Protein Alignment SNX18 and MVP1

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_013717.1
• Gene: MVP1 / 855016
• SGDID: S000004606
• Length: 511
• Species: Saccharomyces cerevisiae
• Alignment Length: 570
• Identity: 122/570 - (21%)
• Similarity: 207/570 - (36%)
• Gaps: 169/570 - (29%)

Human   148 QGSDDDWD---DEW--DDS---STVADEPGALG-SGAYPDLDGSSSAGVGAAGRYRLSTRSDLS- 202
            :|| |.|:   :.|  ||.   ||...||...| ||.:..|:.|:...........|.|...|.
Yeast     5 EGS-DPWNTSSNAWTKDDDHVVSTTNSEPSLNGISGEFNTLNFSTPLDTNEEDTGFLPTNDVLEE 68

Human   203 ---------LGSRGGSVPPQHHPSGPKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKL 258
                     ||:.|.|    ..|:...:...:.:|..|.....:|  ||.:|
Yeast    69 SIWDDSRNPLGATGMS----QTPNIAANETVIDKNDARDQNIEES--EADLL------------- 114

Human   259 CVVLGPYGPEWQEN---PY-PFQCTI----DDPTKQTKFKGMKSYISYKLVPTHTQVP-----VH 310
                     :|..|   .| |....|    :.|.::.......:|:...|:...:..|     |.
Yeast   115 ---------DWTNNVRKTYRPLDADIIIIEEIPEREGLLFKHANYLVKHLIALPSTSPSEERTVV 170

Human   311 RRYKHFDWLYARLAEKFPVISVPHLPEKQ-ATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDV 374
            |||..|.||...|.:::|...:|.||.|: .:...::.|:.|||.||..::|.:..||.|:..|:
Yeast   171 RRYSDFLWLREILLKRYPFRMIPELPPKRIGSQNADQLFLKKRRIGLSRFINLVMKHPKLSNDDL 235

Human   375 FQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMD 439
            ...|||.  .||..:|   :::|..|
Yeast   236 VLTFLTV--RTDLTSW---RKQATYD--------------------------------------- 256

Human   440 DSALQLNHTANEFARKQVTG-----FKKEY-QKVGQSFRGLSQAFELDQQAFSVGL--------N 490
                    |:||||.|:::.     :|||: ::..|:...:..:.||   .:.:.|        .
Yeast   257 --------TSNEFADKKISQEFMKMWKKEFAEQWNQAASCIDTSMEL---WYRITLLLERHEKRI 310

Human   491 QAIAFTGDAYDAIGELFAE-----QPRQDLDPVMDL---LALYQGHLANFPDIIHVQ----KGKA 543
            ..:....:.::.:.:.|:|     .|.|..|.::|:   |::.:.||.....|...:    .|..
Yeast   311 MQMVHERNFFETLVDNFSEVTPKLYPVQQNDTILDINNNLSIIKKHLETTSSICKQETEEISGTL 375

Human   544 WPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGALTKVKESRRHVEEGKMEVQKADGIQDRCNTI 608
            .|..::...:|..|:.         :.|.|...|...|.|.:||||..|.:::...|..|
Yeast   376 SPKFKIFTDILLSLRS---------LFERYKIMAANNVVELQRHVELNKEKLESMKGKPD----- 426

Human   609 SFATLAEIHHFHQIRVRDFKSQMQH-----FLQQQII----FFQKVTQKL 649
              .:.||.....:|..:|.:|.::.     .::|.|:    .||: ||.|
Yeast   427 --VSGAEYDRIKKIIQKDRRSIIEQSNRAWLIRQCILEEFTIFQE-TQFL 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830
		PHA01929	<81..>138	CDD:177328
		PX_SNX18	276..403	CDD:132819	37/136 (27%)
		BAR_SNX18	415..656	CDD:153354	51/270 (19%)
MVP1	NP_013717.1	COG5391	1..511	CDD:227680	122/570 (21%)