Protein Alignment ATXN2L and atx-2

DIOPT Version :9

• Sequence 1: XP_005255118.1
• Gene: ATXN2L / 11273
• HGNCID: 31326
• Length: 1104
• Species: Homo sapiens
• Sequence 2: NP_001367241.1
• Gene: atx-2 / 176465
• WormBaseID: WBGene00000231
• Length: 1070
• Species: Caenorhabditis elegans
• Alignment Length: 1143
• Identity: 261/1143 - (22%)
• Similarity: 375/1143 - (32%)
• Gaps: 372/1143 - (32%)

Human   120 NSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRR--EDIVDT 182
            |..:|..:..::|....:...:...|.|:...:|..|:..:..|.....|......|  .:..|.
 Worm   122 NGDVLSAINDMIGRVIIINTTDKKRYSGVLGAVSQDFDFGMQCVVEITKENENNLLRTESECRDK 186

Human   183 MVFKPSDVMLVHFRNVDFNYATKD--------KF-TDSAIAMNSKVNGEHKEKVLQRWEGGDSNS 238
            |||..||:       |||.|.|::        || ||.....::.:.||.    ||.|.||:.:.
 Worm   187 MVFHYSDI-------VDFAYVTQEIKKQHAVSKFVTDRQYHGDTPIEGEE----LQEWNGGEEDG 240

Human   239 DDYDLESDM-----------SN------GWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNS 286
            ....:|.|:           ||      ||..|:||..||: ..|.:|:...|:.||. :|...:
 Worm   241 LGGSIEDDVVVAGGQTAARRSNNHNNGTGWSVNDMFAANEK-MNVVSTFKEDLTQYTT-VEVVGT 303

Human   287 EEFRQRELRAAQLAREIESSPQYRLRIAMENDD----------------GRTEEEKHSAVQRQGS 335
            :|.|   .||.:|||||||:...:....:||||                |...:..:::..:|..
 Worm   304 DEDR---ARAERLAREIESNSSSKFMANLENDDDERDLDKITRQEDFENGNGRKRNNNSFNQQQQ 365

Human   336 GRESPSLASREGKYIPLPQRVREGPRGGVR------CSSSRGGRPGLSSLPPRGPHHLDNSSPGP 394
            .|.:|::|. .|:  |:.:|. ||.||..|      .::||.|.|..:.     .::..|.....
 Worm   366 QRRNPNIAP-NGQ--PVNRRA-EGLRGDRRNSGSSSANNSRYGAPAAAQ-----QNYSQNQQQQQ 421

Human   395 G---------------SEARGINGGPSRMSPKAQ------RPLRGAKTLSSPSNRPSGETSVPPP 438
            |               ::.:|.|.|......:.|      ||....|.....:...:..|:....
 Worm   422 GQKGYRRQNEENDWQMAKGKGQNQGHDHSFRQQQKQMLDPRPNNNVKPADDKAQSATTATAAAGG 486

Human   439 PAAPPFLPVGRMYP-PRSPKSAAPAPISASCPEPPIGSA---VPTSSASIPVTSSVSDPGVGSIS 499
            .........|..:. ..:||..|||     .|....|||   .|.||.....:|:.|.|
 Worm   487 SRVTDLKNWGNEFSIATAPKDQAPA-----VPAGNSGSAWNRGPPSSLVAKGSSNESTP------ 540

Human   500 PASPKISLAPTDVKELSTKEPGRTLEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQFKLQPSS 564
            |.:       |:.:|..||:........::|  |..|..:||:.::.|.::          ..|.
 Worm   541 PPT-------TNGEEAETKKEEAPSTSVDVA--AAPVQNVQNDAEKHQEDD----------NVSV 586

Human   565 SPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTE---- 625
            :.||                     |.::||:.     ||...:::..|.||.:||:..|.
 Worm   587 TSEN---------------------DSVITSKS-----SSFKFNINAPEFKPRVAPATPTATTPV 625

Human   626 ----GPEQPPPPC--PSQTGSPPVGLIKGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPLLSVNKS 684
                .|:|.|.|.  ..|.|.|..|:        |.|
 Worm   626 QNEYHPQQQPHPAMMAPQQGPPAPGM--------GMV---------------------------- 654

Human   685 TSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQ-G 748
              .|...||:....|  |::...|:|........| ||.|..|....|.       ..||||. |
 Worm   655 --PPHMGGPQNQGQP--PMMMWQQTGQQQQGGGGY-PQNHQFPIQHVPM-------QGVPGQMYG 707

Human   749 KYRGAKGSLPPQRSDQHQ-PASAPPMMQAAAAAG-----PPLVAATPYSSYIPYNPQQFPGQPAM 807
            .......::..|.:.||| |.||..........|     .||        |:||.|.|.  .|..
 Worm   708 PGAATPVTVAQQPNQQHQVPTSAAGGQNHQLRDGEYREKQPL--------YMPYGPPQM--VPVT 762

Human   808 MQPMAH--YPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHH 870
            .|...|  |..|     |.|:.|.                 |.....|..||..|...:|
 Worm   763 SQQFYHSQYQGQ-----MQQAAPY-----------------QMKMMPQQAPQGAYQQRYQ----- 800

Human   871 ATQLHAHQPQP-ATTPTGSQPQSQHAAPSPVQQHQAGQAPHLGSGQPQQNLY---------HPGA 925
                   |||. ...|.|.|.|.::..|.|.||.|        ..||||..:         ||.:
 Worm   801 -------QPQVYMMPPQGQQQQPRYQGPPPPQQQQ--------QQQPQQQQFSGEQSRPQSHPNS 850

Human   926 LTGTPPSLPPGPSAQSPQ-SSFPQPAAVYAIHHQQLPHGFTNMAHVTQAHVQTGITAAPPPHPGA 989
            ...|     |||..:.|: |..||...:.|       ...:|.:|......|:|..:..|  |||
 Worm   851 QPTT-----PGPRGELPKMSGAPQNGNMQA-------ESSSNASHSGSTSSQSGQRSGSP--PGA 901

Human   990 -PHPPQVMLLHPPQSHGGPPQGAVPQSGVP----------------------ALSASTPS----P 1027
             |.||.....|..|.|  ||..|.|..|.|                      .:....|:    |
 Worm   902 VPPPPPPQQQHQQQQH--PPHHAPPHVGAPPPQMMQQQQQHIQQYMVMQGPHQMHPQIPNYYQQP 964

Human  1028 ----YPYI----------GHPQ----GEQPGQAPGFP--GGADDRILCRVGRSHSRRR------- 1065
                ||.|          .|||    ||:..|  |||  |..|.|.:....:...:::
 Worm   965 QALFYPMIMPQQMPMQQNQHPQQSLMGERSDQ--GFPTSGYFDYRTMPNYQQQQQQQQQQMHRQN 1027

Human  1066 ---------QGLAPGSVLCFPPSSLSCDPAAPLPTASP 1094
                     ||:.|......||     .|..|....:|
 Worm  1028 SLPQQFQGNQGVNPSGQQSGPP-----PPPPPSQQGTP 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_005255118.1	SM-ATX	122..191	CDD:291131	15/70 (21%)
		PBP1	209..750	CDD:227507	137/615 (22%)
		LsmAD	264..326	CDD:284215	22/77 (29%)
		TFIIA	763..>948	CDD:281188	52/203 (26%)
		TFIIA	882..>1074	CDD:281188	64/264 (24%)
atx-2	NP_001367241.1	SM-ATX	126..198	CDD:405176	17/78 (22%)
		LsmAD	283..338	CDD:399606	21/58 (36%)
		Med15	<626..>807	CDD:312941	60/272 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I4034
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49273
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		otm16087
orthoMCL	1	0.900	-	-		OOG6_108744
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.020