :|.|..||:.:|.|
pombe   163 DEDL--YTSRIDRSH-PKYKEKEQEADRIAKEIEGTVTNNIHIAEERGLKVDDSGLDEEDLYSGV 224

Human   331 QRQ--------GSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGP--- 384
            .|.        .|...:.:...::.|....|.:                 .|....:||..|
pombe   225 HRSIDVVRNYTRSNAYNKNNKDQKPKNHEAPHQ-----------------HPQQKVVPPDDPAIV 272

Human   385 --HHLD-NSSPGPGSEA--RGIN----GGP-SRMSPKAQ-----RPLRGAKTLSSPSNRPSGETS 434
              .||. ..:|||.|.|  |..|    .|| ||...:.|     :..:..|..|..|.:||...|
pombe   273 SHRHLALPRAPGPDSRAAERFFNARRKAGPLSRREKEGQIKEFMQFSQSLKIGSLDSKQPSSTKS 337

Human   435 VPPPPAAPPFLPVGRMYPPRSPKSAAPAPISASCP-----EPPIGSAVPTSSASI-PVTSSVSDP 493
            |.....|..     :..|..|.::   .|..:..|     |.|:.||...||..: .|..:.|.|
pombe   338 VAEVKVADE-----KQLPDASSQA---TPADSKEPRKEEAEKPVTSATEVSSEKVEKVDGNTSSP 394

Human   494 GVGSISPAS-PKISLAPTDVKELSTKEPGRTLEPQELA---RIAGKV--PGLQNEQKRFQLEELR 552
            ......|:: |:.....|..||.:..:.|..|..:.::   .:|..|  ||
pombe   395 SKEEEKPSTEPEKPSVVTQRKETTGTKLGTKLNAKAISFKPNVAAPVFTPG-------------- 445

Human   553 KFGAQFKLQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEP----------------MGSP 601
                :|.:....:|.|:..|..|    ::....|..:.......|                ...|
pombe   446 ----KFTIPSKPAPVNASRPMMP----QQSNNSEASIPSTTPQSPSVVSNGENKPSSSPVFFNGP 502

Human   602 VSSKTESVSDKEDKPPLAPSGGTE--GPEQPPPP--CPSQTGSPPVGLIK--GEDKDEGPVAEQV 660
            |||:.|.:.|..:   :..:.|.|  |.||...|  ||....:.|..|.:  ...:.||......
pombe   503 VSSEKEPILDNFN---VFKNVGEEHQGAEQIDKPFSCPPTWNTGPNSLQQTIANSRPEGNSGSAK 564

Human   661 KKSTLNPNAKEF---------------NPTKPLLSVN----------KSTSTPTSPGPRTHSTPS 700
            |.:..||.....               .||.|.:.|.          ::.|..||..|..:.||
pombe   565 KAAAANPMIPSIVLPNSAMPSAMPMYPTPTMPYIPVGYPVPGYTPYMRNPSQHTSVAPSPNGTP- 628

Human   701 IPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMY-PYPVSNSVPGQQGKYRGAKGSLPPQRSDQ 764
                |:|.|.......|.|:          |||.. ||.:....|...|  |||..
pombe   629 ----TSGNSSTVGSPMIGYM----------APQFIPPYAMPQFPPSGNG--RGASA--------- 668

Human   765 HQPAS--APPM--MQAAAAAG-PPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPML 824
              ||:  .|.|  |.|....| ||:     |..|.|.|        .||.  .||   |::....
pombe   669 --PATYFVPQMGGMMAYTMNGVPPM-----YGQYAPNN--------GMMN--MHY---PMYGDSR 713

Human   825 QSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAHQPQPATTPTGSQ 889
            :||.:...:.|:.:.                     :.||::  ::|:...:|.       ..|.
pombe   714 RSNSQRSFNSSNGKR---------------------SNVHKN--NNASNTFSHS-------NAST 748

Human   890 PQSQHAAPSPVQQHQAGQAPHLGSG 914
            ..|.:|||:...:..:..||.:..|
pombe   749 SSSLNAAPNTTAKSSSQTAPPVSKG 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_005255118.1	SM-ATX	122..191	CDD:291131
		PBP1	209..750	CDD:227507	143/634 (23%)
		LsmAD	264..326	CDD:284215	20/66 (30%)
		TFIIA	763..>948	CDD:281188	33/157 (21%)
		TFIIA	882..>1074	CDD:281188	8/33 (24%)
SPBC21B10.03c	NP_595684.1	PBP1	1..739	CDD:227507	170/762 (22%)
SPBC21B10.03c	NP_595684.1	LsmAD	156..220	CDD:284215	20/66 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5180
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2195
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.080